John Kirkpatrick

Overview:

Malignant and benign tumors of the brain, spine and base of skull. Mathematical modelling of tumor metabolism, mass transfer and the response to ionizing radiation. Enhancing clinical outcome in stereotactic radiosurgery, fractionated stereotactic radiotherapy and stereotactic body radiotherapy.

Positions:

Professor of Radiation Oncology

Radiation Oncology
School of Medicine

Professor in Neurosurgery

Neurosurgery
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

Ph.D. 1978

Rice University

M.D. 1999

University of Texas Health Science Center San Antonio

Grants:

Validation of Novel Therapeutic Approach for Leptomeningeal Metastases

Administered By
Neurosurgery
Role
Investigator
Start Date
End Date

BMX-001 AS A THERAPEUTIC AGENT FOR TREATMENT OF MULTIPLE BRAIN METASTASES

Administered By
Radiation Oncology
Role
Principal Investigator
Start Date
End Date

Publications:

Pineal Parenchymal Tumors of Intermediate Differentiation Treated With Ventricular Radiation and Temozolomide.

Authors
MLA Citation
Low, Justin T., et al. “Pineal Parenchymal Tumors of Intermediate Differentiation Treated With Ventricular Radiation and Temozolomide.Adv Radiat Oncol, vol. 7, no. 1, Jan. 2022, p. 100814. Pubmed, doi:10.1016/j.adro.2021.100814.
URI
https://scholars.duke.edu/individual/pub1500511
PMID
34746517
Source
pubmed
Published In
Advances in Radiation Oncology
Volume
7
Published Date
Start Page
100814
DOI
10.1016/j.adro.2021.100814

Combination laser interstitial thermal therapy plus stereotactic radiotherapy increases time to progression for biopsy-proven recurrent brain metastases.

Background: Improved survival for patients with brain metastases has been accompanied by a rise in tumor recurrence after stereotactic radiotherapy (SRT). Laser interstitial thermal therapy (LITT) has emerged as an effective treatment for SRT failures as an alternative to open resection or repeat SRT. We aimed to evaluate the efficacy of LITT followed by SRT (LITT+SRT) in recurrent brain metastases. Methods: A multicenter, retrospective study was performed of patients who underwent treatment for biopsy-proven brain metastasis recurrence after SRT at an academic medical center. Patients were stratified by "planned LITT+SRT" versus "LITT alone" versus "repeat SRT alone." Index lesion progression was determined by modified Response Assessment in Neuro-Oncology Brain Metastases (RANO-BM) criteria. Results: Fifty-five patients met inclusion criteria, with a median follow-up of 7.3 months (range: 1.0-30.5), age of 60 years (range: 37-86), Karnofsky Performance Status (KPS) of 80 (range: 60-100), and pre-LITT/biopsy contrast-enhancing volume of 5.7 cc (range: 0.7-19.4). Thirty-eight percent of patients underwent LITT+SRT, 45% LITT alone, and 16% SRT alone. Median time to index lesion progression (29.8, 7.5, and 3.7 months [P = .022]) was significantly improved with LITT+SRT. When controlling for age in a multivariate analysis, patients treated with LITT+SRT remained significantly less likely to have index lesion progression (P = .004). Conclusions: These data suggest that LITT+SRT is superior to LITT or repeat SRT alone for treatment of biopsy-proven brain metastasis recurrence after SRT failure. Prospective trials are warranted to validate the efficacy of using combination LITT+SRT for treatment of recurrent brain metastases.
Authors
Grabowski, MM; Srinivasan, ES; Vaios, EJ; Sankey, EW; Otvos, B; Krivosheya, D; Scott, A; Olufawo, M; Ma, J; Fomchenko, EI; Herndon, JE; Kim, AH; Chiang, VL; Chen, CC; Leuthardt, EC; Barnett, GH; Kirkpatrick, JP; Mohammadi, AM; Fecci, PE
MLA Citation
Grabowski, Matthew M., et al. “Combination laser interstitial thermal therapy plus stereotactic radiotherapy increases time to progression for biopsy-proven recurrent brain metastases.Neurooncol Adv, vol. 4, no. 1, Jan. 2022, p. vdac086. Pubmed, doi:10.1093/noajnl/vdac086.
URI
https://scholars.duke.edu/individual/pub1526682
PMID
35795470
Source
pubmed
Published In
Neuro Oncology Advances
Volume
4
Published Date
Start Page
vdac086
DOI
10.1093/noajnl/vdac086

Resolution of radiation necrosis with bevacizumab following radiation therapy for primary CNS lymphoma.

