Endocrine Neoplasia

Program Leadership

Randall Scheri, MD
Director

Overview

Our multidisciplinary disease group includes endocrine surgeons, endocrinologists, head and neck (ENT) surgeons, medical oncologists, radiation oncologists, a dedicated endocrine diagnostic radiology and pathology group, specialized advanced practice providers, nurses, social workers, nutritionists, genetic counselors and others.

We offer personalized therapies based on biopsies or small tissue samples as well as molecular testing, which means that treatments are tailored to the specific type of cancer.

Our surgeons have performed thousands of neck and abdominal endocrine-specific surgical procedures, ranging from minimally invasive to complex. Novel surgical techniques are employed, including parathyroid and thyroid surgery under local anesthesia and minimally invasive adrenal surgery through the back. Our endocrinologists are sub-specialized, focusing their entire clinical practice in treating all forms of endocrine neoplasia disease and working alongside surgeons to ensure optimal treatment pre-operatively, during surgery, and post-operatively.

We strive for lower complication rates, shorter hospital stays, lower overall costs, less likelihood of cancer recurrence and fewer repeat operations as compared to national published data.

Challenging cases are discussed in a multidisciplinary fashion at a weekly tumor board attended by experts from surgery, endocrinology, pathology, radiology and oncology.

We also offer patient support services to assist patients in maintaining quality of life throughout treatment and recovery. Both adult and pediatric patients have convenient and rapid access to appointments in both Raleigh and Durham Duke Cancer Center locations.

Treatment

As a National Cancer Institute-designated Comprehensive Cancer Center, our thyroid cancer group is recognized for exploring new treatment opportunities. We work with the American Thyroid Association, American Association of Endocrine Surgeons and National Comprehensive Center Network to help set the national standards for best practice treatment guidelines. We were also one of the first institutions to work with the Collaborative Endocrine Surgery Quality Improvement Program to improve quality in endocrine surgery.

Our disease group specializes in:

Diseases of the Thyroid

  • Thyroid cancer
  • Thyroid nodule/mass
  • Thyroid goiter
  • Toxic multinodular goiter
  • Toxic adenoma
  • Graves’ disease/Hyperthyroidism

LEARN MORE about our thyroid disease testing and treatments  
 
Parathyroid Disorders

  • Hyperparathyroidism (primary, secondary, tertiary, recurrent)
  • Parathyroid cancer
  • Parathyroid adenoma
  • Hypercalcemia

LEARN MORE about our testing and treatments for parathyroid disorders  
 
Adrenal Gland Disorders

  • Adrenal nodule/mass (functional or not)
  • Adrenal cancer
  • Pheochromoocytoma
  • Cushing’s Syndrome
  • Conn’s Syndrome
  • Pheochromocytoma or hyperaldosteronism
  • Primary aldosteronism

LEARN MORE about our testing and treatments for adrenal gland disorders 

Download our Duke Cancer Patient Resource Guide 

Make An Appointment

To make an appointment, please call 888.275.3853. For more information on endocrine system cancer care at Duke Health, visit:

To find a doctor, visit Find A Specialist. For more information on cancer care at Duke Health, visit Thyroid Cancer Care at Duke Health. To find a doctor, visit Find A Specialist

 

Research

Our research encompasses the different diseases of the thyroid, parathyroid, pancreas, and adrenal glands. 

Our Focus: 

  • Health Services Research
  • Patient-Reported Outcomes
  • Translational Research: The endocrine neoplasia group has an encompassing interest in cross-disciplinary translational research, including parathyroid diseases (Koh Laboratory), and thyroid cancer (Counter Laboratory; Stapleton Laboratory)  
  • Cancer Genetics: The endocrine neoplasia group has been working using genomic data of thyroid cancer, to develop a genetic signature that predicts progression. (Cheng Laboratory) 
  • Clinical Trials 

Research Programs and Centers:

           :: Duke Endocrine Neoplasia Research Group      :: DCRI       :: Duke SCORES

Clinical Trials

We are among the first to enroll patients in clinical studies investigating small-molecule therapies for locally advanced and metastatic thyroid cancer. Our expanding portfolio of clinical trials and growing tissue bank opens our patients’ access to experimental uses of approved drugs and newer therapies, including selumetinib, vandetanib (Caprelsa), cabozantinib (Cometriq) and sorafenib (Nexavar).

