Adult Clinical Trials

Lung Cancer

If you need additional information about any of the trials listed or would like to inquire about other open trials, please contact the Lung/ Thoracic Clinical Trials Office at 919.681.4768.

15 trials identified.

Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin or Carboplatin and Etoposide.
Phase: Phase III
Sponsor: Cooperative Group Initiated
Principal Investigator: Jeffrey Crawford
Contact: Thoracic Oncology Research Office
Phone: 919.681.4768
Reference Number: 00007332
View this trial at ClinicalTrials.gov

SWOG S1400: A Biomarker-Driven Master Protocol for Previously Treated Squamous Cell Lung Cancer (Lung-MAP)
Phase: Phase III
Sponsor: Cooperative Group Initiated
Principal Investigator: Jeffrey Crawford
Contact: Thoracic Oncology Research Office
Phone: 919.681.4768
Reference Number: 00057165
View this trial at ClinicalTrials.gov

Alliance A151216: Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)
Phase: N/A
Sponsor: Cooperative Group Initiated
Principal Investigator: Jeffrey Crawford
Contact: Thoracic Oncology Research Office
Phone: 919.681.4768
Reference Number: 00057971
View this trial at ClinicalTrials.gov

Alliance A081105: Randomized Study of Erlotinib versus Observation in Patients with Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Cell Lung Cancer (NSCLC)
Phase: Phase III
Sponsor: Cooperative Group Initiated
Principal Investigator: Jeffrey Crawford
Contact: Thoracic Oncology Research Office
Phone: 919.681.4768
Reference Number: 00057973
View this trial at ClinicalTrials.gov

ECOG-ACRIN E4512: A Randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib Versus Observation for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein
Phase: Phase III
Sponsor: Cooperative Group Initiated
Principal Investigator: Jeffrey Crawford
Contact: Thoracic Oncology Research Office
Phone: 919.681.4768
Reference Number: 00060199
View this trial at ClinicalTrials.gov

Duke Thoracic, Head and Neck Biomarkers and Epidemiology Study
Phase: N/A
Sponsor: Internal Investigator Initiated Non-therapeutic/Non-interventional
Principal Investigator: Qingyi Wei
Contact: Epidemiology Oncology Research Team
Phone: 919.668.5691
Reference Number: 00072532

EA5142: Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers
Phase: Phase III
Sponsor: Cooperative Group Initiated
Principal Investigator: Jeffrey Crawford
Contact: Thoracic Oncology Clinical Trials Office
Phone: 919.681.4768
Reference Number: 00073268
View this trial at ClinicalTrials.gov

Phase II trial of brigatinib after treatment with second-generation ALK inhibitors in refractory ALK rearranged NSCLC
Phase: Phase II
Sponsor: Internal Investigator Initiated Therapeutic &/or Interventional
Principal Investigator: Thomas Stinchcombe
Contact: Thoracic Oncology Clinical Trials Office
Phone: 919.681.4768
Reference Number: 00074492
View this trial at ClinicalTrials.gov

A Phase IIIb/IV Safety Trial of Flat Dose Nivolumab in Combination with Ipilimumab in participants with Non-Small Cell Lung Cancer
Phase: Phase III
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Neal Ready
Contact: Thoracic Oncology Clinical Trials Office
Phone: 919.681.4768
Reference Number: 00075721
View this trial at ClinicalTrials.gov

A Phase 1 Dose Escalation and Phase 2 Randomized, Open-Label Study of Nivolumab and Veliparib in Combination with Platinum Doublet Chemotherapy in Subjects with Metastatic or Advanced Non-Small Cell Lung Cancer (NSCLC)
Phase: Phase I
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Jeffrey Clarke
Contact: Thoracic Oncology Clinical Trials Office
Phone: 919.681.4768
Reference Number: 00076809
View this trial at ClinicalTrials.gov

A randomized phase II study evaluating pembrolizumab vs topotecan in the second-line treatment of patients with small cell lung cancer.
Phase: Phase II
Sponsor: Foundation (non-profit group) initiated
Principal Investigator: Thomas Stinchcombe
Contact: Thoracic Oncology Clinical Trials Office
Phone: 919.681.4768
Reference Number: 00079547
View this trial at ClinicalTrials.gov

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First-Line Platinum-Based Chemotherapy in Subjects with Extensive Stage Small Cell Lung Cancer (MERU)
Phase: Phase III
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Neal Ready
Contact: THORACIC ONCOLOGY CLINICAL TRIALS OFFICE
Phone: 919.681.4768
Reference Number: 00079614
View this trial at ClinicalTrials.gov

A Phase III, Randomized, Double-Blind, Placebo-controlled Trial of Pembrolizumab (MK3475/SCH900475) in Combination with Etoposide/Platinum (Cisplatin or Carboplatin) for the First-line Treatment of Subjects with Extensive Stage Small Cell Lung Cancer (KEYNOTE-604)
Phase: Phase III
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Thomas Stinchcombe
Contact: Thoracic Oncology Clinical Trials Office
Phone: 919.681.4768
Reference Number: 00080648
View this trial at ClinicalTrials.gov

A Phase 1/2 Study on the Safety of Rovalpituzumab Tesirine Administered in Combination with Nivolumab or Nivolumab and Ipilimumab for Adults with Extensive-Stage Small Cell Lung Cancer
Phase: Phase I
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Neal Ready
Contact: Thoracic Oncology Clinical Trials Office
Phone: 919.681.4768
Reference Number: 00081077
View this trial at ClinicalTrials.gov

A Phase 1 Study of the Highly-selective RET Inhibitor, BLU-667, in Patients with Thyroid Cancer, Non-Small Cell Lung Cancer (NSCLC) and Other Advanced Solid Tumors
Phase: Phase I
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Thomas Stinchcombe
Contact: Thoracic Oncology Clinical Trials Office
Phone: 919.681.4768
Reference Number: 00084162
View this trial at ClinicalTrials.gov