Adult Clinical Trials

Sarcomas- Cancers of the bones and soft body tissues

If you need additional information about any of the trials listed or would like to inquire about other open trials, please contact the Sarcoma Clinical Trials Office at 919.681.4768.

13 trials identified.

AEWS1031 A Phase III Randomized Trial of Adding Vincristine-Topotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma
Phase: Phase III
Sponsor: Cooperative Group Initiated
Principal Investigator: Susan Kreissman
Contact: Dr. Susan Kreissman
Phone: 919.684.3401
Reference Number: 00028814
View this trial at ClinicalTrials.gov

A Phase 1B Dose-Escalation and Phase 2A Study of TRC105 in Combination with Pazopanib in Patients with Advanced Soft Tissue Sarcoma
Phase: Phase I
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Richard Riedel
Contact: Sarcoma Oncology Research Office
Phone: 919.681.4768
Reference Number: 00050117
View this trial at ClinicalTrials.gov

SARC024: A blanket protocol to study oral regorafenib in patients with selected sarcoma subtypes
Phase: Phase II
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Richard Riedel
Contact: Sarcoma Oncology Clinical Trials Office
Phone: 919.681.4768
Reference Number: 00052320
View this trial at ClinicalTrials.gov

ARST1321 Pazopanib Neoadjuvant Trial In Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754, IND# 118613)
Phase: Phase II
Sponsor: Cooperative Group Initiated
Principal Investigator: Susan Kreissman
Contact: Dr. Susan Kreissman
Phone: 919.684.3401
Reference Number: 00056072
View this trial at ClinicalTrials.gov

A Phase 2 Multi-Center Investigation of Efficacy of ABI-009 (nab-rapamycin) in Patients with Advanced Malignant Perivascular Epithelioid Tumors (PEComa)
Phase: Phase II
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Richard Riedel
Contact: Sarcoma Oncology Clinical Trials Office
Phone: 919.681.1883
Reference Number: 00067600
View this trial at ClinicalTrials.gov

Alliance A091304: A Phase I/Randomized Phase II Study of MLN0128 versus Pazopanib in Patients with Locally Advanced/Unresectable and/or Metastatic Sarcoma
Phase: Phase I
Sponsor: Cooperative Group Initiated
Principal Investigator: Jeffrey Crawford
Contact: Sarcoma Oncology Clinical Trials Office
Phone: 919.681.1883
Reference Number: 00069057
View this trial at ClinicalTrials.gov

A Randomized, Open-Label, Phase 2 Trial of CMB305 (Sequentially Administered LV305 and G305) and Atezolizumab in Patients with Locally Advanced, Relapsed, or Metastatic Sarcoma Expressing NY-ESO-1
Phase: Phase II
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Richard Riedel
Contact: Sarcoma Oncology Clinical Trials Office
Phone: 919.681.1883
Reference Number: 00069932
View this trial at ClinicalTrials.gov

A PHASE 2-3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND STUDY OF SELINEXOR (KPT-330) VERSUS PLACEBO IN PATIENTS WITH ADVANCED UNRESECTABLE DEDIFFERENTIATED LIPOSARCOMA (DDLS)
Phase: Phase II
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Richard Riedel
Contact: SARCOMA Clinical Trials Research Office
Phone: 919.681.1883
Reference Number: 00072155
View this trial at ClinicalTrials.gov

A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Trial of Crenolanib in Subjects with Advanced or Metastatic Gastrointestinal Stromal Tumors with a D842V Mutation in the PDGFRA Gene
Phase: Phase III
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Richard Riedel
Contact: SARCOMA ONCOLOGY CLINICAL TRIALS OFFICE
Phone: 919.681.1883
Reference Number: 00075745
View this trial at ClinicalTrials.gov

An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients with Locally Advanced or Metastatic Solid Tumors that Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
Phase: Phase II
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Richard Riedel
Contact: SARCOMA ONCOLOGY CLINICAL TRIALS OFFICE
Phone: 919.681.1883
Reference Number: 00078723
View this trial at ClinicalTrials.gov

A Randomized Phase 3 Trial of TRC105 and Pazopanib versus Pazopanib alone in Patients with Advanced Angiosarcoma (TAPPAS)
Phase: Phase III
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Richard Riedel
Contact: SARCOMA ONCOLOGY CLINICAL TRIALS OFFICE
Phone: 919.681.1883
Reference Number: 00080349
View this trial at ClinicalTrials.gov

A Phase 2 Randomized Controlled Trial of Neoadjuvant Pembrolizumab with Radiotherapy and Adjuvant Pembrolizumab in Patients with High-Risk, Localized Soft Tissue Sarcoma of the Extremity
Phase: Phase II
Sponsor: Foundation (non-profit group) initiated
Principal Investigator: Richard Riedel
Contact: SARCOMA ONCOLOGY CLINICAL TRIALS OFFICE
Phone: 919.681.1883
Reference Number: 00081828
View this trial at ClinicalTrials.gov

A Phase 1b/2 Dose-Escalation and Expansion Trial of NC-6300 (Nanoparticle Epirubicin) in Patients with Advanced Solid Tumors or Advanced, Metastatic, or Unresectable Soft Tissue Sarcoma
Phase: Phase I
Sponsor: Commercial / Industry (for-profit group) initiated
Principal Investigator: Richard Riedel
Contact: SARCOMA ONCOLOGY CLINICAL TRIALS OFFICE
Phone: 919.681.1883
Reference Number: 00082899
View this trial at ClinicalTrials.gov