On Wednesday, April 27, Paul S. Frenette, MD, director and chair, The Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine of Yeshiva University, will present “Understanding the complexity of hematopoietic stem cell microenvironment.”
Frenette's laboratory is interested in understanding how hematopoietic stem cells (HSCs) and mature blood cells traffic in vivo. Frenette has uncovered a key role for the nervous system in regulating HSC trafficking, and is evaluating its role in the inflammatory response in diseases such as sickle cell disease. He is also exploring whether the traffic paradigms uncovered for healthy stem cells applies to cancer cell migration and metastasis. The Frenette lab is also exploring the role of the autonomic nervous system in cancer formation and metastasis using xenogeneic and transgenic models of prostate cancer. These studies have led to the indeitification of novel functions for the sympathetic (adrenergic) and parasympathetic (cholinergic) nervous system in the initiation and metastasis, respectively, of prostate cancer. Further studies will analyze in more detail the mechanisms and to obtain new insight on the cellular and molecular cues that regulate the tumour microenvironment and allow cancer cells to spread.
The DCI Seminar Series lecture will be held on Wednesday, April 27, in the Trent Semans Center, Great Hall. The lecture begins at 8:10 a.m. and ends at 9 a.m. Frenette's address will be preceded by a hematology-oncology fellow presentation starting at 7:30 a.m. All are invited to attend. For more information, contact Erin Carr.