RTFCCR/LLS Patient-Focused Prevention (2.1.18)

July 14, 2017
By: Julie Poucher Harbin, Writer, DCI

Funding Agency: Leukemia & Lymphoma Society 

The Rising Tide Foundation for Clinical Cancer Research and the Leukemia & Lymphoma Society are partnering once again to launch an international competitive grant to advance breakthroughs in prevention for blood cancers. The grant is focused on addressing four critical topics and is endowed with a total of USD $3 million; 3-5 grants will be awarded ranging from $0.6 – 1.2 M each.

The grants must be translational in nature. Ideally, the applications will have a clinical trial proposed, or could lead to a clinical trial. Applications that are solely laboratory-based without consideration of using patient samples or future clinical testing will not be accepted for review.

Areas of Interest: 

RFP Suggested Topics:

  • Clinical Trials: Examine the use of pharmaceuticals, nutraceuticals, or life-style changes as prevention of blood cancer onset, progression to full blown disease, or relapse. Applications could be for any premalignant conditions before the onset of blood cancer or after successful blood cancer therapy (i.e. prevention of relapse). Therapeutics could include small molecules, biologics, or immunotherapeutics.
  • Biomarker evaluation: Develop and apply sensitive minimally invasive methods to detect precursor conditions before disease onset or sustained after successful therapy
  • Use experimental systems to identify safe and effective therapeutic strategies to eliminate mutant clones early in disease stages or prevent recurrence of disease that could justify a clinical trial in prevention
  • Drug the undruggable: Develop novel strategies to remove / deactivate tumor drivers that initiate, or predispose to, disease onset and/or develop novel approaches, such as synthetic lethality, to achieve the same goal.

Funding Amount: 

The amount of each award is based on the availability of funds. The duration of the award is up to five years or less as specified in the grant award letter. Rising Tide will disburse awarded funds only if the recipient maintains strict compliance with reporting and participant accrual requirements as outlined in Rising Tide’s Research Funding Terms and Conditions. 

Application Deadlines:  

  • Letter of Intent: Oct. 1, 2017
  • Invited Application: Feb. 1, 2018

Eligibility: Faculty

For more information: https://www.lls.org/research/rtfccrlls-patient-focused-prevention