Matthew J. Ellis, BSC, MS, BCHIR, PhD, FRCP, director of the Lester and Sue Smith Breast Cancer Center, Baylor College of Medicine, will speak at the January DCI Seminar.
Ellis has been instrumental in developing a Genome Atlas and Therapeutic Road Map for estrogen receptor positive breast cancer by applying genomic techniques to samples accrued through a series of neoadjuvant endocrine therapy trials. Most recently, he discovered that metastatic breast tumors harbor mutations and translocations in the estrogen receptor gene that render the tumor resistant to therapies used to block estrogen receptor function. Ellis pioneered research into the clinical relevance of activating mutations in HER2 and in the deployment of patient-derived xenografts for the pharmacological annotation of breast cancer genomes.
The DCI Seminar Series lecture will be held on Wednesday, Jan. 27, in the Trent Semans Center, Great Hall. The lecture begins at 8:10 a.m. and ends at 9 a.m. Ellis' address will be preceded by a hematology-oncology fellow presentation starting at 7:30 a.m. All are invited to attend. For more information, contact Erin Carr.