IMPORTANCE: Radiation necrosis (RN) is a rare but serious adverse effect following treatment with radiation therapy. No standard of care exists for the management of RN, and efforts to prevent and treat RN are limited by a lack of insight into the pathomechanics and molecular drivers of RN. This case series describes the outcomes of treatment with bevacizumab (BV) in two primary CNS lymphoma (PCNSL) patients who developed symptomatic biopsy-proven RN after whole brain radiation (WBRT) with a stereotactic radiosurgery (SRS) boost. OBSERVATIONS: Patient 1 is a 52 year-old female with PCNSL treated with WBRT followed by an SRS boost. She developed symptomatic biopsy-proven RN, and initial treatment with tocopherol and pentoxifylline was unsuccessful. A 100% clinical and radiographic response was achieved with 4 cycles of BV. Patient 2, a 48 year-old male with PCNSL, presented with seizures and biopsy-proven RN after radiation therapy. Initial empiric treatment with tocopherol and pentoxifylline was unsuccessful. A 100% clinical and radiographic response was achieved with 3 cycles of BV. CONCLUSIONS AND RELEVANCE: Monitoring for RN in patients with PCNSL treated with radiation therapy is warranted. BV is an efficacious treatment and a viable alternative to corticosteroids or surgical intervention.
Authors
Vaios, EJ; Batich, KA; Buckley, AF; Dunn-Pirio, A; Patel, MP; Kirkpatrick, JP; Goudar, R; Peters, KB
MLA Citation
Vaios, Eugene J., et al. “Resolution of radiation necrosis with bevacizumab following radiation therapy for primary CNS lymphoma.Oncotarget, vol. 13, 2022, pp. 576–82. Pubmed, doi:10.18632/oncotarget.28222.
URI
https://scholars.duke.edu/individual/pub1515399
PMID
35359747
Source
pubmed
Published In
Oncotarget
Volume
13
Published Date
Start Page
576
End Page
582
DOI
10.18632/oncotarget.28222

Analyzing the Usage of Standards in Radiation Therapy Clinical Studies.

Standards for scoring adverse effects after radiation therapy (RT) is crucial for integrated, consistent, and accurate analysis of toxicity results at large scale and across multiple studies. This project aims to investigate the usage of the three most commonly used standards in published RT clinical studies by developing a text-mining based analysis method. We develop and compare two text-mining methods, one based on regular expressions and one based on Naïve Bayes Classifier, to analyze published full articles in terms of their adoption of standards in RT. The full dataset includes published articles identified in MEDLINE between January 2010 and August 2015. A radiation oncology physician reviewed all the articles in the training/validation subset and produced the usage trending data manually as gold standard for validation. The regular-expression based method reported classifications and overall usage trends that are comparable to those of the domain expert. The CTCAE standard is becoming the overall most commonly used standards over time, but the pace of adoption seems very slow. Further examination of the results indicates that the usage vary by disease type. It suggests that further efforts are needed to improve and harmonize the standards for adverse effects scoring in RT research community.
Authors
Zhen, Y; Jiang, Y; Yuan, L; Kirkpartrick, J; Wu, J; Ge, Y
MLA Citation
Zhen, Y., et al. “Analyzing the Usage of Standards in Radiation Therapy Clinical Studies.Ieee Embs Int Conf Biomed Health Inform, vol. 2017, Feb. 2017, pp. 349–52. Pubmed, doi:10.1109/BHI.2017.7897277.
URI
https://scholars.duke.edu/individual/pub1401401
PMID
29707698
Source
pubmed
Published In
Ieee Embs Int Conf Biomed Health Inform
Volume
2017
Published Date
Start Page
349
End Page
352
DOI
10.1109/BHI.2017.7897277

Modification of thermoplastics with styrenic block copolymers

Styrenic block copolymers (SBC) can serve to toughen and/or compatibilize a broad range of plastics. Included among these plastics are polystyrene, polyolefins, polyphenylene ether, polycarbonate, polyamides and polyesters. Selecting the correct SBC polymer to modify a selected plastic or a combination of selected plastics requires an understanding of the complex relationship between SBC structure/composition, plastic composition, blend morphology and processing conditions. This paper presents general concepts and supporting experimental evidence regarding these relationships. Of specific interest is the use of SBC or functionalized SBC (FSBC) to toughen binary polymer blends of SBC and plastic or to toughen and compatibilize blends of SBC with two or more dissimilar plastics.
Authors
Gilmore, DW; Kirkpatrick, JP
MLA Citation
Gilmore, D. W., and J. P. Kirkpatrick. Modification of thermoplastics with styrenic block copolymers. 1990, pp. 43–45.
URI
https://scholars.duke.edu/individual/pub1530521
Source
scopus
Published Date
Start Page
43
End Page
45