SPARC: Prostatectomy +/- Cabozantinib in High-Risk Prostate Cancer Patients

What is the Purpose of this Study?

If you choose to join this study, you will:
- Have blood and urine tests
- Be randomly assigned to one of two groups:
-- Group A will take cabozantinib (a pill that you take by mouth) every day for 4 weeks before having surgery to remove their prostate
-- Group B will have a surgery to remove their prostate immediately
What is the Condition Being Studied?
Untreated, High-Risk Prostate Cancer

Who Can Participate in this Study?

Adults with prostate cancer who:

- Plan to have a surgery called a radical prostatectomy

- Have not had any previous treatments for their cancer

Age Group
Participating Institutions

What is Involved?

We are doing this study to learn how effective cabozantinib is at killing prostate cancer cells.

Another purpose of the study is to learn if there is a difference in how often cancer comes back in people who take cabozantinib before having surgery to remove their prostate compared to people who have surgery right away.

Study Details

Full Title
A Phase II, Open-Label Randomized Study of Immediate Prostatectomy vs. Cabozantinib Followed by Prostatectomy in Men with High-Risk Prostate Cancer (SPARC)
Principal Investigator

Protocol Number

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