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Huang, Jiaoti

Overview:

I am a physician-scientist with clinical expertise in the pathologic diagnosis of genitourinary tumors including tumors of the prostate, bladder, kidney and testis. Another area of interest is gynecologic tumors. In my research laboratory we study prostate cancer, focusing on molecular mechanisms of carcinogenesis and tumor progression, as well as biomarkers, imaging and novel therapeutic strategies. In addition to patient care and research, I am also passionate about education. I have trained numerous residents, fellows, graduate students and postdocs.


Positions:

Professor of Pathology

Pathology
School of Medicine

Professor of Pharmacology and Cancer Biology

Pharmacology & Cancer Biology
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Chair

Pathology
School of Medicine

Education:

M.D. 1983

M.D. — Anhui Medical University (China)

Ph.D. 1991

Ph.D. — New York University

Grants:

Histologic and Immunohistochemical Biomarkers for Heavily Treated Metastatic Prostate Cancer

Administered By
Pathology
AwardedBy
National Institutes of Health
Role
Principal Investigator
Start Date
July 01, 2016
End Date
June 30, 2021

Novel Tumor Suppressive Role of Phosphodiesterases in Prostate Cancer

Administered By
Pathology
AwardedBy
Department of Defense
Role
Principal Investigator
Start Date
September 30, 2016
End Date
July 31, 2019

A novel strategy to identify prostate cancer biomarkers for patient management

Administered By
Pathology
AwardedBy
National Institutes of Health
Role
Principal Investigator
Start Date
July 01, 2013
End Date
May 31, 2018

: Identification of DNA methylation markers for risk of metastasis in localized prostate cancer

Administered By
Pathology
AwardedBy
Kaiser Permanente
Role
Principal Investigator
Start Date
January 01, 2016
End Date
December 31, 2016

Stand Up 2 Cancer West Coast Dream Team Grant

Administered By
Pathology
AwardedBy
University of San Francisco
Role
Principal Investigator
Start Date
January 01, 2013
End Date
December 31, 2016
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Publications:

Targeted Biopsy to Detect Gleason Score Upgrading during Active Surveillance for Men with Low versus Intermediate Risk Prostate Cancer.

We sought to determine the rate of upgrading to Gleason score 4 + 3 or greater using targeted biopsy for diagnosis and monitoring in men undergoing active surveillance of prostate cancer.Study subjects comprised all 259 men, including 196 with Gleason score 3 + 3 and 63 with Gleason score 3 + 4, who were diagnosed by magnetic resonance imaging/ultrasound fusion guided biopsy from 2009 to 2015 and underwent subsequent fusion biopsy for as long as 4 years of active surveillance. The primary end point was the discovery of Gleason score 4 + 3 or greater prostate cancer. Followup biopsies included targeting of positive sites, which were tracked in an Artemis™ device. Kaplan-Meier curves were generated to determine upgrading rates, stratified by initial Gleason score and prostate specific antigen density.Based on a Cox proportional hazard model, men with Gleason score 3 + 4 were 4.65 times more likely to have upgrading than men with an initial Gleason score of 3 + 3 at 3 years (p <0.01). By the third surveillance year 63% of men with Gleason score 3 + 4 had been upgraded compared with 18.0% who started with Gleason score 3 + 3 (p <0.01). Of all 33 upgrades 32 (97%) occurred at a magnetic resonance imaging visible or a tracked site of tumor, rather than at a previously negative systematic site. Independent predictors of upgrading were Gleason score 3 + 4, prostate specific antigen density 0.15 ng/ml/cm3 or greater and a grade 5 lesion on magnetic resonance imaging. The incidence rate ratio of upgrading (Gleason score 3 + 4 vs 3 + 3) was 4.25 per year of patient followup (p <0.01).During active surveillance of prostate cancer, targeting of tracked tumor foci by magnetic resonance imaging/ultrasound fusion biopsy allows for heightened detection of Gleason score 4 + 3 or greater cancers. Baseline variables directly related to important upgrading that warrant increased vigilance include Gleason score 3 + 4, prostate specific antigen density 0.15 ng/ml/cm3 or greater and grade 5 lesions on magnetic resonance imaging.

Authors
Nassiri, N; Margolis, DJ; Natarajan, S; Sharma, DS; Huang, J; Dorey, FJ; Marks, LS
MLA Citation
Nassiri, N, Margolis, DJ, Natarajan, S, Sharma, DS, Huang, J, Dorey, FJ, and Marks, LS. "Targeted Biopsy to Detect Gleason Score Upgrading during Active Surveillance for Men with Low versus Intermediate Risk Prostate Cancer." The Journal of urology 197.3 Pt 1 (March 2017): 632-639.
PMID
27639713
Source
epmc
Published In
The Journal of Urology
Volume
197
Issue
3 Pt 1
Publish Date
2017
Start Page
632
End Page
639
DOI
10.1016/j.juro.2016.09.070

Magnetic Resonance Imaging Underestimation of Prostate Cancer Geometry: Use of Patient Specific Molds to Correlate Images with Whole Mount Pathology.

We evaluated the accuracy of magnetic resonance imaging in determining the size and shape of localized prostate cancer.The subjects were 114 men who underwent multiparametric magnetic resonance imaging before radical prostatectomy with patient specific mold processing of the specimen from 2013 to 2015. T2-weighted images were used to contour the prostate capsule and cancer suspicious regions of interest. The contours were used to design and print 3-dimensional custom molds, which permitted alignment of excised prostates with magnetic resonance imaging scans. Tumors were reconstructed in 3 dimensions from digitized whole mount sections. Tumors were then matched with regions of interest and the relative geometries were compared.Of the 222 tumors evident on whole mount sections 118 had been identified on magnetic resonance imaging. For the 118 regions of interest mean volume was 0.8 cc and the longest 3-dimensional diameter was 17 mm. However, for matched pathological tumors, of which most were Gleason score 3 + 4 or greater, mean volume was 2.5 cc and the longest 3-dimensional diameter was 28 mm. The median tumor had a 13.5 mm maximal extent beyond the magnetic resonance imaging contour and 80% of cancer volume from matched tumors was outside region of interest boundaries. Size estimation was most accurate in the axial plane and least accurate along the base-apex axis.Magnetic resonance imaging consistently underestimates the size and extent of prostate tumors. Prostate cancer foci had an average diameter 11 mm longer and a volume 3 times greater than T2-weighted magnetic resonance imaging segmentations. These results may have important implications for the assessment and treatment of prostate cancer.

Authors
Priester, A; Natarajan, S; Khoshnoodi, P; Margolis, DJ; Raman, SS; Reiter, RE; Huang, J; Grundfest, W; Marks, LS
MLA Citation
Priester, A, Natarajan, S, Khoshnoodi, P, Margolis, DJ, Raman, SS, Reiter, RE, Huang, J, Grundfest, W, and Marks, LS. "Magnetic Resonance Imaging Underestimation of Prostate Cancer Geometry: Use of Patient Specific Molds to Correlate Images with Whole Mount Pathology." The Journal of urology 197.2 (February 2017): 320-326.
PMID
27484386
Source
epmc
Published In
The Journal of Urology
Volume
197
Issue
2
Publish Date
2017
Start Page
320
End Page
326
DOI
10.1016/j.juro.2016.07.084

Establishing the distribution of satellite lesions in intermediate- and high-risk prostate cancer: implications for focused radiotherapy.

In focused radiotherapy for prostate cancer (PC), a full dose of radiation is delivered to the index lesion while reduced dose is delivered to the remaining prostate to reduce morbidity. As PC is commonly multifocal, we investigated whether baseline clinical characteristics or multiparametric magnetic resonance imaging (mpMRI) may be useful to predict the actual pathologic distribution of PC in men with intermediate- or high-risk PC, which may better inform how to deliver focused radiotherapy.A retrospective single-institutional study was performed on 71 consecutive men with clinically localized, intermediate- or high-risk PC who underwent mpMRI followed by radical prostatectomy (RP) from January 2012 to December 2012. Logistic regression analysis was performed to evaluate preoperative predictors for satellite lesions. Performance characteristics of mpMRI to detect satellite lesions and the extent of prostate disease (one hemi-gland vs both) were also evaluated.In all, 50.7% had satellite lesions on mpMRI. On RP specimen analysis, 66.2% had satellite lesions and 55.3% of these satellite lesions had pathologic Gleason score (pGS)⩾3+4. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy for mpMRI detecting a satellite lesion being present in the RP specimen were 59.6%, 66.7%, 77.8%, 45.7% and 62.0%, respectively. The presence of MRI satellite lesions was the only preoperative predictor significantly associated with finding satellite lesions on final pathology (hazard ratio (HR), 2.95, P=0.040). There was agreement in 76.1% of the entire cohort for unilateral vs bilateral disease when incorporating both biopsy and mpMRI information and comparing with the RP specimen.In intermediate risk or greater PC, only the presence of mpMRI satellite lesions could predict for pathologic satellite lesions. While combining biopsy and mpMRI information may improve preoperative disease localization, the relatively high incidence of bilateral hemi-gland involvement with pGS ⩾7 satellite lesions makes it challenging to appropriately select men eligible for hemi-gland therapy.Prostate Cancer and Prostatic Diseases advance online publication, 31 January 2017; doi:10.1038/pcan.2016.75.

Authors
Hegde, JV; Margolis, DJ; Wang, P-C; Reiter, RE; Huang, J; Steinberg, ML; Kamrava, M
MLA Citation
Hegde, JV, Margolis, DJ, Wang, P-C, Reiter, RE, Huang, J, Steinberg, ML, and Kamrava, M. "Establishing the distribution of satellite lesions in intermediate- and high-risk prostate cancer: implications for focused radiotherapy." Prostate cancer and prostatic diseases (January 31, 2017).
PMID
28139757
Source
epmc
Published In
Prostate Cancer and Prostatic Diseases
Publish Date
2017
DOI
10.1038/pcan.2016.75

Alternative Splicing Provides a Novel Molecular Mechanism for Prostatic Small-cell Neuroendocrine Carcinoma.

Authors
Feng, N; Yin, Y; He, Y; Huang, J
MLA Citation
Feng, N, Yin, Y, He, Y, and Huang, J. "Alternative Splicing Provides a Novel Molecular Mechanism for Prostatic Small-cell Neuroendocrine Carcinoma." European urology 71.1 (January 2017): 79-80.
PMID
27481176
Source
epmc
Published In
European Urology
Volume
71
Issue
1
Publish Date
2017
Start Page
79
End Page
80
DOI
10.1016/j.eururo.2016.07.046

Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6.

It has been suggested that ETV6 serves as a tumor suppressor; however, its molecular regulation and cellular functions remain unclear. We used prostate cancer as a model system and demonstrated a molecular mechanism in which ETV6 can be regulated by epidermal growth factor receptor (EGFR) signaling through microRNA-96 (miR-96)-mediated downregulation. In addition, EGFR acts as a transcriptional coactivator that binds to the promoter of primary miR-96 and transcriptionally regulates miR-96 levels. We analyzed two sets of clinical prostate cancer samples, confirmed association patterns that were consistent with the EGFR-miR-96-ETV6 signaling model and demonstrated that the reduced ETV6 levels were associated with malignant prostate cancer. Based on results derived from multiple approaches, we identified the biological functions of ETV6 as a tumor suppressor that inhibits proliferation and metastasis in prostate cancer. We present a molecular mechanism in which EGFR activation leads to the induction of miR-96 expression and suppression of ETV6, which contributes to prostate cancer progression.

Authors
Tsai, Y-C; Chen, W-Y; Siu, MK; Tsai, H-Y; Yin, JJ; Huang, J; Liu, Y-N
MLA Citation
Tsai, Y-C, Chen, W-Y, Siu, MK, Tsai, H-Y, Yin, JJ, Huang, J, and Liu, Y-N. "Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6." Cancer letters 384 (January 2017): 1-8.
PMID
27746161
Source
epmc
Published In
Cancer Letters
Volume
384
Publish Date
2017
Start Page
1
End Page
8
DOI
10.1016/j.canlet.2016.10.014

Molecular Signature to Risk-Stratify Prostate Cancer of Intermediate Risk.

A new 30-gene signature has been described that separates prostate cancers of Gleason score ≤6 from those of Gleason score ≥8. It provides independent prognostic information for prostate cancers of intermediate risk (Gleason score of 7), which has the potential to stratify these patients into different risk groups. Clin Cancer Res; 23(1); 6-8. ©2016 AACRSee related article by Sinnott et al., p. 81.

Authors
Yin, Y; Zhang, Q; Zhang, H; He, Y; Huang, J
MLA Citation
Yin, Y, Zhang, Q, Zhang, H, He, Y, and Huang, J. "Molecular Signature to Risk-Stratify Prostate Cancer of Intermediate Risk." Clinical cancer research : an official journal of the American Association for Cancer Research 23.1 (January 2017): 6-8.
Website
http://hdl.handle.net/10161/13092
PMID
27803045
Source
epmc
Published In
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume
23
Issue
1
Publish Date
2017
Start Page
6
End Page
8
DOI
10.1158/1078-0432.ccr-16-2400

All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy

Authors
Yan, Y; Li, Z; Xu, X; Chen, C; Wei, W; Fan, M; Chen, X; Li, JJ; Wang, Y; Huang, J
MLA Citation
Yan, Y, Li, Z, Xu, X, Chen, C, Wei, W, Fan, M, Chen, X, Li, JJ, Wang, Y, and Huang, J. "All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy." BMC Complementary and Alternative Medicine 16.1 (December 2016).
Source
crossref
Published In
BMC Complementary and Alternative Medicine
Volume
16
Issue
1
Publish Date
2016
DOI
10.1186/s12906-016-1088-y

Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis.

Although the differentiation of oncogenically transformed basal progenitor cells is one of the key steps in prostate tumorigenesis, the mechanisms mediating this cellular process are still largely unknown. Here we demonstrate that an expanded p63+ and CK5+ basal/progenitor cell population, induced by the concomitant activation of oncogenic Kras(G12D) and androgen receptor (AR) signaling, underwent cell differentiation in vivo The differentiation process led to suppression of p63-expressing cells with a decreased number of CK5+ basal cells but an increase of CK8+ luminal tumorigenic cells and revealed a hierarchal lineage pattern consisting of p63+/CK5+ progenitor, CK5+/CK8+ transitional progenitor, and CK8+ differentiated luminal cells. Further analysis of the phenotype showed that Kras-AR axis-induced tumorigenesis was mediated by Gli transcription factors. Combined blocking of the activators of this family of proteins (Gli1 and Gli2) inhibited the proliferation of p63+ and CK5+ basal/progenitor cells and development of tumors. Finally, we identified that Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63+ cells in Kras-AR driven tumors. Gli2, but not Gli1, transcriptionally regulated the expression levels of p63 and prostate sphere formation. Our study provides evidence of a novel mechanism mediating pathological dysregulation of basal/progenitor cells through the differential activation of the Gli transcription factors. Also, these findings define Gli proteins as new downstream mediators of the Kras-AR axis in prostate carcinogenesis and open a potential therapeutic avenue of targeting prostate cancer progression by inhibiting Gli signaling.

Authors
Wu, M; Ingram, L; Tolosa, EJ; Vera, RE; Li, Q; Kim, S; Ma, Y; Spyropoulos, DD; Beharry, Z; Huang, J; Fernandez-Zapico, ME; Cai, H
MLA Citation
Wu, M, Ingram, L, Tolosa, EJ, Vera, RE, Li, Q, Kim, S, Ma, Y, Spyropoulos, DD, Beharry, Z, Huang, J, Fernandez-Zapico, ME, and Cai, H. "Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis." The Journal of biological chemistry 291.49 (December 2016): 25749-25760.
PMID
27760825
Source
epmc
Published In
The Journal of biological chemistry
Volume
291
Issue
49
Publish Date
2016
Start Page
25749
End Page
25760

Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer: Update on the Stand Up 2 Cancer/Prostate Cancer Foundation–Supported West Coast Prostate Cancer Dream Team

Authors
Aggarwal, R; Beer, TM; Gleave, M; Stuart, JM; Rettig, M; Evans, CP; Youngren, J; Alumkal, JJ; Huang, J; Thomas, G; Witte, O; Small, EJ
MLA Citation
Aggarwal, R, Beer, TM, Gleave, M, Stuart, JM, Rettig, M, Evans, CP, Youngren, J, Alumkal, JJ, Huang, J, Thomas, G, Witte, O, and Small, EJ. "Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer: Update on the Stand Up 2 Cancer/Prostate Cancer Foundation–Supported West Coast Prostate Cancer Dream Team." European Urology Focus 2.5 (December 2016): 469-471.
Source
crossref
Published In
European urology focus
Volume
2
Issue
5
Publish Date
2016
Start Page
469
End Page
471
DOI
10.1016/j.euf.2016.10.011

Alternative splicing of EZH2 pre-mRNA by SF3B3 contributes to the tumorigenic potential of renal cancer.