SEARCH OUR CLINICAL TRIALS

Additional Contacts

Nolan Miller, Administrative Director
Phone: 919.684.1671 

Publications

Robinson, TJ, Thomas, S, Dinan, MA, Roman, S, Sosa, JA, and Hyslop, T. "How Many Lymph Nodes Are Enough? Assessing the Adequacy of Lymph Node Yield for Papillary Thyroid Cancer."   Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology 34, no. 28 (October 2016): 3434-3439.  PMID: 27528716

Goffredo, P, Robinson, TJ, Youngwirth, LM, Roman, SA, and Sosa, JA. "Intensity-modulated radiation therapy use for the localized treatment of thyroid cancer: Nationwide practice patterns and outcomes."  Endocrine 53, no. 3 (September 2016): 761-773.  PMID: 27025947

Anderson, KL, Youngwirth, LM, Scheri, RP, Stang, MT, Roman, SA, and Sosa, JA. "T1a Versus T1b Differentiated Thyroid Cancers: Do We Need to Make the Distinction?."  Thyroid: official journal of the American Thyroid Association 26, no. 8 (August 2016): 1046-1052.  PMID: 27266722

Pontius, LN, Youngwirth, LM, Thomas, SM, Scheri, RP, Roman, SA, and Sosa, JA. "Lymphovascular invasion is associated with survival for papillary thyroid cancer."  Endocrine-Related Cancer 23, no. 7 (July 2016): 555-562.  PMID: 27317633

Jillard, CL, Youngwirth, L, Scheri, RP, Roman, S, and Sosa, JA. "Radioactive Iodine Treatment Is Associated with Improved Survival for Patients with Hürthle Cell Carcinoma."  Thyroid: official journal of the American Thyroid Association 26, no. 7 (July 2016): 959-964.  PMID: 27150319

Ruel, E, Thomas, S, Dinan, MA, Perkins, JM, Roman, SA, and Sosa, JA. "Knowledge of pathologically versus clinically negative lymph nodes is associated with reduced use of radioactive iodine post-thyroidectomy for low-risk papillary thyroid cancer."  Endocrine 52, no. 3 (June 2016): 579-586.  PMID: 26708045

Adam, MA, Thomas, S, Youngwirth, L, Hyslop, T, Reed, SD, Scheri, RP, Roman, SA, and Sosa, JA. "Is There a Minimum Number of Thyroidectomies a Surgeon Should Perform to Optimize Patient Outcomes?"  Annals of Surgery (March 8, 2016).  PMID: 26967630

Youngwirth, LM, Adam, MA, Scheri, RP, Roman, SA, and Sosa, JA. "Patients Treated at Low-Volume Centers have Higher Rates of Incomplete Resection and Compromised Outcomes: Analysis of 31,129 Patients with Papillary Thyroid Cancer."   Annals of Surgical Oncology 23, no. 2 (February 2016): 403-409.  PMID: 26416710

Adam, MA, Goffredo, P, Youngwirth, L, Scheri, RP, Roman, SA, and Sosa, JA. "Same thyroid cancer, different national practice guidelines: When discordant American Thyroid Association and National Comprehensive Cancer Network surgery recommendations are associated with compromised patient outcome."  Surgery 159, no. 1 (January 2016): 41-50.  PMID: 26435426  

 

Englum, BR, Pura, J, Reed, SD, Roman, SA, Sosa, JA, and Scheri, RP. "A Bedside Risk Calculator to Preoperatively Distinguish Follicular Thyroid Carcinoma from Follicular Variant of Papillary Thyroid Carcinoma."  World Journal of Surgery 39, no. 12 (December 2015): 2928-2934.  PMID 26324158

Goffredo, P, Thomas, SM, Adam, MA, Sosa, JA, and Roman, SA. "Impact of Timeliness of Resection and Thyroidectomy Margin Status on Survival for Patients with Anaplastic Thyroid Cancer: An Analysis of 335 Cases."  Annals of Surgical Oncology 22, no. 13 (December 2015): 4166-4174.  PMID: 26271394

Adam, MA, Pura, J, Goffredo, P, Dinan, MA, Reed, SD, Scheri, RP, Hyslop, T, Roman, SA, and Sosa, JA. "Presence and Number of Lymph Node Metastases Are Associated With Compromised Survival for Patients Younger Than Age 45 Years With Papillary Thyroid Cancer."  Journal of Clinical Oncology: official journal of the American Society of Clinical Oncology 33, no. 21 (July 2015): 2370-2375.  PMID: 26077238

Goffredo, P, Thomas, SM, Dinan, MA, Perkins, JM, Roman, SA, and Sosa, JA. "Patterns of use and cost for inappropriate radioactive iodine treatment for thyroid cancer in the United States: use and misuse."  JAMA Internal Medicine 175, no. 4 (April 2015): 638-640.  PMID: 25686394 

