Adult Clinical Trials

Brain Cancer

If you need additional information about any of the trials listed or would like to inquire about other open trials, please contact 919.684.5301 or visit The Preston Robert Tisch Brain Tumor Center at Duke.

16 trials identified.

In-Vitro Generation and Characterization of Cytotoxic T Lymphocytes (CTL) Using Dendritic Cells From Malignant Glioma Patients Pulsed with RNA
Phase: Pilot / Feasibility
Sponsor: PI initiated
Principal Investigator: Gerald Archer
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00009403

Primary and Recurrent Glioma Registry (PRoGREss)
Phase: N/A
Sponsor: PI initiated
Principal Investigator: Annick Desjardins
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00027120

PERFORMANCE: Peptide Targets for Glioblastoma Against Novel Cytomegalovirus Antigens
Phase: Phase I
Sponsor: PI initiated
Principal Investigator: David Ashley
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00034208
View this trial at ClinicalTrials.gov

Phase I Single-Center, Dose Escalation Study of D2C7-IT Administered Intratumorally via Convection-Enhanced Delivery for Adult Patients with Recurrent Malignant Glioma
Phase: Phase I
Sponsor: Internal Investigator Initiated Therapeutic &/or Interventional
Principal Investigator: Dina Randazzo
Contact: Preston Robert Tisch Cancer Center
Phone: 919.684.5301
Reference Number: 00053325
View this trial at ClinicalTrials.gov

RESIST: Patients with IDH1 Positive Recurrent Grade II Glioma Enrolled in a Phase I Safety and Immunogenicity Study of Tumor-Specific Peptide Vaccine
Phase: Phase I
Sponsor: Internal Investigator Initiated Therapeutic &/or Interventional
Principal Investigator: Katherine Peters
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00054746
View this trial at ClinicalTrials.gov

A Phase 1/2 Trial for Patients with Newly Diagnosed High Grade Glioma Treated with Concurrent Radiation Therapy, Temozolomide, and BMX-001 (BioMimetix study # BMX-HGG-001)
Phase: Phase I
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Katherine Peters
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00062660
View this trial at ClinicalTrials.gov

Phase 2 Study of Sym004 for Adult Patients with Recurrent Glioblastoma
Phase: Phase II
Sponsor: Internal Investigator Initiated Therapeutic &/or Interventional
Principal Investigator: Annick Desjardins
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00063483
View this trial at ClinicalTrials.gov

ExCeL: EGFRvIII Chimeric Antigen Receptor (CAR) Gene-modified T cells for Patients with Newly-Diagnosed GBM during Lymphopenia
Phase: Phase I
Sponsor: Internal Investigator Initiated Therapeutic &/or Interventional
Principal Investigator: David Ashley
Contact: Preston Robert Tisch Brain Tumor Research Center
Phone: 919.684.5301
Reference Number: 00069444
View this trial at ClinicalTrials.gov

A Randomized Phase 3 Single Blind Study of Temozolomide plus Radiation Therapy combined with Nivolumab or Placebo in Newly Diagnosed Adult Subjects with MGMT-Methylated (tumor 06-methylguanine DNA methyltranferase) Glioblastoma (BMS CA209-548)
Phase: Phase III
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Katherine Peters
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00071737
View this trial at ClinicalTrials.gov

Phase II randomized study to evaluate efficacy, patient satisfaction, and compliance of the oral combination of Rolapitant (Varubi) plus ondansetron vs. ondansetron monotherapy in malignant glioma patients receiving radiotherapy (RT) and concomitant temozolomide
Phase: Phase II
Sponsor: Internal Investigator Initiated Therapeutic &/or Interventional
Principal Investigator: Mary Affronti
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00076418
View this trial at ClinicalTrials.gov

MDNA55-05: An Open-Label Non-Randomized, Multi-Center Phase-2 Study of Convection Enhanced Delivery (CED) of MDNA55 in Adults with Recurent or Progressive Glioblastoma
Phase: Phase II
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Dina Randazzo
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00076523
View this trial at ClinicalTrials.gov

A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy
Phase: Phase III
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Annick Desjardins
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00076758
View this trial at ClinicalTrials.gov

A randomized Phase 2 study of Oncolytic Polio/Rhinovirus Recombinant (PVSRIPO) alone or in combination with lomustine in recurrent WHO grade IV malignant glioma patients
Phase: Phase II
Sponsor: Internal Investigator Initiated Therapeutic &/or Interventional
Principal Investigator: David Ashley
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00077024
View this trial at ClinicalTrials.gov

Laser Interstitial Thermal Therapy (LITT) as Palliative Treatment for Patients with Malignant Glioma Requiring Standard Treatment Alternatives
Phase: N/A
Sponsor: PI initiated
Principal Investigator: Peter Fecci
Contact: The Preseton Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00079623

INTERCEPT: INTracerebral EGFR-vIII Chimeric Antigen Receptor Gene-Modified T CElls for PaTients with Recurrent GBM
Phase: Phase I
Sponsor: Internal Investigator Initiated Therapeutic &/or Interventional
Principal Investigator: Daniel Landi
Contact: Preston Robert Tisch Brain Tumor Research Center
Phone: 919.684.5301
Reference Number: 00083828
View this trial at ClinicalTrials.gov

Assessing the Impact of Glioblastoma Multiforme on the Quality of Life of Patients and Caregivers (The GlioQoL Observational Study) (AbbVie H15-ONC-22)
Phase: N/A
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Katherine Peters
Contact: Preston Robert Tisch Brain Tumor Center
Phone: 919.684.5301
Reference Number: 00085581