Deregulation or mutation of the EZH2 gene causes various tumors, including ccRCC. Although several splice variants of EZH2 have been identified, little is known about how EZH2 splicing is regulated or the contribution of alternative splicing to its pro-tumorigenic functions.We conducted RT-PCR, western blot and immunohistochemistry techniques, to examine EZH2 and its alternative splicing transcript expression in renal cancer tissue and renal cancer cell lines. Proliferation, migration, clonogenicity and tumorigenicity of renal cancer cells either exhibiting knock-down of EZH2 or its splicing factor SF3B3 were assessed by CCK8, Transwell, and murine xenograft experiments.We found that inclusion of alternative EZH2 exon 14 was significantly increased in ccRCC samples and renal cancer cell lines. In ccRCC lines, enforced expression of EZH2(Delta)14 inhibited, and EZH2 promoted, cell growth, migration, proliferation and tumorigenicity in a xenograft model. Mechanistic studies demonstrated that EZH2(Delta)14 isoform functions as a dominant-negative inhibitor of full-length EZH2. Coexpression of EZH2(Delta)14 variant with full-length EZH2 not only abrogated DAB2IP and HOXA9 suppression but also inhibited EZH2-driven tumorigenesis. Strikingly, the splicing factor SF3B3 stimulates inclusion of exon14 and has pro-proliferative activity. Importantly, the upregulation of SF3B3 expression observed in clinical ccRCC samples parallels the increased inclusion of EZH2 exon14, and the SF3B3 level is associated with higher tumor stage and poor overall survival.These results suggest that SF3B3 as a key regulator of EZH2 pre-mRNA splicing and SF3B3 may represent a novel prognostic factor and potential therapeutic target in ccRCC.

Authors
Chen, K; Xiao, H; Zeng, J; Yu, G; Zhou, H; Huang, C; Yao, W; Xiao, W; Hu, J; Guan, W; Wu, L; Huang, J; Huang, Q; Xu, H; Ye, Z
MLA Citation
Chen, K, Xiao, H, Zeng, J, Yu, G, Zhou, H, Huang, C, Yao, W, Xiao, W, Hu, J, Guan, W, Wu, L, Huang, J, Huang, Q, Xu, H, and Ye, Z. "Alternative splicing of EZH2 pre-mRNA by SF3B3 contributes to the tumorigenic potential of renal cancer." Clinical cancer research : an official journal of the American Association for Cancer Research (November 22, 2016).
PMID
27879367
Source
epmc
Published In
Clinical cancer research : an official journal of the American Association for Cancer Research
Publish Date
2016

Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer.

To determine whether MRI/ultrasound (MRI/US) fusion biopsy facilitates longitudinal resampling of the same clonal focus of prostate cancer and to determine whether high-grade cancers can evolve from low-grade clones.All men on active surveillance who underwent tracking MRI/US fusion biopsy of Gleason 6 prostate cancer, on at least two distinct occasions, between 2012 and 2014 were enrolled. MRI/US fusion was used to track and resample specific cancer foci. IHC for ERG and targeted RNA/DNA next-generation sequencing (NGS) were performed on formalin-fixed paraffin-embedded prostate biopsy specimens to assess clonality.Thirty-one men with median age and PSA of 65 years and 4.6 ng/mL, respectively, were analyzed. The median sampling interval was 12 months (range, 5-35). Of the 26 evaluable men, ERG IHC concordance was found between initial and repeat biopsies in 25 (96%), indicating resampling of the same clonal focus over time. Targeted NGS supported ERG IHC results and identified unique and shared driving mutations, such as IDH1 and SPOP, in paired specimens. Of the nine men (34.6%) who were found to have Gleason ≥7 on repeat biopsy, all displayed temporal ERG concordance. Prioritized genetic alterations were detected in 50% (13/26) of paired samples. Oncogenic mutations were detected in 22% (2/9) of Gleason 6 cancers prior to progression and 44% (4/9) of Gleason ≥7 cancers when progression occurred.Precise tracking of prostate cancer foci via MRI/US fusion biopsy allowed subsequent resampling of the same clonal focus of cancer over time. Further research is needed to clarify the grade progression potential of Gleason 6 prostate cancer. Clin Cancer Res; 1-7. ©2016 AACR.

Authors
Palapattu, GS; Salami, SS; Cani, AK; Hovelson, DH; Lazo de la Vega, L; Vandenberg, KR; Bratley, JV; Liu, C-J; Kunju, LP; Montgomery, JS; Morgan, TM; Natarajan, S; Huang, J; Tomlins, SA; Marks, LS
MLA Citation
Palapattu, GS, Salami, SS, Cani, AK, Hovelson, DH, Lazo de la Vega, L, Vandenberg, KR, Bratley, JV, Liu, C-J, Kunju, LP, Montgomery, JS, Morgan, TM, Natarajan, S, Huang, J, Tomlins, SA, and Marks, LS. "Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research (October 7, 2016).
PMID
28031426
Source
epmc
Published In
Clinical cancer research : an official journal of the American Association for Cancer Research
Publish Date
2016
DOI
10.1158/1078-0432.ccr-16-1454

Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.

Metastatic castration-resistant prostate cancer (CRPC) is the primary cause of prostate cancer-specific mortality. Defining new mechanisms that can predict recurrence and drive lethal CRPC is critical. Here, we demonstrate that localized high-risk prostate cancer and metastatic CRPC, but not benign prostate tissues or low/intermediate-risk prostate cancer, express high levels of nuclear Notch homolog 1, translocation-associated (Notch1) receptor intracellular domain. Chronic activation of Notch1 synergizes with multiple oncogenic pathways altered in early disease to promote the development of prostate adenocarcinoma. These tumors display features of epithelial-to-mesenchymal transition, a cellular state associated with increased tumor aggressiveness. Consistent with its activation in clinical CRPC, tumors driven by Notch1 intracellular domain in combination with multiple pathways altered in prostate cancer are metastatic and resistant to androgen deprivation. Our study provides functional evidence that the Notch1 signaling axis synergizes with alternative pathways in promoting metastatic CRPC and may represent a new therapeutic target for advanced prostate cancer.

Authors
Stoyanova, T; Riedinger, M; Lin, S; Faltermeier, CM; Smith, BA; Zhang, KX; Going, CC; Goldstein, AS; Lee, JK; Drake, JM; Rice, MA; Hsu, E-C; Nowroozizadeh, B; Castor, B; Orellana, SY; Blum, SM; Cheng, D; Pienta, KJ; Reiter, RE; Pitteri, SJ; Huang, J; Witte, ON
MLA Citation
Stoyanova, T, Riedinger, M, Lin, S, Faltermeier, CM, Smith, BA, Zhang, KX, Going, CC, Goldstein, AS, Lee, JK, Drake, JM, Rice, MA, Hsu, E-C, Nowroozizadeh, B, Castor, B, Orellana, SY, Blum, SM, Cheng, D, Pienta, KJ, Reiter, RE, Pitteri, SJ, Huang, J, and Witte, ON. "Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer." Proceedings of the National Academy of Sciences of the United States of America 113.42 (October 2016): E6457-E6466.
PMID
27694579
Source
epmc
Published In
Proceedings of the National Academy of Sciences of USA
Volume
113
Issue
42
Publish Date
2016
Start Page
E6457
End Page
E6466

Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer.

We used clinical tissue from lethal metastatic castration-resistant prostate cancer (CRPC) patients obtained at rapid autopsy to evaluate diverse genomic, transcriptomic, and phosphoproteomic datasets for pathway analysis. Using Tied Diffusion through Interacting Events (TieDIE), we integrated differentially expressed master transcriptional regulators, functionally mutated genes, and differentially activated kinases in CRPC tissues to synthesize a robust signaling network consisting of druggable kinase pathways. Using MSigDB hallmark gene sets, six major signaling pathways with phosphorylation of several key residues were significantly enriched in CRPC tumors after incorporation of phosphoproteomic data. Individual autopsy profiles developed using these hallmarks revealed clinically relevant pathway information potentially suitable for patient stratification and targeted therapies in late stage prostate cancer. Here, we describe phosphorylation-based cancer hallmarks using integrated personalized signatures (pCHIPS) that shed light on the diversity of activated signaling pathways in metastatic CRPC while providing an integrative, pathway-based reference for drug prioritization in individual patients.

Authors
Drake, JM; Paull, EO; Graham, NA; Lee, JK; Smith, BA; Titz, B; Stoyanova, T; Faltermeier, CM; Uzunangelov, V; Carlin, DE; Fleming, DT; Wong, CK; Newton, Y; Sudha, S; Vashisht, AA; Huang, J; Wohlschlegel, JA; Graeber, TG; Witte, ON; Stuart, JM
MLA Citation
Drake, JM, Paull, EO, Graham, NA, Lee, JK, Smith, BA, Titz, B, Stoyanova, T, Faltermeier, CM, Uzunangelov, V, Carlin, DE, Fleming, DT, Wong, CK, Newton, Y, Sudha, S, Vashisht, AA, Huang, J, Wohlschlegel, JA, Graeber, TG, Witte, ON, and Stuart, JM. "Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer." Cell 166.4 (August 3, 2016): 1041-1054.
PMID
27499020
Source
epmc
Published In
Cell
Volume
166
Issue
4
Publish Date
2016
Start Page
1041
End Page
1054
DOI
10.1016/j.cell.2016.07.007

Focal Laser Ablation of Prostate Cancer: Phase I Clinical Trial

Authors
Natarajan, S; Raman, S; Priester, AM; Garritano, J; Margolis, DJA; Lieu, P; Macairan, ML; Huang, J; Grundfest, W; Marks, LS
MLA Citation
Natarajan, S, Raman, S, Priester, AM, Garritano, J, Margolis, DJA, Lieu, P, Macairan, ML, Huang, J, Grundfest, W, and Marks, LS. "Focal Laser Ablation of Prostate Cancer: Phase I Clinical Trial." The Journal of Urology 196.1 (July 2016): 68-75.
Source
crossref
Published In
The Journal of Urology
Volume
196
Issue
1
Publish Date
2016
Start Page
68
End Page
75
DOI
10.1016/j.juro.2015.12.083

Biased Expression of the FOXP3Δ3 Isoform in Aggressive Bladder Cancer Mediates Differentiation and Cisplatin Chemotherapy Resistance

Authors
Zhang, H; Prado, K; Zhang, KX; Peek, EM; Lee, J; Wang, X; Huang, J; Li, G; Pellegrini, M; Chin, AI
MLA Citation
Zhang, H, Prado, K, Zhang, KX, Peek, EM, Lee, J, Wang, X, Huang, J, Li, G, Pellegrini, M, and Chin, AI. "Biased Expression of the FOXP3Δ3 Isoform in Aggressive Bladder Cancer Mediates Differentiation and Cisplatin Chemotherapy Resistance." Clinical Cancer Research (May 17, 2016).
Source
manual
Published In
Clinical Cancer Research
Publish Date
2016

In-bore magnetic resonance-guided transrectal biopsy for the detection of clinically significant prostate cancer

Authors
Felker, ER; Lee-Felker, SA; Feller, J; Margolis, DJ; Lu, DS; Princenthal, R; May, S; Cohen, M; Huang, J; Yoshida, J; Greenwood, B; Kim, HJ; Raman, SS
MLA Citation
Felker, ER, Lee-Felker, SA, Feller, J, Margolis, DJ, Lu, DS, Princenthal, R, May, S, Cohen, M, Huang, J, Yoshida, J, Greenwood, B, Kim, HJ, and Raman, SS. "In-bore magnetic resonance-guided transrectal biopsy for the detection of clinically significant prostate cancer." Abdominal Radiology 41.5 (May 2016): 954-962.
Source
crossref
Published In
Abdominal radiology (New York)
Volume
41
Issue
5
Publish Date
2016
Start Page
954
End Page
962
DOI
10.1007/s00261-016-0750-7

Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay

Authors
Park, JW; Lee, JK; Phillips, JW; Huang, P; Cheng, D; Huang, J; Witte, ON
MLA Citation
Park, JW, Lee, JK, Phillips, JW, Huang, P, Cheng, D, Huang, J, and Witte, ON. "Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay." Proceedings of the National Academy of Sciences 113.16 (April 19, 2016): 4482-4487.
Source
crossref
Published In
Proceedings of the National Academy of Sciences of USA
Volume
113
Issue
16
Publish Date
2016
Start Page
4482
End Page
4487
DOI
10.1073/pnas.1603645113

Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay

Authors
Park, JW; Lee, JK; Phillips, JW; Huang, P; Cheng, D; Huang, J; Witte, ON
MLA Citation
Park, JW, Lee, JK, Phillips, JW, Huang, P, Cheng, D, Huang, J, and Witte, ON. "Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay." Proceedings of the National Academy of Sciences of USA 113.16 (April 19, 2016): 4482-4487.
Source
manual
Published In
Proceedings of the National Academy of Sciences of USA
Volume
113
Issue
16
Publish Date
2016
Start Page
4482
End Page
4487

The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma.

While prostatic adenocarcinomas are relatively indolent, some patients with advanced adenocarcinomas recur with small cell neuroendocrine carcinoma which is highly aggressive and lethal. Because glycolysis is a feature of malignancy and the degree of glycolysis generally correlates with tumor aggressiveness, we wanted to compare the metabolic differences and the molecular mechanisms involved between the two tumor types. In this study, and based on previous characterization, LNCaP and PC-3 prostate cancer cell lines were selected as models of prostatic adenocarcinoma and small cell neuroendocrine carcinoma, respectively. In addition to measuring glucose consumption, lactate secretion, and reactive oxygen species (ROS) levels, we performed metabolic profiling in these two model systems. The role of CD44 was studied by RNAi and lentivirus-mediated overexpression. Expression of key enzymes in glycolysis was studied using human tissue microarrays containing benign prostate, adenocarcinoma, and small cell neuroendocrine carcinoma. Results showed that glycolytic features of PC-3 cells were higher than that of LNCaP cells. PFKFB4 was overexpressed in human small cell carcinoma tissue versus adenocarcinoma tissue. CD44 regulated glucose metabolism, intracellular ROS, and cell proliferation in PC-3 cells. Inhibition of CD44 also sensitized PC-3 cells to carboplatin. In conclusion, this study suggests different pathways of glucose metabolism contribute to the disparate biologic behaviors of these two tumor types.CD44 is an important regulator of glucose metabolism in small cell neuroendocrine carcinoma and may be an important therapeutic target.

Authors
Li, W; Cohen, A; Sun, Y; Squires, J; Braas, D; Graeber, TG; Du, L; Li, G; Li, Z; Xu, X; Chen, X; Huang, J
MLA Citation
Li, W, Cohen, A, Sun, Y, Squires, J, Braas, D, Graeber, TG, Du, L, Li, G, Li, Z, Xu, X, Chen, X, and Huang, J. "The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma." Molecular cancer research : MCR 14.4 (April 2016): 344-353.
PMID
26832214
Source
epmc
Published In
Molecular cancer research : MCR
Volume
14
Issue
4
Publish Date
2016
Start Page
344
End Page
353
DOI
10.1158/1541-7786.mcr-15-0466

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells

Authors
Lee, JK; Phillips, JW; Smith, BA; Park, JW; Stoyanova, T; McCaffrey, EF; Baertsch, R; Sokolov, A; Meyerowitz, JG; Mathis, C; Cheng, D; Stuart, JM; Shokat, KM; Gustafson, WC; Huang, J; Witte, ON
MLA Citation
Lee, JK, Phillips, JW, Smith, BA, Park, JW, Stoyanova, T, McCaffrey, EF, Baertsch, R, Sokolov, A, Meyerowitz, JG, Mathis, C, Cheng, D, Stuart, JM, Shokat, KM, Gustafson, WC, Huang, J, and Witte, ON. "N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells." Cancer Cell 29.4 (April 2016): 536-547.
Source
crossref
Published In
Cancer Cell
Volume
29
Issue
4
Publish Date
2016
Start Page
536
End Page
547
DOI
10.1016/j.ccell.2016.03.001

Prostate cancer detection with magnetic resonance-ultrasound fusion biopsy: The role of systematic and targeted biopsies

Authors
Filson, CP; Natarajan, S; Margolis, DJA; Huang, J; Lieu, P; Dorey, FJ; Reiter, RE; Marks, LS
MLA Citation
Filson, CP, Natarajan, S, Margolis, DJA, Huang, J, Lieu, P, Dorey, FJ, Reiter, RE, and Marks, LS. "Prostate cancer detection with magnetic resonance-ultrasound fusion biopsy: The role of systematic and targeted biopsies." Cancer 122.6 (March 15, 2016): 884-892.
Source
crossref
Published In
Cancer
Volume
122
Issue
6
Publish Date
2016
Start Page
884
End Page
892
DOI
10.1002/cncr.29874

Functional screen identifies kinases driving prostate cancer visceral and bone metastasis

