The October DCI Seminar Series will be held Wednesday, Oct. 25, at the Great Hall located in the Trent Semans Center. David Christiani, MD, MPH, MS, the Elkan Blout Professor of Environmental Genetics at the Harvard T.H. Chan School of Public Health, Harvard University, will present “Epigenetic modifications of innate immunity genes impact early-stage non-small cell lung cancer survival: An integrative analysis of the epigenome and transcriptome.”
Christiani, who is also professor of medicine at Harvard Medical School, has a major research interest in the interaction between human genes and the environment. Using molecular epidemiology, he studies the impact of humans’ exposure to environmental agents on health, as well as how genetic and acquired susceptibility to these diseases can lead to cancer, acute and chronic pulmonary and cardiovascular diseases. He is also a major contributor to environmental and genetic epidemiology studies internationally.
Working with his research collaborators, Christiani has developed biologic markers for examining pollutant-induced diseases such as lung cancer, bladder cancer, skin cancer, and upper-respiratory-tract inflammation. He has been leading a large molecular and genetic analysis of lung cancer, examining genetic factors that make people susceptible to lung cancer and predicting the outcome of treatment.
A physician in the Pulmonary and Critical Care Unit of Massachusetts General Hospital (MGH), Christiani earned his MD in 1976 from Tufts University, and an MS and MPH from Harvard T.H. Chan School of Public Health. He did his post-graduate medical training at Boston City Hospital and MGH in Boston. At MGH, he leads the Molecular Epidemiology Research Group that conducts research on environmental conditions of the lung, including acute lung injury, lung cancer, and respiratory responses to environmental toxicants.
Christiani has served as an Associate Editor for the Journals Cancer Research and Carcinogenesis, and as a contributing editor to Environmental Health Perspectives, the American Journal of Industrial Medicine and Cancer Medicine. In 2012, President Obama appointed him to a five-year term on the National Cancer Advisory Board. He has authored/co-authored over 600 peer-reviewed publications.
The lecture begins at 8:10 a.m. and ends at 9 a.m. Christiani's address will be preceded by a hematology-oncology fellow presentation starting at 7:30 a.m. The October DCI Seminar Series is presented by the Duke Cancer Institute Cancer Control and Population Sciences Program. Duke Cancer Institute members are invited to attend. For more information, contact Erin Carr.