Zhao Zhang

Positions:

Assistant Professor of Pharmacology and Cancer Biology

Pharmacology & Cancer Biology
School of Medicine

Member of the Duke Human Vaccine Institute

Duke Human Vaccine Institute
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Affiliate of the Duke Regeneration Center

Regeneration Next Initiative
School of Medicine

Education:

Ph.D. 2013

University of Massachusetts Medical School

Grants:

Training Program in Developmental and Stem Cell Biology

Administered By
Basic Science Departments
Awarded By
National Institutes of Health
Role
Mentor
Start Date
End Date

Somatic transposition-mediated genome variegation during development, disease and aging conditions

Administered By
Pharmacology & Cancer Biology
Awarded By
National Institutes of Health
Role
Principal Investigator
Start Date
End Date

Regulating and harnessing immunity with junk DNA

Administered By
Pharmacology & Cancer Biology
Awarded By
Pew Charitable Trusts
Role
Principal Investigator
Start Date
End Date

Regulation, function, and impact of developmental retrotransposon activation

Administered By
Pharmacology & Cancer Biology
Awarded By
National Institutes of Health
Role
Principal Investigator
Start Date
End Date

Publications:

Developmental retrotransposon activation primes host immunity for future viral-clearance

<jats:title>Abstract</jats:title><jats:p>Transposons are thought to be largely suppressed under physiological conditions, ensuring that their mobilization is a rare event. By tracking mobilization, we show that during metamorphosis at the <jats:italic>Drosophila</jats:italic> pupal stage, the <jats:italic>Gypsy</jats:italic> retrotransposon selectively mobilizes in regenerating tissues. In the newly formed tissues, this wave of <jats:italic>Gypsy</jats:italic> activation primes the host’s innate immune system by inducing the production of <jats:underline>a</jats:underline>nti<jats:underline>m</jats:underline>icrobial <jats:underline>p</jats:underline>eptides (AMPs). Moreover, early immune-priming functions of <jats:italic>Gypsy</jats:italic> are essential for combating viral invasion in adult flies: flies with <jats:italic>Gypsy</jats:italic> being silenced at the pupal stage are unable to clear viruses and succumb to viral infection. Our data reveal that regulated activation of transposons during animal developmental endows a long-term benefit in pathogen warfare.</jats:p>
Authors
Wang, L; Tracy, L; Zhang, ZZZ
MLA Citation
Wang, Lu, et al. Developmental retrotransposon activation primes host immunity for future viral-clearance. Cold Spring Harbor Laboratory. Crossref, doi:10.1101/2020.08.23.263293.
URI
https://scholars.duke.edu/individual/pub1456205
Source
crossref
DOI
10.1101/2020.08.23.263293