Authors
Faltermeier, CM; Drake, JM; Clark, PM; Smith, BA; Zong, Y; Volpe, C; Mathis, C; Morrissey, C; Castor, B; Huang, J; Witte, ON
MLA Citation
Faltermeier, CM, Drake, JM, Clark, PM, Smith, BA, Zong, Y, Volpe, C, Mathis, C, Morrissey, C, Castor, B, Huang, J, and Witte, ON. "Functional screen identifies kinases driving prostate cancer visceral and bone metastasis." Proceedings of the National Academy of Sciences 113.2 (January 12, 2016): E172-E181.
Source
crossref
Published In
Proceedings of the National Academy of Sciences of USA
Volume
113
Issue
2
Publish Date
2016
Start Page
E172
End Page
E181
DOI
10.1073/pnas.1521674112

Collecting Duct Carcinoma and Renal Medullary Carcinoma

Authors
Koo, J; Filson, CP; Huang, J; Pantuck, AJ
MLA Citation
Koo, J, Filson, CP, Huang, J, and Pantuck, AJ. "Collecting Duct Carcinoma and Renal Medullary Carcinoma." The Kidney: A Comprehensive Guide to Pathologic Diagnosis and Management. Ed. DE Hansel, CJ Kane, GP Paner, and S Chang. 2016. 109-123. (Chapter)
Source
manual
Publish Date
2016
Start Page
109
End Page
123

Multiparametric magnetic resonance imaging for prostate cancer improves Gleason score assessment in favorable risk prostate cancer

Authors
Kamrava, M; Kishan, AU; Margolis, DJ; Huang, J; Dorey, F; Lieu, P; Kupelian, PA; Marks, LS
MLA Citation
Kamrava, M, Kishan, AU, Margolis, DJ, Huang, J, Dorey, F, Lieu, P, Kupelian, PA, and Marks, LS. "Multiparametric magnetic resonance imaging for prostate cancer improves Gleason score assessment in favorable risk prostate cancer." Practical Radiation Oncology 5.6 (November 2015): 411-416.
Source
crossref
Published In
Practical Radiation Oncology
Volume
5
Issue
6
Publish Date
2015
Start Page
411
End Page
416
DOI
10.1016/j.prro.2015.04.006

Prostate diffusion imaging with distortion correction

Authors
Rakow-Penner, RA; White, NS; Margolis, DJA; Parsons, JK; Schenker-Ahmed, N; Kuperman, JM; Bartsch, H; Choi, HW; Bradley, WG; Shabaik, A; Huang, J; Liss, MA; Marks, L; Kane, CJ; Reiter, RE; Raman, SS; Karow, DS; Dale, AM
MLA Citation
Rakow-Penner, RA, White, NS, Margolis, DJA, Parsons, JK, Schenker-Ahmed, N, Kuperman, JM, Bartsch, H, Choi, HW, Bradley, WG, Shabaik, A, Huang, J, Liss, MA, Marks, L, Kane, CJ, Reiter, RE, Raman, SS, Karow, DS, and Dale, AM. "Prostate diffusion imaging with distortion correction." Magnetic Resonance Imaging 33.9 (November 2015): 1178-1181.
Source
crossref
Published In
Magnetic Resonance Imaging
Volume
33
Issue
9
Publish Date
2015
Start Page
1178
End Page
1181
DOI
10.1016/j.mri.2015.07.006

Exploring Glycan Markers for Immunotyping and Precision-targeting of Breast Circulating Tumor Cells

Authors
Wang, D; Liu, X; Hsieh, B; Bruce, R; Somlo, G; Huang, J; Sambucetti, L
MLA Citation
Wang, D, Liu, X, Hsieh, B, Bruce, R, Somlo, G, Huang, J, and Sambucetti, L. "Exploring Glycan Markers for Immunotyping and Precision-targeting of Breast Circulating Tumor Cells." Archives of Medical Research 46.8 (November 2015): 642-650.
Source
crossref
Published In
Archives of Medical Research
Volume
46
Issue
8
Publish Date
2015
Start Page
642
End Page
650
DOI
10.1016/j.arcmed.2015.11.007

Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer

Authors
Chen, Z; Lan, X; Wu, D; Sunkel, B; Ye, Z; Huang, J; Liu, Z; Clinton, SK; Jin, VX; Wang, Q
MLA Citation
Chen, Z, Lan, X, Wu, D, Sunkel, B, Ye, Z, Huang, J, Liu, Z, Clinton, SK, Jin, VX, and Wang, Q. "Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer." Nature Communications 6 (September 16, 2015): 8323-8323.
Source
crossref
Published In
Nature Communications
Volume
6
Publish Date
2015
Start Page
8323
End Page
8323
DOI
10.1038/ncomms9323

Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral metastases

Authors
Chen, J-F; Ho, H; Lichterman, J; Lu, Y-T; Zhang, Y; Garcia, MA; Chen, S-F; Liang, A-J; Hodara, E; Zhau, HE; Hou, S; Ahmed, RS; Luthringer, DJ; Huang, J; Li, K-C; Chung, LWK; Ke, Z; Tseng, H-R; Posadas, EM
MLA Citation
Chen, J-F, Ho, H, Lichterman, J, Lu, Y-T, Zhang, Y, Garcia, MA, Chen, S-F, Liang, A-J, Hodara, E, Zhau, HE, Hou, S, Ahmed, RS, Luthringer, DJ, Huang, J, Li, K-C, Chung, LWK, Ke, Z, Tseng, H-R, and Posadas, EM. "Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral metastases." Cancer 121.18 (September 15, 2015): 3240-3251.
Source
crossref
Published In
Cancer
Volume
121
Issue
18
Publish Date
2015
Start Page
3240
End Page
3251
DOI
10.1002/cncr.29455

Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells

Authors
Liu, X; Chen, X; Rycaj, K; Chao, H-P; Deng, Q; Jeter, C; Liu, C; Honorio, S; Li, H; Davis, T; Suraneni, M; Laffin, B; Qin, J; Li, Q; Yang, T; Whitney, P; Shen, J; Huang, J; Tang, DG
MLA Citation
Liu, X, Chen, X, Rycaj, K, Chao, H-P, Deng, Q, Jeter, C, Liu, C, Honorio, S, Li, H, Davis, T, Suraneni, M, Laffin, B, Qin, J, Li, Q, Yang, T, Whitney, P, Shen, J, Huang, J, and Tang, DG. "Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells." Oncotarget 6.27 (September 2, 2015): 23959-23986.
Source
crossref
Published In
Oncotarget
Volume
6
Issue
27
Publish Date
2015
Start Page
23959
End Page
23986
DOI
10.18632/oncotarget.4260

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression

Authors
Gan, W; Dai, X; Lunardi, A; Li, Z; Inuzuka, H; Liu, P; Varmeh, S; Zhang, J; Cheng, L; Sun, Y; Asara, JM; Beck, AH; Huang, J; Pandolfi, PP; Wei, W
MLA Citation
Gan, W, Dai, X, Lunardi, A, Li, Z, Inuzuka, H, Liu, P, Varmeh, S, Zhang, J, Cheng, L, Sun, Y, Asara, JM, Beck, AH, Huang, J, Pandolfi, PP, and Wei, W. "SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression." Molecular Cell 59.6 (September 2015): 917-930.
Source
crossref
Published In
Molecular Cell
Volume
59
Issue
6
Publish Date
2015
Start Page
917
End Page
930
DOI
10.1016/j.molcel.2015.07.026

Functional expression of sodium-glucose transporters in cancer

Authors
Scafoglio, C; Hirayama, BA; Kepe, V; Liu, J; Ghezzi, C; Satyamurthy, N; Moatamed, NA; Huang, J; Koepsell, H; Barrio, JR; Wright, EM
MLA Citation
Scafoglio, C, Hirayama, BA, Kepe, V, Liu, J, Ghezzi, C, Satyamurthy, N, Moatamed, NA, Huang, J, Koepsell, H, Barrio, JR, and Wright, EM. "Functional expression of sodium-glucose transporters in cancer." Proceedings of the National Academy of Sciences 112.30 (July 28, 2015): E4111-E4119.
Source
crossref
Published In
Proceedings of the National Academy of Sciences of USA
Volume
112
Issue
30
Publish Date
2015
Start Page
E4111
End Page
E4119
DOI
10.1073/pnas.1511698112

Patients with Biopsy Gleason 9 and 10 Prostate Cancer Have Significantly Worse Outcomes Compared to Patients with Gleason 8 Disease

Authors
Tsao, C-K; Gray, KP; Nakabayashi, M; Evan, C; Kantoff, PW; Huang, J; Galsky, MD; Pomerantz, M; Oh, WK
MLA Citation
Tsao, C-K, Gray, KP, Nakabayashi, M, Evan, C, Kantoff, PW, Huang, J, Galsky, MD, Pomerantz, M, and Oh, WK. "Patients with Biopsy Gleason 9 and 10 Prostate Cancer Have Significantly Worse Outcomes Compared to Patients with Gleason 8 Disease." The Journal of Urology 194.1 (July 2015): 91-97.
Source
crossref
Published In
The Journal of Urology
Volume
194
Issue
1
Publish Date
2015
Start Page
91
End Page
97
DOI
10.1016/j.juro.2015.01.078

Neuroendocrine Differentiation in Prostate Cancer: A Mechanism of Radioresistance and Treatment Failure

Authors
Hu, C-D; Choo, R; Huang, J
MLA Citation
Hu, C-D, Choo, R, and Huang, J. "Neuroendocrine Differentiation in Prostate Cancer: A Mechanism of Radioresistance and Treatment Failure." Frontiers in Oncology 5 (April 14, 2015).
Source
crossref
Published In
Frontiers in Oncology
Volume
5
Publish Date
2015
DOI
10.3389/fonc.2015.00090

Loss of MyD88 leads to more aggressive TRAMP prostate cancer and influences tumor infiltrating lymphocytes

Authors
Peek, EM; Song, W; Zhang, H; Huang, J; Chin, AI
MLA Citation
Peek, EM, Song, W, Zhang, H, Huang, J, and Chin, AI. "Loss of MyD88 leads to more aggressive TRAMP prostate cancer and influences tumor infiltrating lymphocytes." The Prostate 75.5 (April 2015): 463-473.
Source
crossref
Published In
The Prostate
Volume
75
Issue
5
Publish Date
2015
Start Page
463
End Page
473
DOI
10.1002/pros.22932

CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

Authors
Escamilla, J; Schokrpur, S; Liu, C; Priceman, SJ; Moughon, D; Jiang, Z; Pouliot, F; Magyar, C; Sung, JL; Xu, J; Deng, G; West, BL; Bollag, G; Fradet, Y; Lacombe, L; Jung, ME; Huang, J; Wu, L
MLA Citation
Escamilla, J, Schokrpur, S, Liu, C, Priceman, SJ, Moughon, D, Jiang, Z, Pouliot, F, Magyar, C, Sung, JL, Xu, J, Deng, G, West, BL, Bollag, G, Fradet, Y, Lacombe, L, Jung, ME, Huang, J, and Wu, L. "CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy." Cancer Research 75.6 (March 15, 2015): 950-962.
Source
crossref
Published In
Cancer Research
Volume
75
Issue
6
Publish Date
2015
Start Page
950
End Page
962
DOI
10.1158/0008-5472.CAN-14-0992

p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma

Authors
Li, Z; Sun, Y; Chen, X; Squires, J; Nowroozizadeh, B; Liang, C; Huang, J
MLA Citation
Li, Z, Sun, Y, Chen, X, Squires, J, Nowroozizadeh, B, Liang, C, and Huang, J. "p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma." Molecular Cancer Research 13.3 (March 1, 2015): 584-591.
Source
crossref
Published In
Molecular cancer research : MCR
Volume
13
Issue
3
Publish Date
2015
Start Page
584
End Page
591
DOI
10.1158/1541-7786.MCR-14-0277-T

Multifocality and Prostate Cancer Detection by Multiparametric Magnetic Resonance Imaging: Correlation with Whole-mount Histopathology

Authors
Le, JD; Tan, N; Shkolyar, E; Lu, DY; Kwan, L; Marks, LS; Huang, J; Margolis, DJA; Raman, SS; Reiter, RE
MLA Citation
Le, JD, Tan, N, Shkolyar, E, Lu, DY, Kwan, L, Marks, LS, Huang, J, Margolis, DJA, Raman, SS, and Reiter, RE. "Multifocality and Prostate Cancer Detection by Multiparametric Magnetic Resonance Imaging: Correlation with Whole-mount Histopathology." European Urology 67.3 (March 2015): 569-576.
Source
crossref
Published In
European Urology
Volume
67
Issue
3
Publish Date
2015
Start Page
569
End Page
576
DOI
10.1016/j.eururo.2014.08.079

MRI-Derived Restriction Spectrum Imaging Cellularity Index is Associated with High Grade Prostate Cancer on Radical Prostatectomy Specimens

Authors
Liss, MA; White, NS; Parsons, JK; Schenker-Ahmed, NM; Rakow-Penner, R; Kuperman, JM; Bartsch, H; Choi, HW; Mattrey, RF; Bradley, WG; Shabaik, A; Huang, J; Margolis, DJA; Raman, SS; Marks, LS; Kane, CJ; Reiter, RE; Dale, AM; Karow, DS
MLA Citation
Liss, MA, White, NS, Parsons, JK, Schenker-Ahmed, NM, Rakow-Penner, R, Kuperman, JM, Bartsch, H, Choi, HW, Mattrey, RF, Bradley, WG, Shabaik, A, Huang, J, Margolis, DJA, Raman, SS, Marks, LS, Kane, CJ, Reiter, RE, Dale, AM, and Karow, DS. "MRI-Derived Restriction Spectrum Imaging Cellularity Index is Associated with High Grade Prostate Cancer on Radical Prostatectomy Specimens." Frontiers in Oncology 5 (February 17, 2015).
Source
crossref
Published In
Frontiers in Oncology
Volume
5
Publish Date
2015
DOI
10.3389/fonc.2015.00030

Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer

Authors
Chen, Z; Lan, X; Thomas-Ahner, JM; Wu, D; Liu, X; Ye, Z; Wang, L; Sunkel, B; Grenade, C; Chen, J; Zynger, DL; Yan, PS; Huang, J; Nephew, KP; Huang, TH-M; Lin, S; Clinton, SK; Li, W; Jin, VX; Wang, Q
MLA Citation
Chen, Z, Lan, X, Thomas-Ahner, JM, Wu, D, Liu, X, Ye, Z, Wang, L, Sunkel, B, Grenade, C, Chen, J, Zynger, DL, Yan, PS, Huang, J, Nephew, KP, Huang, TH-M, Lin, S, Clinton, SK, Li, W, Jin, VX, and Wang, Q. "Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer." The EMBO Journal 34.4 (February 12, 2015): 502-516.
Source
crossref
Published In
EMBO Journal
Volume
34
Issue
4
Publish Date
2015
Start Page
502
End Page
516
DOI
10.15252/embj.201490306

Elevated circulating tissue inhibitor of metalloproteinase 1 (TIMP-1) levels are associated with neuroendocrine differentiation in castration resistant prostate cancer

Authors
Gong, Y; Chippada-Venkata, UD; Galsky, MD; Huang, J; Oh, MK
MLA Citation
Gong, Y, Chippada-Venkata, UD, Galsky, MD, Huang, J, and Oh, MK. "Elevated circulating tissue inhibitor of metalloproteinase 1 (TIMP-1) levels are associated with neuroendocrine differentiation in castration resistant prostate cancer." Prostate 75.6 (2015): 616-627.
Source
manual
Published In
Prostate
Volume
75
Issue
6
Publish Date
2015
Start Page
616
End Page
627

Redefining the Autonomic Nerve Distribution of the Urinary Bladder Using Three-Dimensional Image Reconstruction

Authors
Spradling, K; Khoyilar, C; Abedi, G; Okhumov, Z; Wikenheiser, J; Yoon, R; Huang, J; Youssef, RF; Ghoniem, G; Landman, J
MLA Citation
Spradling, K, Khoyilar, C, Abedi, G, Okhumov, Z, Wikenheiser, J, Yoon, R, Huang, J, Youssef, RF, Ghoniem, G, and Landman, J. "Redefining the Autonomic Nerve Distribution of the Urinary Bladder Using Three-Dimensional Image Reconstruction." Journal of Urology 194.6 (2015): 1661-1667.
Source
manual
Published In
Journal of Urology
Volume
194
Issue
6
Publish Date
2015
Start Page
1661
End Page
1667

EGF receptor promotes prostate cancer bone metastasis by downregulating miR-1 and activating TWIST1

Authors
Chang, YS; Chen, WY; Yin, JJ; Tillman, H; Huang, J; Liu, YN
MLA Citation
Chang, YS, Chen, WY, Yin, JJ, Tillman, H, Huang, J, and Liu, YN. "EGF receptor promotes prostate cancer bone metastasis by downregulating miR-1 and activating TWIST1." Cancer Research 75.15 (2015): 3077-3086.
Source
manual
Published In
Cancer Research
Volume
75
Issue
15
Publish Date
2015
Start Page
3077
End Page
3086

Characteristics of Detected and Missed Prostate Cancer Foci on 3-T Multiparametric MRI Using an Endorectal Coil Correlated With Whole-Mount Thin-Section Histopathology