Adam, MA, Pura, J, Goffredo, P, Dinan, MA, Hyslop, T, Reed, SD, Scheri, RP, Roman, SA, and Sosa, JA. "Impact of extent of surgery on survival for papillary thyroid cancer patients younger than 45 years."  The Journal of Clinical Endocrinology and Metabolism 100, no. 1 (January 2015): 115-121.  PMID: 25337927

Adam, MA, Speicher, P, Pura, J, Dinan, MA, Reed, SD, Roman, SA, and Sosa, JA. "Robotic thyroidectomy for cancer in the US: patterns of use and short-term outcomes."  Annals of Surgical Oncology 21, no. 12 (November 2014): 3859-3864.  PMID: 24934584

Adam, MA, Pura, J, Gu, L, Dinan, MA, Tyler, DS, Reed, SD, Scheri, R, Roman, SA, and Sosa, JA. "Extent of surgery for papillary thyroid cancer is not associated with survival: an analysis of 61,775 patients."  Annals of Surgery 260, no. 4 (October 2014): 601-605.  PMID: 25203876

Wang, TS, Goffredo, P, Sosa, JA, and Roman, SA. "Papillary thyroid microcarcinoma: an over-treated malignancy?"  World Journal of Surgery 38, no. 9 (September 2014): 2297-2303.  PMID: 24791670

Goffredo, P, Roman, SA, and Sosa, JA.  "Have 2006 ATA practice guidelines affected the treatment of differentiated thyroid cancer in the United States?."  Thyroid: official journal of the American Thyroid Association 24, no. 3 (March 2014): 463-471.  PMID: 23978295

Sosa, JA, Hanna, JW, Robinson, KA, and Lanman, RB. "Increases in thyroid nodule fine-needle aspirations, operations, and diagnoses of thyroid cancer in the United States."  Surgery 154, no. 6 (December 2013): 1420-1426PMID: 24094448

Nussbaum, DP, Adam, MA, Youngwirth, LM, Ganapathi, AM, Roman, SA, Tyler, DS, Sosa, JA, and III, BDG. "Minimally Invasive Pancreaticoduodenectomy Does Not Improve Use or Time to Initiation of Adjuvant Chemotherapy for Patients With Pancreatic Adenocarcinoma."  Annals of Surgical Oncology 23, no. 3 (March 2016): 1026-1033.  PMID: 26542590

Adam, MA, Choudhury, K, Goffredo, P, Reed, SD, Blazer, D, Roman, SA, and Sosa, JA. "Minimally Invasive Distal Pancreatectomy for Cancer: Short-Term Oncologic Outcomes in 1,733 Patients."  World Journal of Surgery 39, no. 10 (October 2015): 2564-2572.  PMID: 26154576

Adam, MA, Choudhury, K, Dinan, MA, Reed, SD, Scheri, RP, Blazer, DG, Roman, SA, and Sosa, JA. "Minimally Invasive Versus Open Pancreaticoduodenectomy for Cancer: Practice Patterns and Short-term Outcomes Among 7061 Patients."  Annals of Surgery 262, no. 2 (August 2015): 372-377.  PMID: 26158612

Gratian, L, Pura, J, Dinan, M, Roman, S, Reed, S, and Sosa, JA. "Impact of extent of surgery on survival in patients with small nonfunctional pancreatic neuroendocrine tumors in the United States."  Annals of Surgical Oncology 21, no. 11 (October 2014): 3515-3521.  PMID: 24841347

Gratian, L, Pura, J, Dinan, M, Reed, S, Scheri, R, Roman, S, and Sosa, JA. "Treatment patterns and outcomes for patients with adrenocortical carcinoma associated with hospital case volume in the United States."  Annals of Surgical Oncology21, no. 11 (October 2014): 3509-3514.  PMID: 25069860

Kazaure, HS, Roman, SA, Tyler, D, and Sosa, JA. "The significance of atrial fibrillation in patients aged ≥ 55 years undergoing abdominal surgery."  World Journal of Surgery 39, no. 1 (January 2015): 113-120.  PMID: 25223740

Kazaure, HS, Roman, SA, and Sosa, JA. "A population-level analysis of 5620 recipients of multiple in-hospital cardiopulmonary resuscitation attempts." Journal of Hospital Medicine 9, no. 1 (January 1, 2014): 29-34.  PMID: 24311461

Chen, MM, Yeo, HL, Roman, SA, Bell, RH, and Sosa, JA. "Life events during surgical residency have different effects on women and men over time."  Surgery 154, no. 2 (August 2013): 162-170.  PMID: 23889946

Kazaure, HS, Roman, SA, Rosenthal, RA, and Sosa, JA. "Cardiac arrest among surgical patients: an analysis of incidence, patient characteristics, and outcomes in ACS-NSQIP."  JAMA Surgery 148, no. 1 (January 2013): 14-21.  PMID: 23324834