Hematologic Malignancies & Cellular Therapy


Overview & Treatment

GoodeAs leaders in hematologic oncology, stem cell and bone marrow transplantation, and immunotherapy, Duke Cancer Institute’s Hematologic Malignancies and Cellular Therapy (HMCT) disease group is internationally recognized for its novel approaches to treating leukemia, lymphoma, myeloma and other life threatening blood-related cancers.

We promote health and improve lives by preventing, diagnosing and treating blood cancers through integrated, innovative, and holistic patient care, education and research.

We offer a  broad selection of treatment options, including access to national and investigator-initiated clinical trials.

More Information

Make An Appointment

Duke Hematologic Malignancies & Cellular Therapy specialists provide comprehensive, multidisciplinary care for patients at the Duke Cancer Center and the Duke Adult Blood & Marrow Transplant Clinic.

To make an appointment, please call 919.684.8964.

Providers who see patients in the Hematologic Malignancies Clinic include Carlos DeCastroJoseph MooreThomas LeblancMatthew McKinneyLindsay ReinAhmed Galal, and Alexandra Stefanovic.

Providers who see patients in the ABMT Clinic include Mitchell HorwitzNelson ChaoGwynn LongCristina GasparettoYubin KangAnthony SungStefanie SarantopoulosTaewoong Choi, and Cristiana Costa.

Find A Specialist


The Duke Hematologic Malignancies & Cellular Therapy (HMCT) Program is a multidisciplinary basic, translational, and clinical research program whose overall goal is to improve outcomes for patients with hematologic malignancies.

Our research program can be broadly divided into the following research areas: 

  • Basic research into the tumor microenvironment, bone marrow niche
  • Basic understanding of immunity, both inate and adaptive
  • Genomics, including a genomics core
  • Cellular therapies such as hematopoietic stem cells, adoptive immunotherapy with selected T cells, NK cells, dendritic cell vaccines, gamma delta T cells
  • Graft-versus-host disease and graft-versus-leukemia effects
  • Cell signaling pathways in normal and tumor cells

Clinical Trials

We offer our patients access to more than 50 active clinical trials specific to hematologic malignancies and transplantation.

These trials range from securely storing your medical information in an outcomes-reporting registry, to sample repositories, and to national clinical trials and investigator-initiated trials designed to prevent, detect, or treat your underlying disease with the most advanced treatment methods.

Your participation may help you and others in the future. 

Some of these trials are only offered at the Duke Cancer Institute. As a result, we offer a broad selection of treatment options to our patients, including some who are not considered candidates for treatment elsewhere. Your participation in a clinical trial may help you and others in the future. 


Additional Contacts

Jacob Keller, MHA, Administrative Director
Phone: 919.660.3233

Gabriel Alcantara, MBA, HMCT Division Administrator
Phone: 919.668.2121

Peggy Alton, RN, BSN Assistant Research Practice Manager
Phone: 919.668.1016