Authors
Tan, N; Margolis, DJ; Lu, DY; King, KG; Huang, J; Reiter, RE; Raman, SS
MLA Citation
Tan, N, Margolis, DJ, Lu, DY, King, KG, Huang, J, Reiter, RE, and Raman, SS. "Characteristics of Detected and Missed Prostate Cancer Foci on 3-T Multiparametric MRI Using an Endorectal Coil Correlated With Whole-Mount Thin-Section Histopathology." AJR. American journal of roentgenology 205.1 (2015): W87-W92.
Source
manual
Published In
AJR. American journal of roentgenology
Volume
205
Issue
1
Publish Date
2015
Start Page
W87
End Page
W92

Carbohydrate Microarrays Identify Blood Group Precursor Cryptic Epitopes as Potential Immunological Targets of Breast Cancer

Authors
Wang, D; Tang, J; Liu, S; Huang, J
MLA Citation
Wang, D, Tang, J, Liu, S, and Huang, J. "Carbohydrate Microarrays Identify Blood Group Precursor Cryptic Epitopes as Potential Immunological Targets of Breast Cancer." Journal of Immunology Research 2015 (2015): 1-9.
Source
crossref
Published In
Journal of Immunology Research
Volume
2015
Publish Date
2015
Start Page
1
End Page
9
DOI
10.1155/2015/510810

Serial MRI in Active Surveillance of Prostate Cancer: Incremental Value

Authors
Felker, ER; Wu, J; Natarajan, S; Margolis, DJ; Raman, SS; Huang, J; Dorey, F; Marks, LS
MLA Citation
Felker, ER, Wu, J, Natarajan, S, Margolis, DJ, Raman, SS, Huang, J, Dorey, F, and Marks, LS. "Serial MRI in Active Surveillance of Prostate Cancer: Incremental Value." The Journal of Urology 195.5 (2015): 1421-1427.
Source
manual
Published In
The Journal of Urology
Volume
195
Issue
5
Publish Date
2015
Start Page
1421
End Page
1427

Initial experience with electronic tracking of specific tumor sites in men undergoing active surveillance of prostate cancer

Authors
Sonn, GA; Filson, CP; Chang, E; Natarajan, S; Margolis, DJ; Macairan, M; Lieu, P; Huang, J; Dorey, FJ; Reiter, RE; Marks, LS
MLA Citation
Sonn, GA, Filson, CP, Chang, E, Natarajan, S, Margolis, DJ, Macairan, M, Lieu, P, Huang, J, Dorey, FJ, Reiter, RE, and Marks, LS. "Initial experience with electronic tracking of specific tumor sites in men undergoing active surveillance of prostate cancer." Urologic Oncology: Seminars and Original Investigations 32.7 (October 2014): 952-957.
Source
crossref
Published In
Urologic Oncology: Seminars and Original Investigations
Volume
32
Issue
7
Publish Date
2014
Start Page
952
End Page
957
DOI
10.1016/j.urolonc.2014.04.003

Targeted Prostate Biopsy to Select Men for Active Surveillance: Do the Epstein Criteria Still Apply?

Authors
Hu, JC; Chang, E; Natarajan, S; Margolis, DJ; Macairan, M; Lieu, P; Huang, J; Sonn, G; Dorey, FJ; Marks, LS
MLA Citation
Hu, JC, Chang, E, Natarajan, S, Margolis, DJ, Macairan, M, Lieu, P, Huang, J, Sonn, G, Dorey, FJ, and Marks, LS. "Targeted Prostate Biopsy to Select Men for Active Surveillance: Do the Epstein Criteria Still Apply?." The Journal of Urology 192.2 (August 2014): 385-390.
Source
crossref
Published In
The Journal of Urology
Volume
192
Issue
2
Publish Date
2014
Start Page
385
End Page
390
DOI
10.1016/j.juro.2014.02.005

Aggressive Variants of Castration-Resistant Prostate Cancer

Authors
Beltran, H; Tomlins, S; Aparicio, A; Arora, V; Rickman, D; Ayala, G; Huang, J; True, L; Gleave, ME; Soule, H; Logothetis, C; Rubin, MA
MLA Citation
Beltran, H, Tomlins, S, Aparicio, A, Arora, V, Rickman, D, Ayala, G, Huang, J, True, L, Gleave, ME, Soule, H, Logothetis, C, and Rubin, MA. "Aggressive Variants of Castration-Resistant Prostate Cancer." Clinical Cancer Research 20.11 (June 1, 2014): 2846-2850.
Source
crossref
Published In
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume
20
Issue
11
Publish Date
2014
Start Page
2846
End Page
2850
DOI
10.1158/1078-0432.CCR-13-3309

Value of Targeted Prostate Biopsy Using Magnetic Resonance–Ultrasound Fusion in Men with Prior Negative Biopsy and Elevated Prostate-specific Antigen

Authors
Sonn, GA; Chang, E; Natarajan, S; Margolis, DJ; Macairan, M; Lieu, P; Huang, J; Dorey, FJ; Reiter, RE; Marks, LS
MLA Citation
Sonn, GA, Chang, E, Natarajan, S, Margolis, DJ, Macairan, M, Lieu, P, Huang, J, Dorey, FJ, Reiter, RE, and Marks, LS. "Value of Targeted Prostate Biopsy Using Magnetic Resonance–Ultrasound Fusion in Men with Prior Negative Biopsy and Elevated Prostate-specific Antigen." European Urology 65.4 (April 2014): 809-815.
Source
crossref
Published In
European Urology
Volume
65
Issue
4
Publish Date
2014
Start Page
809
End Page
815
DOI
10.1016/j.eururo.2013.03.025

Intrarenal and Extrarenal Autonomic Nervous System Redefined

Authors
Lusch, A; Leary, R; Heidari, E; Liss, MA; Okhunov, Z; Perez-Lanzac De Lorca, A; Huang, J; Wikenheiser, J; Landman, J
MLA Citation
Lusch, A, Leary, R, Heidari, E, Liss, MA, Okhunov, Z, Perez-Lanzac De Lorca, A, Huang, J, Wikenheiser, J, and Landman, J. "Intrarenal and Extrarenal Autonomic Nervous System Redefined." The Journal of Urology 191.4 (April 2014): 1060-1065.
Source
crossref
Published In
The Journal of Urology
Volume
191
Issue
4
Publish Date
2014
Start Page
1060
End Page
1065
DOI
10.1016/j.juro.2013.11.108

Androgen Receptor Splice Variant AR3 Promotes Prostate Cancer via Modulating Expression of Autocrine/Paracrine Factors

Authors
Sun, F; Chen, H-G; Li, W; Yang, X; Wang, X; Jiang, R; Guo, Z; Chen, H; Huang, J; Borowsky, AD; Qiu, Y
MLA Citation
Sun, F, Chen, H-G, Li, W, Yang, X, Wang, X, Jiang, R, Guo, Z, Chen, H, Huang, J, Borowsky, AD, and Qiu, Y. "Androgen Receptor Splice Variant AR3 Promotes Prostate Cancer via Modulating Expression of Autocrine/Paracrine Factors." Journal of Biological Chemistry 289.3 (January 17, 2014): 1529-1539.
Source
crossref
Published In
The Journal of biological chemistry
Volume
289
Issue
3
Publish Date
2014
Start Page
1529
End Page
1539
DOI
10.1074/jbc.M113.492140

Erk/MAP Kinase Signaling Pathway and Neuroendocrine Differentiation of Non–Small-Cell Lung Cancer

Authors
Chen, Y; Nowak, I; Huang, J; Keng, PC; Sun, H; Xu, H; Wei, G; Lee, SO
MLA Citation
Chen, Y, Nowak, I, Huang, J, Keng, PC, Sun, H, Xu, H, Wei, G, and Lee, SO. "Erk/MAP Kinase Signaling Pathway and Neuroendocrine Differentiation of Non–Small-Cell Lung Cancer." Journal of Thoracic Oncology 9.1 (January 2014): 50-58.
Source
crossref
Published In
Journal of Thoracic Oncology
Volume
9
Issue
1
Publish Date
2014
Start Page
50
End Page
58
DOI
10.1097/JTO.0000000000000034

Targeted prostate biopsy: Value of multi-parametric magnetic resonance imaging in detection of localized cancer

Authors
Le, JD; Huang, J; Marks, LS
MLA Citation
Le, JD, Huang, J, and Marks, LS. "Targeted prostate biopsy: Value of multi-parametric magnetic resonance imaging in detection of localized cancer." Asian journal of andrology 16.4 (2014): 522-529.
Source
manual
Published In
Asian journal of andrology
Volume
16
Issue
4
Publish Date
2014
Start Page
522
End Page
529

RE. The role of magnetic resonance imaging in delineating clinically significant prostate cancer

Authors
Chamie, K; Soon, GA; Finley, DS; Tan, N; Margolis, DJ; Raman, SS; Natarajan, S; Huang, J; Reiter, RE
MLA Citation
Chamie, K, Soon, GA, Finley, DS, Tan, N, Margolis, DJ, Raman, SS, Natarajan, S, Huang, J, and Reiter, RE. "RE. The role of magnetic resonance imaging in delineating clinically significant prostate cancer." Urology 83.2 (2014): 369-375.
Source
manual
Published In
Urology
Volume
83
Issue
2
Publish Date
2014
Start Page
369
End Page
375

Poor prognosis and advanced clinicopathological features of clear cell renal cell carcinoma (ccRCC) are associated with cytoplasmic subcellular localisation of Hypoxia inducible factor-2α

Authors
Kroeger, N; Seligson, DB; Signoretti, S; Yu, H; Magyar, CE; Huang, J; Beldegrum, AS; Pantuck, AJ
MLA Citation
Kroeger, N, Seligson, DB, Signoretti, S, Yu, H, Magyar, CE, Huang, J, Beldegrum, AS, and Pantuck, AJ. "Poor prognosis and advanced clinicopathological features of clear cell renal cell carcinoma (ccRCC) are associated with cytoplasmic subcellular localisation of Hypoxia inducible factor-2α." European journal of cancer 50.8 (2014): 1531-1540.
Source
manual
Published In
European journal of cancer
Volume
50
Issue
8
Publish Date
2014
Start Page
1531
End Page
1540

Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation

Authors
Huang, J; Lipianskaya, J; Cohen, A; Hsia, E; Squires, J; Li, Z; Zhang, Y; Li, W; Xu, H; Chen, C; Chen, X
MLA Citation
Huang, J, Lipianskaya, J, Cohen, A, Hsia, E, Squires, J, Li, Z, Zhang, Y, Li, W, Xu, H, Chen, C, and Chen, X. "Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation." Asian Journal of Andrology 16.4 (2014): 541-541.
Source
crossref
Published In
Asian journal of andrology
Volume
16
Issue
4
Publish Date
2014
Start Page
541
End Page
541
DOI
10.4103/1008-682X.123669

Increased androgen receptor gene copy number is associated with TMPRSS2-ERG rearrangement in prostatic small cell carcinoma

Authors
Wang, L; Williamson, SR; Zhang, S; Huang, J; Montironi, R; Davison, DD; Wang, M; Yao, JL; Lopez-Beltran, A; Osunkoya, AO; Maclennan, GT; Baldridge, LA; Du, X; Cheng, L
MLA Citation
Wang, L, Williamson, SR, Zhang, S, Huang, J, Montironi, R, Davison, DD, Wang, M, Yao, JL, Lopez-Beltran, A, Osunkoya, AO, Maclennan, GT, Baldridge, LA, Du, X, and Cheng, L. "Increased androgen receptor gene copy number is associated with TMPRSS2-ERG rearrangement in prostatic small cell carcinoma." Molecular Carcinogenesis 54.9 (2014): 900-907.
Source
manual
Published In
Molecular Carcinogenesis
Volume
54
Issue
9
Publish Date
2014
Start Page
900
End Page
907

Magnetic resonance imaging-ultrasound fusion biopsy for prediction of final prostate pathology

Authors
Le, JD; Stephenson, S; Brugger, M; Lu, DY; Lieu, P; Sonn, GA; Natarajan, S; Dorey, FJ; Huang, J; Margolis, DJ; Reiter, RE; Marks, LS
MLA Citation
Le, JD, Stephenson, S, Brugger, M, Lu, DY, Lieu, P, Sonn, GA, Natarajan, S, Dorey, FJ, Huang, J, Margolis, DJ, Reiter, RE, and Marks, LS. "Magnetic resonance imaging-ultrasound fusion biopsy for prediction of final prostate pathology." Journal of Urology 192.5 (2014): 1367-1373.
Source
manual
Published In
Journal of Urology
Volume
192
Issue
5
Publish Date
2014
Start Page
1367
End Page
1373

RARP in high-risk prostate cancer: use of multi-parametric MRI and nerve sparing techniques

Authors
Chin, A; Huang, J; Wang, J-G
MLA Citation
Chin, A, Huang, J, and Wang, J-G. "RARP in high-risk prostate cancer: use of multi-parametric MRI and nerve sparing techniques." Asian Journal of Andrology 16.5 (2014): 715-715.
Source
crossref
Published In
Asian journal of andrology
Volume
16
Issue
5
Publish Date
2014
Start Page
715
End Page
715
DOI
10.4103/1008-682X.129942

Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance

Authors
Siu, MK; Abou-Kheir, W; Yin, JJ; Chang, YS; Barrett, B; Suau, F; Casey, O; Chen, WY; Fang, L; Hynes, P; Hsieh, YY; Liu, YN; Huang, J; Kelly, K
MLA Citation
Siu, MK, Abou-Kheir, W, Yin, JJ, Chang, YS, Barrett, B, Suau, F, Casey, O, Chen, WY, Fang, L, Hynes, P, Hsieh, YY, Liu, YN, Huang, J, and Kelly, K. "Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance." Oncotarget 5.11 (2014): 3770-3784.
Source
manual
Published In
Oncotarget
Volume
5
Issue
11
Publish Date
2014
Start Page
3770
End Page
3784

A system for evaluating magnetic resonance imaging of prostate cancer using patient-specific 3D printed molds

Authors
Priester, A; Natarajan, S; Le, JD; Garritano, J; Radosavcev, B; Grundfest, W; Margolis, DJA; Marks, LS; Huang, J
MLA Citation
Priester, A, Natarajan, S, Le, JD, Garritano, J, Radosavcev, B, Grundfest, W, Margolis, DJA, Marks, LS, and Huang, J. "A system for evaluating magnetic resonance imaging of prostate cancer using patient-specific 3D printed molds." American journal of clinical and experimental urology 2 (2014): 127-135.
Source
manual
Published In
American journal of clinical and experimental urology
Volume
2
Publish Date
2014
Start Page
127
End Page
135

PIP5K1α inhibition as a therapeutic strategy for prostate cancer

Authors
Drake, JM; Huang, J
MLA Citation
Drake, JM, and Huang, J. "PIP5K1α inhibition as a therapeutic strategy for prostate cancer." Proceedings of the National Academy of Sciences of USA 111.35 (2014): 12578-12579.
Source
manual
Published In
Proceedings of the National Academy of Sciences of USA
Volume
111
Issue
35
Publish Date
2014
Start Page
12578
End Page
12579

PIP5K1α inhibition as a therapeutic strategy for prostate cancer

Authors
Drake, JM; Huang, J
MLA Citation
Drake, JM, and Huang, J. "PIP5K1α inhibition as a therapeutic strategy for prostate cancer." Proceedings of the National Academy of Sciences of USA (2014).
Source
manual
Published In
Proceedings of the National Academy of Sciences of USA
Publish Date
2014

Fasting times in serum PSA assay

Authors
Huang, J; Xu, X; Lipianskaya, J
MLA Citation
Huang, J, Xu, X, and Lipianskaya, J. "Fasting times in serum PSA assay." Asian Journal of Andrology 16.5 (2014): 786-786.
Source
crossref
Published In
Asian journal of andrology
Volume
16
Issue
5
Publish Date
2014
Start Page
786
End Page
786
DOI
10.4103/1008-682X.125405

Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells.

The relationship between the cells that initiate cancer and the cancer stem-like cells that propagate tumors has been poorly defined. In a human prostate tissue transformation model, basal cells expressing the oncogenes Myc and myristoylated AKT can initiate heterogeneous tumors. Tumors contain features of acinar-type adenocarcinoma with elevated eIF4E-driven protein translation and squamous cell carcinoma marked by activated beta-catenin. Lentiviral integration site analysis revealed that alternative histological phenotypes can be clonally derived from a common cell of origin. In advanced disease, adenocarcinoma can be propagated by self-renewing tumor cells with an androgen receptor-low immature luminal phenotype in the absence of basal-like cells. These data indicate that advanced prostate adenocarcinoma initiated in basal cells can be maintained by luminal-like tumor-propagating cells. Determining the cells that maintain human prostate adenocarcinoma and the signaling pathways characterizing these tumor-propagating cells is critical for developing effective therapeutic strategies against this population.

