We are doing this study to find out if an investigational drug called apalutamide (the study drug) is a safe and effective treatment for your form of cancer. We want to know how well people respond to the usual therapy (hormone therapy and radiation) in combination with the study drug compared to the usual therapy on its own.

Node-Positive Prostate Cancer after Radical Prostatectomy

Adults ages 18+ who:

• Are diagnosed with prostate adenocarcinoma
• Have pathologically node positive disease with nodal involvement only in the pelvis in the
  prostatectomy specimen

For more information about who can join this study, please contact the study team at brant.inman@duke.edu.

If you choose to join this study, you will be randomly assigned (like a coin flip) to 1 of 2 groups:

• One group will get the standard hormone drugs for up to 24 months plus radiation therapy for 5-8 weeks
• The other group will get the standard hormone drugs for up to 24 months, radiation therapy for 5-8 weeks, and the study drug for 24 months