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PK/PD Bioanalytical Core Lab
Leadership
Ivan Spasojevic, PhD
ivan.spasojevic@duke.edu
919-684-8311
Neil Spector, MD
neil.spector@duke.edu
919-681-4699
Location
5317 Orange Zone
Resource Overview
PK/PD Bioanalytical Core Laboratory provides quality, timely, and cost-effective analysis of low-molecular-weight molecules, e.g. drugs, metabolites, and biomarkers in bodily fluids, tissues, and cell culture media for cancer-related projects spanning from preclinical animal and in vitro studies to Phase I and II clinical trials. The lab activities include: study design, sample collection/processing/storage, quantitative analysis, as well as PK/PD non-compartmental and compartmental data analysis (WinNonlin) and data interpretation.
The facility is equipped with state-of-the-art instrumentation for analysis of low molecular weight molecules: Three industry-standard liquid chromatography – tandem mass spectrometry (LC-MS/MS) systems (Applied Biosystems API 4000 QTrap, API 4000 3Q, and API 3200 QTrap MS/MS spectrometers with Shimadzu 20A and Agilent 1100/1200 HPLC stacks), two HPLC-UV/vis/fluorescence systems (Waters 2695 modules and 2487 UV/vis, 996 PDA uv/vis, and 2475 fluorescence detectors) and one GC/MS (Agilent 6890 GC oven with 5973 EI-MS detector). Specialized detectors include: Laser-Induced-Fluorescence (Picometrics, LIF detector and dye-laser), and Electrochemical detector (B.A.S.).
All investigators involved closely or remotely in cancer research where a measurement of low-molecular-weight analytes is needed are encouraged to use the resource.
Call Dr. Ivan Spasojevic at 919-684-8311 or e-mail ivan.spasojevic@dm.duke.edu to set up a meeting and discuss the service/consultation needs, feasibility and timeline.