Authors
Stoyanova, T; Cooper, AR; Drake, JM; Liu, X; Armstrong, AJ; Pienta, KJ; Zhang, H; Kohn, DB; Huang, J; Witte, ON; Goldstein, AS
MLA Citation
Stoyanova, T, Cooper, AR, Drake, JM, Liu, X, Armstrong, AJ, Pienta, KJ, Zhang, H, Kohn, DB, Huang, J, Witte, ON, and Goldstein, AS. "Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells." Proceedings of the National Academy of Sciences of the United States of America 110.50 (December 2013): 20111-20116.
PMID
24282295
Source
epmc
Published In
Proceedings of the National Academy of Sciences of USA
Volume
110
Issue
50
Publish Date
2013
Start Page
20111
End Page
20116
DOI
10.1073/pnas.1320565110

NanoVelcro Chip for CTC enumeration in prostate cancer patients

Authors
Lu, Y-T; Zhao, L; Shen, Q; Garcia, MA; Wu, D; Hou, S; Song, M; Xu, X; OuYang, W-H; OuYang, WW-L; Lichterman, J; Luo, Z; Xuan, X; Huang, J; Chung, LWK; Rettig, M; Tseng, H-R; Shao, C; Posadas, EM
MLA Citation
Lu, Y-T, Zhao, L, Shen, Q, Garcia, MA, Wu, D, Hou, S, Song, M, Xu, X, OuYang, W-H, OuYang, WW-L, Lichterman, J, Luo, Z, Xuan, X, Huang, J, Chung, LWK, Rettig, M, Tseng, H-R, Shao, C, and Posadas, EM. "NanoVelcro Chip for CTC enumeration in prostate cancer patients." Methods 64.2 (December 2013): 144-152.
Source
crossref
Published In
Methods
Volume
64
Issue
2
Publish Date
2013
Start Page
144
End Page
152
DOI
10.1016/j.ymeth.2013.06.019

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Authors
Srigley, JR; Delahunt, B; Eble, JN; Egevad, L; Epstein, JI; Grignon, D; Hes, O; Moch, H; Montironi, R; Tickoo, SK; Zhou, M; Argani, P; ISUP Renal Tumor Panel,
MLA Citation
Srigley, JR, Delahunt, B, Eble, JN, Egevad, L, Epstein, JI, Grignon, D, Hes, O, Moch, H, Montironi, R, Tickoo, SK, Zhou, M, Argani, P, and ISUP Renal Tumor Panel, . "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia." The American Journal of Surgical Pathology 37.10 (October 2013): 1469-1489.
Source
manual
Published In
American Journal of Surgical Pathology
Volume
37
Issue
10
Publish Date
2013
Start Page
1469
End Page
1489
DOI
10.1097/PAS.0b013e318299f2d1

The International Society of Urological Pathology (ISUP) Grading System for Renal Cell Carcinoma and Other Prognostic Parameters

Authors
Delahunt, B; Cheville, JC; Martignoni, G; Humphrey, PA; Magi-Galluzzi, C; McKenney, J; Egevad, L; Algaba, F; Moch, H; Grignon, DJ; Montironi, R; Srigley, JR; Members of the ISUP Renal Tumor Panel,
MLA Citation
Delahunt, B, Cheville, JC, Martignoni, G, Humphrey, PA, Magi-Galluzzi, C, McKenney, J, Egevad, L, Algaba, F, Moch, H, Grignon, DJ, Montironi, R, Srigley, JR, and Members of the ISUP Renal Tumor Panel, . "The International Society of Urological Pathology (ISUP) Grading System for Renal Cell Carcinoma and Other Prognostic Parameters." The American Journal of Surgical Pathology 37.10 (October 2013): 1490-1504.
Source
manual
Published In
American Journal of Surgical Pathology
Volume
37
Issue
10
Publish Date
2013
Start Page
1490
End Page
1504
DOI
10.1097/PAS.0b013e318299f0fb

Enrichment of putative prostate cancer stem cells after androgen deprivation: Upregulation of pluripotency transactivators concurs with resistance to androgen deprivation in LNCaP cell lines

Authors
Seiler, D; Zheng, J; Liu, G; Wang, S; Yamashiro, J; Reiter, RE; Huang, J; Zeng, G
MLA Citation
Seiler, D, Zheng, J, Liu, G, Wang, S, Yamashiro, J, Reiter, RE, Huang, J, and Zeng, G. "Enrichment of putative prostate cancer stem cells after androgen deprivation: Upregulation of pluripotency transactivators concurs with resistance to androgen deprivation in LNCaP cell lines." The Prostate 73.13 (September 2013): 1378-1390.
Source
crossref
Published In
The Prostate
Volume
73
Issue
13
Publish Date
2013
Start Page
1378
End Page
1390
DOI
10.1002/pros.22685

Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer

Authors
Ren, S; Wang, F; Shen, J; Sun, Y; Xu, W; Lu, J; Wei, M; Xu, C; Wu, C; Zhang, Z; Gao, X; Liu, Z; Hou, J; Huang, J; Sun, Y
MLA Citation
Ren, S, Wang, F, Shen, J, Sun, Y, Xu, W, Lu, J, Wei, M, Xu, C, Wu, C, Zhang, Z, Gao, X, Liu, Z, Hou, J, Huang, J, and Sun, Y. "Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer." European Journal of Cancer 49.13 (September 2013): 2949-2959.
Source
crossref
Published In
European Journal of Cancer
Volume
49
Issue
13
Publish Date
2013
Start Page
2949
End Page
2959
DOI
10.1016/j.ejca.2013.04.026

The molecular basis for ethnic variation and histological subtype differences in prostate cancer

Authors
Zong, Y; Goldstein, AS; Huang, J
MLA Citation
Zong, Y, Goldstein, AS, and Huang, J. "The molecular basis for ethnic variation and histological subtype differences in prostate cancer." Science China Life Sciences 56.9 (September 2013): 780-787.
Source
crossref
Published In
Science in China Series C: Life Sciences
Volume
56
Issue
9
Publish Date
2013
Start Page
780
End Page
787
DOI
10.1007/s11427-013-4522-0

Fine-tuning robot-assisted radical prostatectomy planning with MRI

Authors
Finley, DS; Margolis, D; Raman, SS; Ellingson, BM; Natarajan, S; Tan, N; Huang, J; Reiter, RE
MLA Citation
Finley, DS, Margolis, D, Raman, SS, Ellingson, BM, Natarajan, S, Tan, N, Huang, J, and Reiter, RE. "Fine-tuning robot-assisted radical prostatectomy planning with MRI." Urologic Oncology: Seminars and Original Investigations 31.6 (August 2013): 766-775.
Source
crossref
Published In
Urologic Oncology: Seminars and Original Investigations
Volume
31
Issue
6
Publish Date
2013
Start Page
766
End Page
775
DOI
10.1016/j.urolonc.2011.07.013

Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee

Authors
Ittmann, M; Huang, J; Radaelli, E; Martin, P; Signoretti, S; Sullivan, R; Simons, BW; Ward, JM; Robinson, BD; Chu, GC; Loda, M; Thomas, G; Borowsky, A; Cardiff, RD
MLA Citation
Ittmann, M, Huang, J, Radaelli, E, Martin, P, Signoretti, S, Sullivan, R, Simons, BW, Ward, JM, Robinson, BD, Chu, GC, Loda, M, Thomas, G, Borowsky, A, and Cardiff, RD. "Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee." Cancer Research 73.9 (May 1, 2013): 2718-2736.
Source
crossref
Published In
Cancer Research
Volume
73
Issue
9
Publish Date
2013
Start Page
2718
End Page
2736
DOI
10.1158/0008-5472.CAN-12-4213

Neuroendocrine differentiation of prostate cancer

Authors
Li, Z; Chen, CJ; Wang, JK; Hsia, E; Li, W; Squires, J; Sun, Y; Huang, J
MLA Citation
Li, Z, Chen, CJ, Wang, JK, Hsia, E, Li, W, Squires, J, Sun, Y, and Huang, J. "Neuroendocrine differentiation of prostate cancer." Asian Journal of Andrology 15.3 (May 2013): 328-332.
Source
crossref
Published In
Asian journal of andrology
Volume
15
Issue
3
Publish Date
2013
Start Page
328
End Page
332
DOI
10.1038/aja.2013.7

Hyperactivated JNK Is a Therapeutic Target in pVHL-Deficient Renal Cell Carcinoma

Authors
An, J; Liu, H; Magyar, CE; Guo, Y; Veena, MS; Srivatsan, ES; Huang, J; Rettig, MB
MLA Citation
An, J, Liu, H, Magyar, CE, Guo, Y, Veena, MS, Srivatsan, ES, Huang, J, and Rettig, MB. "Hyperactivated JNK Is a Therapeutic Target in pVHL-Deficient Renal Cell Carcinoma." Cancer Research 73.4 (February 15, 2013): 1374-1385.
Source
crossref
Published In
Cancer Research
Volume
73
Issue
4
Publish Date
2013
Start Page
1374
End Page
1385
DOI
10.1158/0008-5472.CAN-12-2362

Targeted Biopsy in the Detection of Prostate Cancer Using an Office Based Magnetic Resonance Ultrasound Fusion Device

Authors
Sonn, GA; Natarajan, S; Margolis, DJA; MacAiran, M; Lieu, P; Huang, J; Dorey, FJ; Marks, LS
MLA Citation
Sonn, GA, Natarajan, S, Margolis, DJA, MacAiran, M, Lieu, P, Huang, J, Dorey, FJ, and Marks, LS. "Targeted Biopsy in the Detection of Prostate Cancer Using an Office Based Magnetic Resonance Ultrasound Fusion Device." The Journal of Urology 189.1 (January 2013): 86-92.
Source
crossref
Published In
The Journal of Urology
Volume
189
Issue
1
Publish Date
2013
Start Page
86
End Page
92
DOI
10.1016/j.juro.2012.08.095

Molecular Pathology of Prostate Cancer Revealed by Next Generation Sequencing: Opportunities for Genome-Based Personalized Therapy

Authors
Huang, J; Wang, JK; Sun, Y
MLA Citation
Huang, J, Wang, JK, and Sun, Y. "Molecular Pathology of Prostate Cancer Revealed by Next Generation Sequencing: Opportunities for Genome-Based Personalized Therapy." Current Opinion in Urology 23 (2013): 189-193.
Source
manual
Published In
Current Opinion in Urology
Volume
23
Publish Date
2013
Start Page
189
End Page
193

Frequent TMPRSS2-ERG rearrangement in prostatic small cell carcinoma detected by fluorescence in situ hybridization: the superiority of FISH over ERG immunohistochemistry

Authors
Schelling, LA; Williamson, SR; Zhang, S; Yao, JL; Wang, M; Huang, J; Montironi, R; Lopez-Beltran, A; Emerson, RE; Idrees, MT; Osunkoya, AO; Man, YG; MacLennan, GT; Baldridge, LA; Compérat, E; Cheng, L
MLA Citation
Schelling, LA, Williamson, SR, Zhang, S, Yao, JL, Wang, M, Huang, J, Montironi, R, Lopez-Beltran, A, Emerson, RE, Idrees, MT, Osunkoya, AO, Man, YG, MacLennan, GT, Baldridge, LA, Compérat, E, and Cheng, L. "Frequent TMPRSS2-ERG rearrangement in prostatic small cell carcinoma detected by fluorescence in situ hybridization: the superiority of FISH over ERG immunohistochemistry." Human Pathology 44 (2013): 2227-2233.
Source
manual
Published In
Human Pathology
Volume
44
Publish Date
2013
Start Page
2227
End Page
2233

Recent development in the staging of bladder urothelial carcinoma

Authors
Cheng, L; Wang, X; Teng, X; Huang, J; Na, Y
MLA Citation
Cheng, L, Wang, X, Teng, X, Huang, J, and Na, Y. "Recent development in the staging of bladder urothelial carcinoma." Chinese Journal of Urology 34 (2013): 328-332.
Source
manual
Published In
Chinese Journal of Urology
Volume
34
Publish Date
2013
Start Page
328
End Page
332

Long Noncoding RNA MALAT-1 is a New Potential Therapeutic Target for Castration-Resistant Prostate Cancer

Authors
Ren, S; Liu, Y; Xu, W; Sun, Y; Lu, J; Wang, F; Wei, M; Shen, J; Hou, J; Gao, X; Xu, C; Huang, J; Zhao, Y; Sun, Y
MLA Citation
Ren, S, Liu, Y, Xu, W, Sun, Y, Lu, J, Wang, F, Wei, M, Shen, J, Hou, J, Gao, X, Xu, C, Huang, J, Zhao, Y, and Sun, Y. "Long Noncoding RNA MALAT-1 is a New Potential Therapeutic Target for Castration-Resistant Prostate Cancer." Journal of Urology 190.6 (2013): 2278-2287.
Source
manual
Published In
Journal of Urology
Volume
190
Issue
6
Publish Date
2013
Start Page
2278
End Page
2287

Renal tumors: diagnostic and prognostic biomarkers

Authors
Huang, J; Tan, PH; Cheng, L; Rioux-Leclercq, N; Merino, MJ; Netto, G; Reuter, VE; Shen, SS; Grignon, DJ; Montironi, R; Egevad, L; Srigley, JR; Delahunt, B; Moch, H; ISUP Renal Tumor Panel,
MLA Citation
Huang, J, Tan, PH, Cheng, L, Rioux-Leclercq, N, Merino, MJ, Netto, G, Reuter, VE, Shen, SS, Grignon, DJ, Montironi, R, Egevad, L, Srigley, JR, Delahunt, B, Moch, H, and ISUP Renal Tumor Panel, . "Renal tumors: diagnostic and prognostic biomarkers." American Journal of Surgical Pathology 37 (2013): 1518-1531.
Source
manual
Published In
American Journal of Surgical Pathology
Volume
37
Publish Date
2013
Start Page
1518
End Page
1531

Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers

Authors
Chen, R; Zeng, X; Zhang, R; Huang, J; Kuang, X; Yang, J; Liu, J; Tawfik, O; Brantly Thrasher, J; Li, B
MLA Citation
Chen, R, Zeng, X, Zhang, R, Huang, J, Kuang, X, Yang, J, Liu, J, Tawfik, O, Brantly Thrasher, J, and Li, B. "Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers." Urologic Oncology: Seminars and Original Investigations 32.5 (2013): 524-536.
Source
manual
Published In
Urologic Oncology: Seminars and Original Investigations
Volume
32
Issue
5
Publish Date
2013
Start Page
524
End Page
536

Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets

Authors
Drake, JM; Graham, NA; Lee, JK; Stoyanova, T; Faltermeier, CM; Sud, S; Titz, B; Huang, J; Pienta, KJ; Graeber, TG; Witte, ON
MLA Citation
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Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells

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Stem-Like Epithelial Cells Are Concentrated in the Distal End of the Fallopian Tube: A Site for Injury and Serous Cancer Initiation

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Paik, DY; Janzen, DM; Schafenacker, AM; Velasco, VS; Shung, MS; Cheng, D; Huang, J; Witte, ON; Memarzadeh, S
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Paik, DY, Janzen, DM, Schafenacker, AM, Velasco, VS, Shung, MS, Cheng, D, Huang, J, Witte, ON, and Memarzadeh, S. "Stem-Like Epithelial Cells Are Concentrated in the Distal End of the Fallopian Tube: A Site for Injury and Serous Cancer Initiation." STEM CELLS 30.11 (November 2012): 2487-2497.
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Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis

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Liu, N; Tai, S; Ding, B; Thor, RK; Bhuta, S; Sun, Y; Huang, J
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Liu, N, Tai, S, Ding, B, Thor, RK, Bhuta, S, Sun, Y, and Huang, J. "Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis." Endocrine Related Cancer 19.5 (September 21, 2012): 711-723.
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Radical prostatectomy: value of prostate MRI in surgical planning

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Combination of Rad001 (Everolimus) and Propachlor Synergistically Induces Apoptosis through Enhanced Autophagy in Prostate Cancer Cells

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Tai, S, Sun, Y, Liu, N, Ding, B, Hsia, E, Bhuta, S, Thor, RK, Damoiseaux, R, Liang, C, and Huang, J. "Combination of Rad001 (Everolimus) and Propachlor Synergistically Induces Apoptosis through Enhanced Autophagy in Prostate Cancer Cells." Molecular Cancer Therapeutics 11.6 (June 1, 2012): 1320-1331.
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Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway

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The PSA−/lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration

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Qin, J; Liu, X; Laffin, B; Chen, X; Choy, G; Jeter, CR; Calhoun-Davis, T; Li, H; Palapattu, GS; Pang, S; Lin, K; Huang, J; Ivanov, I; Li, W; Suraneni, MV; Tang, DG
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Qin, J, Liu, X, Laffin, B, Chen, X, Choy, G, Jeter, CR, Calhoun-Davis, T, Li, H, Palapattu, GS, Pang, S, Lin, K, Huang, J, Ivanov, I, Li, W, Suraneni, MV, and Tang, DG. "The PSA−/lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration." Cell Stem Cell 10.5 (May 2012): 556-569.
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Overexpression of SKI Oncoprotein Leads to p53 Degradation through Regulation of MDM2 Protein Sumoylation

