Hal Charles

Overview:



Dr. Charles is an Associate Professor of Radiology, a chemist and an expert in MR imaging and spectroscopy with over 40 years of experience in nuclear magnetic resonance. He serves as the Scientific Director of the Duke Center for Advanced Magnetic Resonance Development.  He has had extensive experience in conducting longitudinal clinical trials with MRI and MRS used as imaging biomarkers. He is also director of the Duke Image Analysis Laboratory which is active in conducting clinical trials in CNS disorders (schizophrenia, MCI, AD), cancer, osteoarthritis and lung disease using imaging based biomarkers. His lab has developed approaches for imaging lung function (ventilation and V/Q) in humans with 19F MRI.

Positions:

Associate Professor of Radiology

Radiology
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

Ph.D. 1981

University of New Orleans

Grants:

Hyperthermia And Perfusion Effects In Cancer Therapy

Administered By
Radiation Oncology
Awarded By
National Institutes of Health
Role
Co-Principal Investigator
Start Date
End Date

Hyperthermia And Perfusion Effects In Cancer Therapy

Administered By
Radiation Oncology
Awarded By
National Institutes of Health
Role
Co-Principal Investigator
Start Date
End Date

Hyperthermia And Perfusion Effects In Cancer Therapy

Administered By
Radiation Oncology
Awarded By
National Institutes of Health
Role
Co-Principal Investigator
Start Date
End Date

Human Lung Regional Ventilation Defect Severity Measured by Fluorine-19 Gas MRI

Administered By
Radiology
Awarded By
National Institutes of Health
Role
Principal Investigator
Start Date
End Date

Adolescent Alcohol Abuse, PTSD & Hippocampal Development

Administered By
Psychiatry, Child & Family Mental Health & Community Psychiatry
Awarded By
National Institutes of Health
Role
Co Investigator
Start Date
End Date

Publications:

In-Vivo Visualization Of Slow To Fast Filling Compartments In Human Lungs Using 19f Mri Of Perfluorinated Gases Mixed With Oxygen

Authors
Charles, HC; MacIntyre, NR; Moon, R; Foster, WM; McAdams, HP; Ainslie, M
MLA Citation
Charles, H. C., et al. “In-Vivo Visualization Of Slow To Fast Filling Compartments In Human Lungs Using 19f Mri Of Perfluorinated Gases Mixed With Oxygen.” American Journal of Respiratory and Critical Care Medicine, vol. 189, AMER THORACIC SOC, Jan. 2014.
URI
https://scholars.duke.edu/individual/pub1169484
Source
wos
Published In
American Journal of Respiratory and Critical Care Medicine
Volume
189
Published Date

Improved attention is associated with reductions in frontal lobe lactate levels in first episode psychosis

Authors
Yurgelun-Todd, DA; Renshaw, PF; Wei, H; Keefe, RS; Charles, HC; Tohen, M; Liebermann, JA
MLA Citation
Yurgelun-Todd, D. A., et al. “Improved attention is associated with reductions in frontal lobe lactate levels in first episode psychosis.” Schizophrenia Research, vol. 60, no. 1, Elsevier BV, 2003, pp. 318–318. Crossref, doi:10.1016/s0920-9964(03)80271-2.
URI
https://scholars.duke.edu/individual/pub1470331
Source
crossref
Published In
Schizophrenia Research
Volume
60
Published Date
Start Page
318
End Page
318
DOI
10.1016/s0920-9964(03)80271-2

Physiorack: An Mri Safe/conditional Gas Delivery, Subject Monitoring And Respiratory Gating Solution For Real-Time Assessments Of Global Function During Imaging Sessions

Authors
Halaweish, AF; Charles, HC
MLA Citation
Halaweish, A. F., and H. C. Charles. “Physiorack: An Mri Safe/conditional Gas Delivery, Subject Monitoring And Respiratory Gating Solution For Real-Time Assessments Of Global Function During Imaging Sessions.” American Journal of Respiratory and Critical Care Medicine, vol. 187, AMER THORACIC SOC, 2013.
URI
https://scholars.duke.edu/individual/pub1175492
Source
wos
Published In
American Journal of Respiratory and Critical Care Medicine
Volume
187
Published Date

Effect of gait and velocity on in-vivo tibial loading in humans

Authors
Hora, M; Pontzer, H; Defrate, LE; Charles, HC; Sladek, V; Mcginnis, A
MLA Citation
Hora, Martin, et al. “Effect of gait and velocity on in-vivo tibial loading in humans.” American Journal of Physical Anthropology, vol. 171, WILEY, 2020, pp. 124–124.
URI
https://scholars.duke.edu/individual/pub1435129
Source
wos
Published In
American Journal of Physical Anthropology
Volume
171
Published Date
Start Page
124
End Page
124

Multi-Breath Steady-State Ventilation Distribution Via 19fluorine-Enhanced Mri

Authors
Halaweish, AF; Foster, WM; Moon, RD; MacIntyre, NR; MacFall, JR; Charles, HC
MLA Citation
Halaweish, A. F., et al. “Multi-Breath Steady-State Ventilation Distribution Via 19fluorine-Enhanced Mri.” American Journal of Respiratory and Critical Care Medicine, vol. 187, AMER THORACIC SOC, 2013.
URI
https://scholars.duke.edu/individual/pub1175493
Source
wos
Published In
American Journal of Respiratory and Critical Care Medicine
Volume
187
Published Date