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Ding, B, Sun, Y, and Huang, J. "Overexpression of SKI Oncoprotein Leads to p53 Degradation through Regulation of MDM2 Protein Sumoylation." Journal of Biological Chemistry 287.18 (April 27, 2012): 14621-14630.
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Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells

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Mulholland, DJ; Kobayashi, N; Ruscetti, M; Zhi, A; Tran, LM; Huang, J; Gleave, M; Wu, H
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Mulholland, DJ, Kobayashi, N, Ruscetti, M, Zhi, A, Tran, LM, Huang, J, Gleave, M, and Wu, H. "Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells." Cancer Research 72.7 (April 1, 2012): 1878-1889.
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Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression

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Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling

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Stoyanova, T; Goldstein, AS; Cai, H; Drake, JM; Huang, J; Witte, ON
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Stoyanova, T, Goldstein, AS, Cai, H, Drake, JM, Huang, J, and Witte, ON. "Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling." Genes & development 26 (2012): 2271-2285.
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Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling

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Zong, Y; Huang, J; Sankarasharma, D; Morikawa, T; Fukayama, M; Epstein, JI; Chada, KK; Witte, ON
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PC3 is a cell line characteristic of prostatic small cell carcinoma

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Tai, S; Sun, Y; Squires, JM; Zhang, H; Oh, WK; Liang, C-Z; Huang, J
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Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth

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Clinical application of a 3D ultrasound-guided prostate biopsy system

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The landscape of EGFR pathways and personalized management of non-small-cell lung cancer

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Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers

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Tyrosine Kinase ETK/BMX Is Up-Regulated in Bladder Cancer and Predicts Poor Prognosis in Patients with Cystectomy

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Guo, S; Sun, F; Guo, Z; Li, W; Alfano, A; Chen, H; Magyar, CE; Huang, J; Chai, TC; Qiu, S; Qiu, Y
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Invasive Prostate Carcinoma Driven by c-Src and Androgen Receptor Synergy

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Cai, H, Babic, I, Wei, X, Huang, J, and Witte, ON. "Invasive Prostate Carcinoma Driven by c-Src and Androgen Receptor Synergy." Cancer Research 71.3 (February 1, 2011): 862-872.
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Novel genetic loci associated with prostate cancer in the Japanese population

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Sun, Y, and Huang, J-T. "Novel genetic loci associated with prostate cancer in the Japanese population." Asian Journal of Andrology 13.1 (January 2011): 120-121.
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Thrombin Expression in Prostate: A Novel Finding

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Kohli, M; Williams, K; Yao, JL; Dennis, RA; Huang, J; Reeder, J; Ricke, WA
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Methods for the purification and direct transformation of epithelial progenitor cells from primary human prostate

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Goldstein, AS, Drake, JM, Burnes, DL, Finley, DS, Zhang, H, Reiter, RE, Huang, J, and Witte, ON. "Methods for the purification and direct transformation of epithelial progenitor cells from primary human prostate." Nature Protocols 6 (2011): 656-667.
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ERG-TMPRSS2 Rearrangement is Shared by Concurrent Prostatic Adenocarcinoma and Prostatic Small Cell Carcinoma and Absent in Small Cell Carcinoma of the Urinary Bladder: Further Evidence Supporting Monoclonal Origin

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Williamson, SR, Zhang, S, Yao, JL, Huang, J, Lopez-Beltran, A, Shen, S, Osunkoya, AO, MacLennan, GT, Montironi, R, and Cheng, L. "ERG-TMPRSS2 Rearrangement is Shared by Concurrent Prostatic Adenocarcinoma and Prostatic Small Cell Carcinoma and Absent in Small Cell Carcinoma of the Urinary Bladder: Further Evidence Supporting Monoclonal Origin." Modern Pathology 24 (2011): 1120-1127.
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High Grade Neuroendocrine Carcinomas of the Lung Highly Express EZH2 but Carcinoids Do Not

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Findeis-Hosey, JJ; Huang, J; Li, F; Yang, Q; McMahon, LA; Xu, H
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Findeis-Hosey, JJ, Huang, J, Li, F, Yang, Q, McMahon, LA, and Xu, H. "High Grade Neuroendocrine Carcinomas of the Lung Highly Express EZH2 but Carcinoids Do Not." Human Pathology 42 (2011): 867-872.
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SYT-SSX1 (Synovial Sarcoma Translocated) regulates PIASy to cause overexpression of NCOA3

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Sun, Y; Perera, J; Rubin, BP; Huang, J
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Sun, Y, Perera, J, Rubin, BP, and Huang, J. "SYT-SSX1 (Synovial Sarcoma Translocated) regulates PIASy to cause overexpression of NCOA3." The Journal of biological chemistry 286 (2011): 18623-18632.
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A critical evaluation of the current histological grading system for non-invasive papillary urothelial carcinoma

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Cheng, L; Zhang, S; Huang, J; Li, N; Na, Y
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Cheng, L, Zhang, S, Huang, J, Li, N, and Na, Y. "A critical evaluation of the current histological grading system for non-invasive papillary urothelial carcinoma." Chinese Journal of Urology 32 (2011): 427-431.
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Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal

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Memarzadeh, S; Cai, H; Janzen, DM; Xin, L; Likacs, R; Riedinger, M; Zong, Y; Degendt, K; Verhoeven, G; Huang, J; White, ON
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Memarzadeh, S, Cai, H, Janzen, DM, Xin, L, Likacs, R, Riedinger, M, Zong, Y, Degendt, K, Verhoeven, G, Huang, J, and White, ON. "Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal." Proceedings of the National Academy of Sciences of USA 108 (2011): 7962-7967.
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Do neuroendocrine cells come up large in small cell lung cancer?

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Goldstein, AS, and Huang, J. "Do neuroendocrine cells come up large in small cell lung cancer?." Cell Cycle 10 (2011): 3627-3627.
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The oncogenic gene fusion TMPRSS2: ERG is not a diagnostic or prognostic marker for ovarian cancer

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Schauer, IG; Zhang, J; Mercado-Uribe, I; Deavers, MT; Huang, J; Liu, J
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Schauer, IG, Zhang, J, Mercado-Uribe, I, Deavers, MT, Huang, J, and Liu, J. "The oncogenic gene fusion TMPRSS2: ERG is not a diagnostic or prognostic marker for ovarian cancer." International Journal of Clinical and. Experimental Pathology 4 (2011): 644-650.
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Prognostic Value and Function of KLF4 in Prostate Cancer: RNAa and Vector-Mediated Overexpression Identify KLF4 as an Inhibitor of Tumor Cell Growth and Migration

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Wang, J; Place, RF; Huang, V; Wang, X; Noonan, EJ; Magyar, CE; Huang, J; Li, L-C
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Wang, J, Place, RF, Huang, V, Wang, X, Noonan, EJ, Magyar, CE, Huang, J, and Li, L-C. "Prognostic Value and Function of KLF4 in Prostate Cancer: RNAa and Vector-Mediated Overexpression Identify KLF4 as an Inhibitor of Tumor Cell Growth and Migration." Cancer Research 70.24 (December 15, 2010): 10182-10191.
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The influence of percutaneous nephrolithotomy on human systemic stress response, SIRS and renal function

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Shen, P, Wei, W, Yang, X, Zeng, H, Li, X, Yang, J, Wang, J, and Huang, J. "The influence of percutaneous nephrolithotomy on human systemic stress response, SIRS and renal function." Urological Research 38.5 (October 2010): 403-408.
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Neurosteroid transport by the organic solute transporter OSTα-OSTβ

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Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation

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CXCR2 Promotes Ovarian Cancer Growth through Dysregulated Cell Cycle, Diminished Apoptosis, and Enhanced Angiogenesis

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Yang, G; Rosen, DG; Liu, G; Yang, F; Guo, X; Xiao, X; Xue, F; Mercado-Uribe, I; Huang, J; Lin, S-H; Mills, GB; Liu, J
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Identification of a Cell of Origin for Human Prostate Cancer

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Goldstein, AS; Huang, J; Guo, C; Garraway, IP; Witte, ON
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Goldstein, AS, Huang, J, Guo, C, Garraway, IP, and Witte, ON. "Identification of a Cell of Origin for Human Prostate Cancer." Science 329.5991 (July 30, 2010): 568-571.
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329
Issue
5991
Publish Date
2010
Start Page
568
End Page
571
DOI
10.1126/science.1189992

Re: Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

Authors
Marks, LS; Huang, J
MLA Citation
Marks, LS, and Huang, J. "Re: Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer." European Urology 57.4 (April 2010): 727-728.
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Published In
European Urology
Volume
57
Issue
4
Publish Date
2010
Start Page
727
End Page
728
DOI
10.1016/j.eururo.2010.01.028

Sex Determining Region Y-Box 2 (SOX2) Is a Potential Cell-Lineage Gene Highly Expressed in the Pathogenesis of Squamous Cell Carcinomas of the Lung

Authors
Yuan, P; Kadara, H; Behrens, C; Tang, X; Woods, D; Solis, LM; Huang, J; Spinola, M; Dong, W; Yin, G; Fujimoto, J; Kim, E; Xie, Y; Girard, L; Moran, C; Hong, WK; Minna, JD; Wistuba, II
MLA Citation
Yuan, P, Kadara, H, Behrens, C, Tang, X, Woods, D, Solis, LM, Huang, J, Spinola, M, Dong, W, Yin, G, Fujimoto, J, Kim, E, Xie, Y, Girard, L, Moran, C, Hong, WK, Minna, JD, and Wistuba, II. "Sex Determining Region Y-Box 2 (SOX2) Is a Potential Cell-Lineage Gene Highly Expressed in the Pathogenesis of Squamous Cell Carcinomas of the Lung." Ed. ATY Lau. PLoS ONE 5.2 (February 9, 2010): e9112-e9112.
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PloS one
Volume
5
Issue
2
Publish Date
2010
Start Page
e9112
End Page
e9112
DOI
10.1371/journal.pone.0009112

A Seminal Finding for Prostate Cancer?

Authors
Huang, J; Witte, ON
MLA Citation
Huang, J, and Witte, ON. "A Seminal Finding for Prostate Cancer?." New England Journal of Medicine 362.2 (January 14, 2010): 175-176.
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The New England journal of medicine
Volume
362
Issue
2
Publish Date
2010
Start Page
175
End Page
176
DOI
10.1056/NEJMcibr0909965

Basal epithelial stem cells are efficient targets for prostate cancer initiation

Authors
Lawson, DA; Zong, Z; Memarzadeh, S; Xin, L; Huang, J; Witte, ON
MLA Citation
Lawson, DA, Zong, Z, Memarzadeh, S, Xin, L, Huang, J, and Witte, ON. "Basal epithelial stem cells are efficient targets for prostate cancer initiation." Proceedings of the National Academy of Sciences of USA 107 (2010): 2610-2615.
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Proceedings of the National Academy of Sciences of USA
Volume
107
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2010
Start Page
2610
End Page
2615

A novel in vitro assay of human prostate cancer tumor initiation

Authors
Silvers, CR; Williams, K; Salamone, L; Huang, J; Jordan, CT; Zhou, H; Palapattu, GS
MLA Citation
Silvers, CR, Williams, K, Salamone, L, Huang, J, Jordan, CT, Zhou, H, and Palapattu, GS. "A novel in vitro assay of human prostate cancer tumor initiation." Prostate 70 (2010): 1379-1387.
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Prostate
Volume
70
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2010
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1379
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1387

Possibility for Platinum Chemotherapy Treatment for HRPC Patients?

Authors
Brick, A; Niu, J; Huang, J; Oh, WK
MLA Citation
Brick, A, Niu, J, Huang, J, and Oh, WK. "Possibility for Platinum Chemotherapy Treatment for HRPC Patients?." Drug Management of Prostate Cancer. Ed. WD Figg, CH Chau, and EJ Small. NJ: Humana Press, 2010. 153-161. (Chapter)
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2010
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153
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Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium

Authors
Memarzadeh, S; Zong, Y; Janzen, DM; Goldstein, AS; Cheng, D; Kurita, T; Schafenacker, AM; Huang, J; Witte, ON
MLA Citation
Memarzadeh, S, Zong, Y, Janzen, DM, Goldstein, AS, Cheng, D, Kurita, T, Schafenacker, AM, Huang, J, and Witte, ON. "Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium." Proceedings of the National Academy of Sciences of USA 107 (2010): 17298-17303.
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Issue
107
Publish Date
2010
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17298
End Page
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Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, invasion, metastasis and castration resistance

Authors
Tanaka, H; Kono, E; Tran, CP; Miyazaki, H; Yamashiro, J; Shimomura, T; Ladan, F; Wada, R; Huang, J; Vessella, RL; An, J; Horvath, S; Gleave, M; Retting, MB; Wainberg, ZA; Reiter, RE
MLA Citation
Tanaka, H, Kono, E, Tran, CP, Miyazaki, H, Yamashiro, J, Shimomura, T, Ladan, F, Wada, R, Huang, J, Vessella, RL, An, J, Horvath, S, Gleave, M, Retting, MB, Wainberg, ZA, and Reiter, RE. "Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, invasion, metastasis and castration resistance." Nature Medicine 16 (2010): 1414-1420.
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Published In
Nature Medicine
Volume
16
Publish Date
2010
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1414
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1420

Selective expression of CD44, a putative prostate cancer stem cell marker, in neuroendocrine tumor cells of human prostate cancer

Authors
Palapattu, GS; Wu, C; Silvers, CR; Martin, HB; Williams, K; Salamone, L; Bushnell, T; Huang, L-S; Yang, Q; Huang, J
MLA Citation
Palapattu, GS, Wu, C, Silvers, CR, Martin, HB, Williams, K, Salamone, L, Bushnell, T, Huang, L-S, Yang, Q, and Huang, J. "Selective expression of CD44, a putative prostate cancer stem cell marker, in neuroendocrine tumor cells of human prostate cancer." The Prostate 69.7 (May 15, 2009): 787-798.
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The Prostate
Volume
69
Issue
7
Publish Date
2009
Start Page
787
End Page
798
DOI
10.1002/pros.20928

Small Cell Carcinoma of the Prostate

Authors
Wagner, DG; Huang, J
MLA Citation
Wagner, DG, and Huang, J. "Small Cell Carcinoma of the Prostate." (April 20, 2009).
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Publish Date
2009

CD44 expression is a feature of prostatic small cell Carcinoma and Distinguishes it from its Mimickers

Authors
Simon, RA; di Sant'Agnese, PA; Huang, L-S; Xu, H; Yao, JL; Yang, Q; Liang, S; Liu, J; Yu, R; Cheng, L; Oh, WK; Palapattu, GS; Wei, J; Huang, J
MLA Citation
Simon, RA, di Sant'Agnese, PA, Huang, L-S, Xu, H, Yao, JL, Yang, Q, Liang, S, Liu, J, Yu, R, Cheng, L, Oh, WK, Palapattu, GS, Wei, J, and Huang, J. "CD44 expression is a feature of prostatic small cell Carcinoma and Distinguishes it from its Mimickers." Human Pathology 40.2 (February 2009): 252-258.
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Human Pathology
Volume
40
Issue
2
Publish Date
2009
Start Page
252
End Page
258
DOI
10.1016/j.humpath.2008.07.014

Neuroendocrine differentiation in prostate cancer

Authors
Sun, Y; Niu, J; Huang, J
MLA Citation
Sun, Y, Niu, J, and Huang, J. "Neuroendocrine differentiation in prostate cancer." American Journal of Translational Research 1 (2009): 148-162.
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Published In
American Journal of Translational Research
Volume
1
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2009
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148
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Dysplastic ("in-situ") Lesions in multifocal renal oncocytomas (oncocytosis)

Authors
Huang, J; Lee, P; Mikami, Y; Melamed, J
MLA Citation
Huang, J, Lee, P, Mikami, Y, and Melamed, J. "Dysplastic ("in-situ") Lesions in multifocal renal oncocytomas (oncocytosis)." International Journal of Clinical and. Experimental Pathology 2 (2009): 583-587.
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International Journal of Clinical and. Experimental Pathology
Volume
2
Publish Date
2009
Start Page
583
End Page
587

Ionizing Radiation Induces Prostate Cancer Neuroendocrine Differentiation through Interplay of CREB and ATF2: Implications for Disease Progression

Authors
Deng, X; Liu, H; Huang, J; Cheng, L; Keller, ET; Parsons, SJ; Hu, C-D
MLA Citation
Deng, X, Liu, H, Huang, J, Cheng, L, Keller, ET, Parsons, SJ, and Hu, C-D. "Ionizing Radiation Induces Prostate Cancer Neuroendocrine Differentiation through Interplay of CREB and ATF2: Implications for Disease Progression." Cancer Research 68.23 (December 1, 2008): 9663-9670.
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Cancer Research
Volume
68
Issue
23
Publish Date
2008
Start Page
9663
End Page
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DOI
10.1158/0008-5472.CAN-08-2229

Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors

Authors
Li, L; Xu, H; Spaulding, BO; Cheng, L; Simon, R; Yao, JL; di Sant'Agnese, PA; Bourne, PA; Huang, J
MLA Citation
Li, L, Xu, H, Spaulding, BO, Cheng, L, Simon, R, Yao, JL, di Sant'Agnese, PA, Bourne, PA, and Huang, J. "Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors." Human Pathology 39.8 (August 2008): 1205-1211.
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Human Pathology
Volume
39
Issue
8
Publish Date
2008
Start Page
1205
End Page
1211
DOI
10.1016/j.humpath.2007.12.012

Schwannoma of the Kidney

Authors
Gobbo, S; Eble, JN; Huang, J; Grignon, DJ; Wang, M; Martignoni, G; Brunelli, M; Cheng, L
MLA Citation
Gobbo, S, Eble, JN, Huang, J, Grignon, DJ, Wang, M, Martignoni, G, Brunelli, M, and Cheng, L. "Schwannoma of the Kidney." Modern Pathology 21.6 (June 2008): 779-783.
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Modern Pathology
Volume
21
Issue
6
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2008
Start Page
779
End Page
783
DOI
10.1038/modpathol.2008.52

Small cell carcinoma of the prostate

Authors
Yao, JL; Huang, J; Anthony di Sant’Agnese, P
MLA Citation
Yao, JL, Huang, J, and Anthony di Sant’Agnese, P. "Small cell carcinoma of the prostate." Diagnostic Histopathology 14.3 (March 2008): 117-121.
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Volume
14
Issue
3
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2008
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117
End Page
121
DOI
10.1016/j.mpdhp.2008.02.005

A Phase II study of carboplatin plus docetaxel in men with metastatic hormone refractory prostate cancer who are refractory to docetaxel

Authors
Ross, RW; Beer, TM; Jacobus, S; Bubley, GT; Taplin, M-E; Ryan, C; Huang, J; Oh, WK
MLA Citation
Ross, RW, Beer, TM, Jacobus, S, Bubley, GT, Taplin, M-E, Ryan, C, Huang, J, and Oh, WK. "A Phase II study of carboplatin plus docetaxel in men with metastatic hormone refractory prostate cancer who are refractory to docetaxel." Cancer 112 (2008): 521-526.
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112
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2008
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521
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526

A Phase II study of carboplatin plus docetaxel in men with metastatic hormone refractory prostate cancer who are refractory to docetaxel

Authors
Ross, RW; Beer, TM; Jacobus, S; Bubley, GT; Taplin, M-E; Ryan, C; Huang, J; Oh, WK
MLA Citation
Ross, RW, Beer, TM, Jacobus, S, Bubley, GT, Taplin, M-E, Ryan, C, Huang, J, and Oh, WK. "A Phase II study of carboplatin plus docetaxel in men with metastatic hormone refractory prostate cancer who are refractory to docetaxel." Cancer 112 (2008): 521-526.
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Cancer
Volume
112
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2008
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521
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526

Expression of Claudin-7 in Benign Kidney and Kidney Tumors

Authors
Li, L; Yao, JL; di Sant' Agnese, PA; Bourne, PA; Picken, MM; Young, AN; Shen, SS; Huang, J
MLA Citation
Li, L, Yao, JL, di Sant' Agnese, PA, Bourne, PA, Picken, MM, Young, AN, Shen, SS, and Huang, J. "Expression of Claudin-7 in Benign Kidney and Kidney Tumors." International Journal of Clinical and. Experimental Pathology 1 (2008): 57-64.
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International Journal of Clinical and. Experimental Pathology
Volume
1
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2008
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57
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64

Mucinous Tubular and Spindle Cell Carcinoma of the Kidney with Sarcomatoid Differentiation

Authors
Simon, RA; di Sant' Agnese, PA; Palapattu, GS; Singer, E; Candelario, G; Huang, J; Yao, JL
MLA Citation
Simon, RA, di Sant' Agnese, PA, Palapattu, GS, Singer, E, Candelario, G, Huang, J, and Yao, JL. "Mucinous Tubular and Spindle Cell Carcinoma of the Kidney with Sarcomatoid Differentiation." International Journal for Computer Assisted Radiology and Surgery 1 (2008): 180-184.
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International Journal for Computer Assisted Radiology and Surgery
Volume
1
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2008
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180
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184

Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1

Authors
Johnson, AM; O'Connell, MJ; Miyamoto, H; Huang, J; Yao, JL; Messing, EM; Reeder, JE
MLA Citation
Johnson, AM, O'Connell, MJ, Miyamoto, H, Huang, J, Yao, JL, Messing, EM, and Reeder, JE. "Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1." BMC Urology 8.7 (2008).
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Published In
BMC Urology
Volume
8
Issue
7
Publish Date
2008

A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor

Authors
Cai, Y; Lee, Y-F; Li, G; Liu, S; Bao, B-Y; Huang, J; Hsu, CL; Chang, C
MLA Citation
Cai, Y, Lee, Y-F, Li, G, Liu, S, Bao, B-Y, Huang, J, Hsu, CL, and Chang, C. "A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor." International Jouranl of Cancer 123 (2008): 195-201.
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Published In
International Jouranl of Cancer
Volume
123
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2008
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195
End Page
201

Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma

Authors
Lei, JL; Huang, J
MLA Citation
Lei, JL, and Huang, J. "Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma." Expert Opinion on Medical Diagnostics 2 (2008): 151-159.
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Published In
Expert Opinion on Medical Diagnostics
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2
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2008
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Co-opted Jnk/Sapk signaling in Wnt/b-catenin-induced tumorigenesis

Authors
Liu, B; Yu, H-MI; Huang, J; Hsu, W
MLA Citation
Liu, B, Yu, H-MI, Huang, J, and Hsu, W. "Co-opted Jnk/Sapk signaling in Wnt/b-catenin-induced tumorigenesis." Neoplasia 10 (2008): 1004-1013.
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Neoplasia
Volume
10
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2008
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1013

Absence of Y chromosome in human placental site trophoblastic tumor

Authors
Hui, P; Wang, HL; Chu, P; Yang, B; Huang, J; Baergen, RN; Sklar, J; Yang, XJ; Soslow, RA
MLA Citation
Hui, P, Wang, HL, Chu, P, Yang, B, Huang, J, Baergen, RN, Sklar, J, Yang, XJ, and Soslow, RA. "Absence of Y chromosome in human placental site trophoblastic tumor." Modern Pathology 20.10 (October 2007): 1055-1060.
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20
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10
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2007
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1055
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DOI
10.1038/modpathol.3800941

Is there a role for platinum chemotherapy in the treatment of patients with hormone-refractory prostate cancer?

Authors
Oh, WK; Tay, M-H; Huang, J
MLA Citation
Oh, WK, Tay, M-H, and Huang, J. "Is there a role for platinum chemotherapy in the treatment of patients with hormone-refractory prostate cancer?." Cancer 109.3 (February 1, 2007): 477-486.
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109
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3
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2007
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477
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486
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10.1002/cncr.22439

Malakoplakia of the Prostate on Needle Core Biopsy: A Case Report and Review of the Literature

Authors
Wagner, D; Joseph, J; Huang, J; Xu, H
MLA Citation
Wagner, D, Joseph, J, Huang, J, and Xu, H. "Malakoplakia of the Prostate on Needle Core Biopsy: A Case Report and Review of the Literature." International Journal of Surgical Pathology 15.1 (January 1, 2007): 86-89.
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International Journal of Surgical Pathology
Volume
15
Issue
1
Publish Date
2007
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86
End Page
89
DOI
10.1177/1066896906295892

Function and molecular mechanisms of neuroendocrine cells in prostate cancer

Authors
Huang, J; Wu, C; di Sant'Agnese, PA; Yao, JL; Cheng, L; Na, Y
MLA Citation
Huang, J, Wu, C, di Sant'Agnese, PA, Yao, JL, Cheng, L, and Na, Y. "Function and molecular mechanisms of neuroendocrine cells in prostate cancer." Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 29 (2007): 128-138.
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Published In
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology
Volume
29
Publish Date
2007
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128
End Page
138

Soft tissue tumors in the prostate

Authors
Wagner, DG; Yao, JL; di Sant'Agnese, PA; Cheng, L; Lopez-Beltran, A; Montironi, R; Huang, J
MLA Citation
Wagner, DG, Yao, JL, di Sant'Agnese, PA, Cheng, L, Lopez-Beltran, A, Montironi, R, and Huang, J. "Soft tissue tumors in the prostate." Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 29 (2007): 341-350.
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Published In
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology
Volume
29
Publish Date
2007
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341
End Page
350

Littoral cell angioma of spleen: Radiologic-pathologic correlation

Authors
Bhatt, S; Huang, J; Dogra, VS
MLA Citation
Bhatt, S, Huang, J, and Dogra, VS. "Littoral cell angioma of spleen: Radiologic-pathologic correlation." AJR. American journal of roentgenology 188.5 (2007): 1365-1366.
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Published In
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Volume
188
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5
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2007
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1365
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1366

The expression and function of androgen receptor coactivator p44 and protein arginine methyltransfersase 5 (PRMT5) in the developing testis and testicular tumors

Authors
Huang, J; Liang, JJ; Wang, Z; Chiriboga, L; Greco, MA; Shapiro, E; Huang, H; Peng, Y; Melamed, J; Garabedian, M; Lee, P
MLA Citation
Huang, J, Liang, JJ, Wang, Z, Chiriboga, L, Greco, MA, Shapiro, E, Huang, H, Peng, Y, Melamed, J, Garabedian, M, and Lee, P. "The expression and function of androgen receptor coactivator p44 and protein arginine methyltransfersase 5 (PRMT5) in the developing testis and testicular tumors." Journal of Urology 177.5 (2007): 1918-1922.
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Published In
Journal of Urology
Volume
177
Issue
5
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2007
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1918
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1922

PI3 kinase-AKT-mTOR pathway is involved in neuroendocrine differentiation of prostate cancer

Authors
Wu, C; Huang, J
MLA Citation
Wu, C, and Huang, J. "PI3 kinase-AKT-mTOR pathway is involved in neuroendocrine differentiation of prostate cancer." The Journal of biological chemistry 282.6 (2007): 3571-3583.
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The Journal of biological chemistry
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282
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6
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2007
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The function of Interleukin-8 in prostate cancer

Authors
Wu, C; Chen, G; Na, Y; Xin, D; Yao, JL; di Xant' Agnese, PA; Huang, J
MLA Citation
Wu, C, Chen, G, Na, Y, Xin, D, Yao, JL, di Xant' Agnese, PA, and Huang, J. "The function of Interleukin-8 in prostate cancer." Progress in Chemokine Research. Ed. WP Links. New York: Nova Science Publishers, 2007. 149-156. (Chapter)
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2007
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156

Molecular Genetic Evidence Supporting the Neoplastic Nature of Stromal Cells in “Fibrosis” After Chemotherapy for Testicular Germ Cell Tumors

Authors
Cheng, L; Zhang, S; Wang, M; Davidson, DD; Morton, MJ; Huang, J; Zheng, S; Jones, TD; Beck, SD; Foster, RS
MLA Citation
Cheng, L, Zhang, S, Wang, M, Davidson, DD, Morton, MJ, Huang, J, Zheng, S, Jones, TD, Beck, SD, and Foster, RS. "Molecular Genetic Evidence Supporting the Neoplastic Nature of Stromal Cells in “Fibrosis” After Chemotherapy for Testicular Germ Cell Tumors." American Journal of Pathology 213 (2007): 65-71.
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American Journal of Pathology
Volume
213
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2007
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65
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Mechanical properties of human prostate tissue in the context of surgical needle insertion

Authors
Podder, TK; Sherman, J; Li, L; Joseph, J; Rubens, DR; Messing, EM; Huang, J; Yu, Y
MLA Citation
Podder, TK, Sherman, J, Li, L, Joseph, J, Rubens, DR, Messing, EM, Huang, J, and Yu, Y. "Mechanical properties of human prostate tissue in the context of surgical needle insertion." International Journal for Computer Assisted Radiology and Surgery 2.Suppl I (2007): S106-S108.
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Volume
2
Issue
Suppl I
Publish Date
2007
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Immunohistochemical characterization of neuroendocrine cells in prostate cancer

Authors
Huang, J; Yao, JL; di Sant'Agnese, PA; Yang, Q; Bourne, PA; Na, Y
MLA Citation
Huang, J, Yao, JL, di Sant'Agnese, PA, Yang, Q, Bourne, PA, and Na, Y. "Immunohistochemical characterization of neuroendocrine cells in prostate cancer." The Prostate 66.13 (September 15, 2006): 1399-1406.
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66
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2006
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10.1002/pros.20434

Small Cell Carcinoma of the Prostate: An Immunohistochemical Study

Authors
Yao, JL; Madeb, R; Bourne, P; Lei, J; Yang, X; Tickoo, S; Liu, Z; Tan, D; Cheng, L; Hatem, F; Huang, J; Anthony di Sant??Agnese, P
MLA Citation
Yao, JL, Madeb, R, Bourne, P, Lei, J, Yang, X, Tickoo, S, Liu, Z, Tan, D, Cheng, L, Hatem, F, Huang, J, and Anthony di Sant??Agnese, P. "Small Cell Carcinoma of the Prostate: An Immunohistochemical Study." The American Journal of Surgical Pathology 30.6 (June 2006): 705-712.
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Volume
30
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6
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2006
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Early detection and measurement of urothelial tumors in mice

Authors
Johnson, AM; Conover, DL; Huang, J; Messing, EM; Ning, R; O’Connell, MJ; Rossi, MA; Sun, T-T; Wood, RW; Wu, X-R; Reeder, JE
MLA Citation
Johnson, AM, Conover, DL, Huang, J, Messing, EM, Ning, R, O’Connell, MJ, Rossi, MA, Sun, T-T, Wood, RW, Wu, X-R, and Reeder, JE. "Early detection and measurement of urothelial tumors in mice." Urology 67.6 (June 2006): 1309-1314.
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Urology
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67
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2006
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IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SX1

Authors
Sun, Y; Gao, D; Liu, Y; Huang, J; Lessnick, S; Tanaka, S
MLA Citation
Sun, Y, Gao, D, Liu, Y, Huang, J, Lessnick, S, and Tanaka, S. "IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SX1." Oncogene 25 (2006): 1042-1052.
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Oncogene
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2006
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Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma versus cholangiocarcinoma and metastatic carcinoma of the liver

Authors
Lei, J; Bourne, PA; di Sant'Agnese, PA; Huang, J
MLA Citation
Lei, J, Bourne, PA, di Sant'Agnese, PA, and Huang, J. "Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma versus cholangiocarcinoma and metastatic carcinoma of the liver." American Journal of Clinical Pathology 125 (2006): 519-525.
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American Journal of Clinical Pathology
Volume
125
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2006
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525

Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cance

Authors
Wu, C; Zhang, L; Bourne, PA; Reeder, JE; di Sant'Agnese, PA; Yao, JL; Nia, Y; Huang, J
MLA Citation
Wu, C, Zhang, L, Bourne, PA, Reeder, JE, di Sant'Agnese, PA, Yao, JL, Nia, Y, and Huang, J. "Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cance." Prostate 66 (2006): 1125-1135.
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Prostate
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66
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2006
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Expression of p14(ARF), p15(INK4b), p16(INK4a), and DCR2 increases during prostate cancer progression

Authors
Zang, Z; Rosen, DG; Yao, JL; Huang, J; Liu, J
MLA Citation
Zang, Z, Rosen, DG, Yao, JL, Huang, J, and Liu, J. "Expression of p14(ARF), p15(INK4b), p16(INK4a), and DCR2 increases during prostate cancer progression." Modern Pathology 19 (2006): 1339-1343.
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Modern Pathology
Volume
19
Publish Date
2006
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1339
End Page
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Neuroendocrine differentiation in prostate cancer

Authors
Wu, C; Yao, JL; Di Sant'Agnese, PA; Na, Y; Huang, J
MLA Citation
Wu, C, Yao, JL, Di Sant'Agnese, PA, Na, Y, and Huang, J. "Neuroendocrine differentiation in prostate cancer." Zhonghua bing li xue za zhi Chinese journal of pathology 35 (2006): 565-567.
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manual
Published In
Zhonghua bing li xue za zhi Chinese journal of pathology
Volume
35
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2006
Start Page
565
End Page
567

Sonographic features of Biliary Hamartomas with histopathological correlation

Authors
Markhardt, KB; Rubens, DJ; Huang, J; Dogra, VS
MLA Citation
Markhardt, KB, Rubens, DJ, Huang, J, and Dogra, VS. "Sonographic features of Biliary Hamartomas with histopathological correlation." Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 25 (2006): 1631-1633.
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manual
Published In
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
Volume
25
Publish Date
2006
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1631
End Page
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Overexpression of Decoy Receptor 3 in Precancerous Lesions and Adenocarcinoma of the Esophagus