Research Areas:

Activities of Daily Living
Adenine Nucleotides
Adenosine Triphosphate
Adipokines
Adipose Tissue
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Aging
Alleles
Alzheimer Disease
Analysis of Variance
Animals
Antineoplastic Combined Chemotherapy Protocols
Apolipoprotein E4
Apolipoproteins E
Arthrography
Aspartic Acid
Asthma
Atrophy
Attention Deficit Disorder with Hyperactivity
Autistic Disorder
Autopsy
Biological Markers
Blood Glucose
Body Mass Index
Body Temperature
Bone Malalignment
Bone Neoplasms
Brain
Brain Chemistry
Brain Diseases
Breast Neoplasms
Calibration
Cartilage
Cartilage, Articular
Cerebral Ventricles
Chemical Phenomena
Chemistry
Child
Child, Preschool
Cholinesterase Inhibitors
Chromatography, High Pressure Liquid
Clinical Trials, Phase III as Topic
Cognition
Cognition Disorders
Cohort Studies
Coloring Agents
Combined Modality Therapy
Contrast Media
Creatine
Cross-Sectional Studies
Cystic Fibrosis
Deoxyglucose
Depressive Disorder
Developmental Disabilities
Diabetic Retinopathy
Diagnosis, Computer-Assisted
Diagnosis, Differential
Diagnostic Imaging
Diffusion
Disease Models, Animal
Disease Progression
Disease-Free Survival
Dog Diseases
Dogs
Dose-Response Relationship, Radiation
Double-Blind Method
Drug Carriers
Drug Combinations
Echoencephalography
Edema
Electric Stimulation
Epidemiologic Methods
Equipment Design
Ethanolamines
Europe
Evaluation Studies as Topic
Exercise
Extracellular Space
Eye Diseases
False Negative Reactions
False Positive Reactions
Feasibility Studies
Female
Femur
Fetal Diseases
Fibrosis
Fluorine Radioisotopes
Fluorocarbons
Fluorodeoxyglucose F18
Follow-Up Studies
Forelimb
Fractals
Gadolinium DTPA
Genetic Predisposition to Disease
Genotype
Glaucoma
Glucose
Glycine
Hemodynamics
Hippocampus
Humans
Hydrogen
Hydrogen-Ion Concentration
Hyperthermia, Induced
Image Enhancement
Image Interpretation, Computer-Assisted
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Indans
Infant
Inositol
International Cooperation
Internationality
Intracellular Fluid
Intraocular Pressure
Ischemia
Isotopes
Kaplan-Meier Estimate
Kidney
Kidney Transplantation
Knee Joint
Lactates
Lactic Acid
Laser Therapy
Leg
Lethal Dose 50
Light Coagulation
Liposomes
Longitudinal Studies
Lung
Lung Diseases
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Mathematics
Memory
Memory Disorders
Microelectrodes
Microscopy, Electron
Middle Aged
Models, Biological
Molecular Conformation
Monitoring, Physiologic
Multicenter Studies as Topic
Muscle Neoplasms
Muscle, Skeletal
Muscles
Necrosis
Neoplasm Transplantation
Neoplasms
Neurology
Neuroma, Acoustic
Neurons
Neuropsychological Tests
Nootropic Agents
Obesity
Observer Variation
Odds Ratio
Organophosphates
Osteoarthritis, Knee
Osteophyte
Oxygen
Oxygen Consumption
Pain
Partial Pressure
Patella
Phantoms, Imaging
Phenylcarbamates
Phobic Disorders
Phosphates
Phosphocreatine
Phosphorus
Phosphorus Compounds
Phosphorus Isotopes
Phosphorus Radioisotopes
Phosphorylcholine
Photometry
Piperidines
Placebos
Polarography
Postoperative Complications
Postoperative Period
Posture
Predictive Value of Tests
Prenatal Diagnosis
Prognosis
Prospective Studies
Protons
Psychiatric Status Rating Scales
Psychiatry
Quality Assurance, Health Care
Quality Control
ROC Curve
Radiation Injuries
Radiation Oncology
Radiation Tolerance
Radiotherapy
Radiotherapy Dosage
Randomized Controlled Trials as Topic
Rats
Reference Standards
Reference Values
Regional Blood Flow
Reproducibility of Results
Research
Research Design
Respiratory Physiological Phenomena
Retina
Retinal Detachment
Retinal Diseases
Retinal Vessels
Risk Factors
Sarcoma
Sarcoma, Experimental
Seizures
Sensitivity and Specificity
Serine
Severity of Illness Index
Sex Characteristics
Signal Processing, Computer-Assisted
Soft Tissue Neoplasms
Solubility
Statistics as Topic
Structure-Activity Relationship
Survival Analysis
Technology
Technology Assessment, Biomedical
Temperature
Tetrahydrofolates
Thermodynamics
Thermography
Thermometers
Tibia
Time Factors
Tomography, Emission-Computed
Treatment Outcome
Tremor
Triglycerides
Tumor Cells, Cultured
Tumor Markers, Biological
Urinary Bladder
Visual Acuity
Visual Fields
Vitrectomy
Vomiting
Water
Weight-Bearing
Young Adult