Authors
Li, H; Zhang, L; Lou, H; Ding, I; Kim, S; Wang, L; Huang, J; Di Sant’Agnese, PA; Lei, J-Y
MLA Citation
Li, H, Zhang, L, Lou, H, Ding, I, Kim, S, Wang, L, Huang, J, Di Sant’Agnese, PA, and Lei, J-Y. "Overexpression of Decoy Receptor 3 in Precancerous Lesions and Adenocarcinoma of the Esophagus." American Journal of Clinical Pathology 124.2 (August 2005): 282-287.
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American Journal of Clinical Pathology
Volume
124
Issue
2
Publish Date
2005
Start Page
282
End Page
287
DOI
10.1309/XK594E4B5WU82QR6

Cell Culture Block Array for Immunocytochemical Study of Protein Expression in Cultured Cells

Authors
Li, R; Ni, J; Bourne, PA; Yeh, S; Yao, J; di Sant'Agnese, PA; Huang, J
MLA Citation
Li, R, Ni, J, Bourne, PA, Yeh, S, Yao, J, di Sant'Agnese, PA, and Huang, J. "Cell Culture Block Array for Immunocytochemical Study of Protein Expression in Cultured Cells." Applied Immunohistochemistry & Molecular Morphology 13.1 (March 2005): 85-90.
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Applied Immunohistochemistry and Molecular Morphology
Volume
13
Issue
1
Publish Date
2005
Start Page
85
End Page
90
DOI
10.1097/00129039-200503000-00014

Differential expression of Interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer

Authors
Huang, J; Yao, JL; Zhang, L; Bourne, PA; Quinn, AM; di Sant'Agnese, PA; Reeder, JE
MLA Citation
Huang, J, Yao, JL, Zhang, L, Bourne, PA, Quinn, AM, di Sant'Agnese, PA, and Reeder, JE. "Differential expression of Interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer." American Journal of Pathology 166 (2005): 1807-1815.
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Published In
American Journal of Pathology
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166
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2005
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Neuroendocrine differentiation in prostate cancer

Authors
Huang, J; Wu, C; Yao, JL; di Sant'Agnese, PA
MLA Citation
Huang, J, Wu, C, Yao, JL, and di Sant'Agnese, PA. "Neuroendocrine differentiation in prostate cancer." Ed. BQ Wu. Proceedings of the 4th Asian-Pacific International Academy of Pathology Congress (2005): 57-61.
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Published In
Proceedings of the 4th Asian-Pacific International Academy of Pathology Congress
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2005
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57
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61

Neuroendocrine Differentiation in Prostate Cancer

Authors
Huang, J; Yao, JL; di Sant'Agnese, PA
MLA Citation
Huang, J, Yao, JL, and di Sant'Agnese, PA. "Neuroendocrine Differentiation in Prostate Cancer." Prostate Cancer: Principles and Practice. Ed. R Kirby, AW Partin, M Feneley, and JK Parsons. London, UK: Martin Dunitz Ltd (Taylor & Francis Group), 2005. 143-150. (Chapter)
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2005
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143
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Functional Domain and Motif Analyses of Androgen Receptor Coregulator ARA70 and Its Differential Expression in Prostate Cancer

Authors
Hu, Y-C; Yeh, S; Yeh, S-D; Sampson, ER; Huang, J; Li, P; Hsu, C-L; Ting, H-J; Lin, H-K; Wang, L; Kim, E; Ni, J; Chang, C
MLA Citation
Hu, Y-C, Yeh, S, Yeh, S-D, Sampson, ER, Huang, J, Li, P, Hsu, C-L, Ting, H-J, Lin, H-K, Wang, L, Kim, E, Ni, J, and Chang, C. "Functional Domain and Motif Analyses of Androgen Receptor Coregulator ARA70 and Its Differential Expression in Prostate Cancer." Journal of Biological Chemistry 279.32 (August 6, 2004): 33438-33446.
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The Journal of biological chemistry
Volume
279
Issue
32
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2004
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33438
End Page
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DOI
10.1074/jbc.M401781200

Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma

Authors
Patton, KT; Tretiakova, MS; Yao, JL; Papavero, V; Huo, L; Adley, BP; Wu, G; Huang, J; Pins, MR; Teh, BT; Yang, XJ
MLA Citation
Patton, KT, Tretiakova, MS, Yao, JL, Papavero, V, Huo, L, Adley, BP, Wu, G, Huang, J, Pins, MR, Teh, BT, and Yang, XJ. "Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma." The American Journal of Surgical Pathology 28.8 (August 2004): 1045-1050.
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American Journal of Surgical Pathology
Volume
28
Issue
8
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2004
Start Page
1045
End Page
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DOI
10.1097/01.pas.0000128661.58697.7d

Frequent expression of human carcinoma-associated antigen (HCA), a mucin-type glycoprotein, by cells of prostatic carcinom

Authors
Li, R; Yao, JL; Bourne, PA; di Sant'agnese, PA; Huang, J
MLA Citation
Li, R, Yao, JL, Bourne, PA, di Sant'agnese, PA, and Huang, J. "Frequent expression of human carcinoma-associated antigen (HCA), a mucin-type glycoprotein, by cells of prostatic carcinom." Archives of Pathology & Laboratory Medicine 128 (2004): 1412-1417.
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manual
Published In
Archives of Pathology & Laboratory Medicine
Volume
128
Publish Date
2004
Start Page
1412
End Page
1417

Overexpression of Human Carcinoma-Associated Antigen (HCA) in Urothelial Carcinoma of the Bladder

Authors
Yao, JL; Bourne, PA; Yang, Q; di Sant'Agnese, PA; Huang, J
MLA Citation
Yao, JL, Bourne, PA, Yang, Q, di Sant'Agnese, PA, and Huang, J. "Overexpression of Human Carcinoma-Associated Antigen (HCA) in Urothelial Carcinoma of the Bladder." Archives of Pathology & Laboratory Medicine 128 (2004): 785-787.
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manual
Published In
Archives of Pathology & Laboratory Medicine
Volume
128
Publish Date
2004
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785
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Over-Expression of Human Carcinoma-Associated Antigen in Esophageal Adenocarcinoma and its Precursor Lesions

Authors
Liang, S; Yao, JL; Bourne, PA; di Sant'Agnese, PA; Huang, J; Lei, J
MLA Citation
Liang, S, Yao, JL, Bourne, PA, di Sant'Agnese, PA, Huang, J, and Lei, J. "Over-Expression of Human Carcinoma-Associated Antigen in Esophageal Adenocarcinoma and its Precursor Lesions." American Journal of Clinical Pathology 122 (2004): 747-751.
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manual
Published In
American Journal of Clinical Pathology
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122
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2004
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747
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751

Renal Oncocytosis Presenting in Childhood: A Case Report

Authors
Chen, TS; McNally, M; Hulbert, W; di Sant'Agnese, PA; Huang, J
MLA Citation
Chen, TS, McNally, M, Hulbert, W, di Sant'Agnese, PA, and Huang, J. "Renal Oncocytosis Presenting in Childhood: A Case Report." International Journal of Surgical Pathology 11.4 (October 1, 2003): 325-329.
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International Journal of Surgical Pathology
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11
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4
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2003
Start Page
325
End Page
329
DOI
10.1177/106689690301100415

Vitamin E sccinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery

Authors
Ni, J; Chen, M; Zhang, Y; Li, R; Huang, J; Yeh, S
MLA Citation
Ni, J, Chen, M, Zhang, Y, Li, R, Huang, J, and Yeh, S. "Vitamin E sccinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery." Biochemical and Biophysical Research Communications 300 (2003): 357-363.
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manual
Published In
Biochemical and Biophysical Research Communications
Volume
300
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2003
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357
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363

Human Carcinoma Antigen: A Marker Useful for Discriminating between Benign Prostatic Hyperplasia and Prostate Cancer

Authors
Daiss, J; Carney, J; Cartun, R; Codington, J; Erdrich, C; Hinchman, C; Huang, J; Mauck, J; Schnipelsky, P
MLA Citation
Daiss, J, Carney, J, Cartun, R, Codington, J, Erdrich, C, Hinchman, C, Huang, J, Mauck, J, and Schnipelsky, P. "Human Carcinoma Antigen: A Marker Useful for Discriminating between Benign Prostatic Hyperplasia and Prostate Cancer." Journal of Clinical Ligand Assay 26 (2003): 177-180.
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manual
Published In
Journal of Clinical Ligand Assay
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26
Publish Date
2003
Start Page
177
End Page
180

Clonality of combined tumors: A molecular genetic study

Authors
Huang, J; Behrens, C; Wistuba, II; Gazdar, AF; Jagirdar, J
MLA Citation
Huang, J, Behrens, C, Wistuba, II, Gazdar, AF, and Jagirdar, J. "Clonality of combined tumors: A molecular genetic study." Archives of Pathology & Laboratory Medicine 126 (2002): 437-441.
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manual
Published In
Archives of Pathology & Laboratory Medicine
Volume
126
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2002
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437
End Page
441

Neuroendocrine Differentiation in Prostate Cancer: An Overview

Authors
Huang, J; di Sant' Agnese, PA
MLA Citation
Huang, J, and di Sant' Agnese, PA. "Neuroendocrine Differentiation in Prostate Cancer: An Overview." Advances in Oncology: The Expanding Role of Octreotide I. Ed. SWJ Lamberts and L Dogliotti. Bristol, UK: BioScientifica Ltd, 2002. 243-262. (Chapter)
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manual
Publish Date
2002
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243
End Page
262

Application of flow cytometry in the diagnosis and differential disgnosis of lymphoma and leukemia

Authors
Liu, Z; Huang, J; Yan, Z; Tan, J
MLA Citation
Liu, Z, Huang, J, Yan, Z, and Tan, J. "Application of flow cytometry in the diagnosis and differential disgnosis of lymphoma and leukemia." Zhonghua bing li xue za zhi Chinese journal of pathology 31 (2002): 352-353.
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manual
Published In
Zhonghua bing li xue za zhi Chinese journal of pathology
Volume
31
Publish Date
2002
Start Page
352
End Page
353

Activation of Mitogen-activated Protein Kinase Pathway by the Antiandrogen Hydroxyflutamide in Androgen Receptor-negative Prostate Cancer Cells

Authors
Lee, Y-F; Lin, W-J; Huang, J; Messing, EM; Chan, FL; Wilding, G; Chang, C
MLA Citation
Lee, Y-F, Lin, W-J, Huang, J, Messing, EM, Chan, FL, Wilding, G, and Chang, C. "Activation of Mitogen-activated Protein Kinase Pathway by the Antiandrogen Hydroxyflutamide in Androgen Receptor-negative Prostate Cancer Cells." Cancer Research 62 (2002): 6039-6042.
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manual
Published In
Cancer Research
Volume
62
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2002
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6039
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Molecular analysis of synchronous and metachronous tumors of the lung: Impact on management and prognosis

Authors
Huang, J; Behrens, C; Wistuba, I; Gazdar, AF; Jagirdar, J
MLA Citation
Huang, J, Behrens, C, Wistuba, I, Gazdar, AF, and Jagirdar, J. "Molecular analysis of synchronous and metachronous tumors of the lung: Impact on management and prognosis." Annals of Diagnostic Pathology 5.6 (December 2001): 321-329.
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Annals of Diagnostic Pathology
Volume
5
Issue
6
Publish Date
2001
Start Page
321
End Page
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DOI
10.1053/adpa.2001.29338

Association between initial diagnostic procedure and hysteroscopy and abnormal peritoneal washings in patients with endometrial carcinoma

Authors
Gu, M; Shi, W; Huang, J; Barakat, RR; Thaler, HT; Saigo, PE
MLA Citation
Gu, M, Shi, W, Huang, J, Barakat, RR, Thaler, HT, and Saigo, PE. "Association between initial diagnostic procedure and hysteroscopy and abnormal peritoneal washings in patients with endometrial carcinoma." Cancer 90.3 (June 25, 2000): 143-147.
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90
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2000
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143
End Page
147
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10.1002/1097-0142(20000625)90:3<143::AID-CNCR2>3.0.CO;2-H

Massive Atrial Septal Lipomatous Hypertrophy

Authors
SARIC, MUHAMED; APPLEBAUM, ROBERTM; CULLIFORD, ALFREDT; HUANG, JIAOTI; SCHOLES, JOHNV; KRONZON, ITZHAK
MLA Citation
SARIC, MUHAMED, APPLEBAUM, ROBERTM, CULLIFORD, ALFREDT, HUANG, JIAOTI, SCHOLES, JOHNV, and KRONZON, ITZHAK. "Massive Atrial Septal Lipomatous Hypertrophy." Echocardiography 16.8 (November 1999): 833-834.
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Echocardiography
Volume
16
Issue
8
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1999
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833
End Page
834
DOI
10.1111/j.1540-8175.1999.tb00137.x

Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis

Authors
Huang, J; Mohammadi, M; Rodrigues, GA; Schlessinger, J
MLA Citation
Huang, J, Mohammadi, M, Rodrigues, GA, and Schlessinger, J. "Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis." The Journal of biological chemistry 270 (1995): 5065-5072.
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The Journal of biological chemistry
Volume
270
Publish Date
1995
Start Page
5065
End Page
5072

Activation of human thymocytes induces the phosphorylation of protein tyrosine phosphatase IC

Authors
Trachman, JD; Huang, J; Reem, GH
MLA Citation
Trachman, JD, Huang, J, and Reem, GH. "Activation of human thymocytes induces the phosphorylation of protein tyrosine phosphatase IC." Comptes rendus de l'Académie des Sciences Paris de la vie/Life Sciences 318 (1995): 367-374.
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Comptes rendus de l'Académie des Sciences Paris de la vie/Life Sciences
Volume
318
Publish Date
1995
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367
End Page
374

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

Authors
Spivak-Kroizman, T; Lemmon, MA; Dikic, I; Ladbury, JE; Pinchasi, D; Huang, J; Jaye, M; Crumley, G; Schlessinger, J; Lax, I
MLA Citation
Spivak-Kroizman, T, Lemmon, MA, Dikic, I, Ladbury, JE, Pinchasi, D, Huang, J, Jaye, M, Crumley, G, Schlessinger, J, and Lax, I. "Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation." Cell 79.6 (December 1994): 1015-1024.
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Cell
Volume
79
Issue
6
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1994
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1015
End Page
1024
DOI
10.1016/0092-8674(94)90032-9

Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766

Authors
Huang, J
MLA Citation
Huang, J. "Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766." The Journal of biological chemistry 269 (1994): 17056-17061.
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Published In
The Journal of biological chemistry
Volume
269
Publish Date
1994
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17056
End Page
17061

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

Authors
Vogel, W; Lammers, R; Huang, J; Ullrich, A
MLA Citation
Vogel, W, Lammers, R, Huang, J, and Ullrich, A. "Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation." Science 259.5101 (March 12, 1993): 1611-1614.
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Science
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259
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1993
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DOI
10.1126/science.7681217

The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system

Authors
Levy, JB; Canoll, PD; Silvennoinen, O; Barnea, G; Morse, B; Honegger, AM; Huang, J; Cannizzaro, LA; Park, SH; Druck, T; Huebner, K; Barnea, G; Sap, J; Schlessinger, J
MLA Citation
Levy, JB, Canoll, PD, Silvennoinen, O, Barnea, G, Morse, B, Honegger, AM, Huang, J, Cannizzaro, LA, Park, SH, Druck, T, Huebner, K, Barnea, G, Sap, J, and Schlessinger, J. "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system." The Journal of biological chemistry 268 (1993): 10573-1081.
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Published In
The Journal of biological chemistry
Volume
268
Publish Date
1993
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10573
End Page
1081

Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein

Authors
Huang, J; Schneider, RJ
MLA Citation
Huang, J, and Schneider, RJ. "Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein." Cell 65.2 (April 1991): 271-280.
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Cell
Volume
65
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2
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1991
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271
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280
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10.1016/0092-8674(91)90161-Q

Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex

Authors
Dolph, PJ; Huang, J; Schneider, RJ
MLA Citation
Dolph, PJ, Huang, J, and Schneider, RJ. "Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex." Journal of virology 64 (1990): 2669-2677.
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Published In
Journal of virology
Volume
64
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1990
Start Page
2669
End Page
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Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine

Authors
Huang, J; Schneider, RJ
MLA Citation
Huang, J, and Schneider, RJ. "Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine." Proceedings of the National Academy of Sciences of the United States of America 87.18 (1990): 7115-7119.
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Published In
Proceedings of the National Academy of Sciences of the United States of America
Volume
87
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18
Publish Date
1990
Start Page
7115
End Page
7119

Measurement of estrogen receptor in the nuclei of bone marrow cells of male mice after the administration of estrogen

Authors
Huang, J; Tang, Z
MLA Citation
Huang, J, and Tang, Z. "Measurement of estrogen receptor in the nuclei of bone marrow cells of male mice after the administration of estrogen." Bulletin of the Academy of Military Medical Sciences 2 (1988): 24-26.
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Volume
2
Publish Date
1988
Start Page
24
End Page
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