Karl-Dimiter Bissig
Overview:
Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.
Positions:
Chen Family Associate Professor of Pediatrics
Pediatrics, Medical Genetics
School of Medicine
Associate Professor in Pediatrics
Pediatrics, Medical Genetics
School of Medicine
Associate Professor of Biomedical Engineering
Biomedical Engineering
Pratt School of Engineering
Associate Professor in Pharmacology and Cancer Biology
Pharmacology & Cancer Biology
School of Medicine
Member of the Duke Cancer Institute
Duke Cancer Institute
School of Medicine
Affiliate of the Duke Regeneration Center
Regeneration Next Initiative
School of Medicine
Education:
MD./PhD. 2000
Universitat Bern (Switzerland)
Residency, Internal Medicine
Inselspital (Switzerland)
Postdoctoral Fellow
Salk Institute for Biological Studies
Grants:
Physiological Dissection of the Mevalonate Pathway
Administered By
Pediatrics, Medical Genetics
Awarded By
Baylor College of Medicine
Role
Principal Investigator
Start Date
End Date
Therapeutic pathway reprogramming for metabolic liver disease
Administered By
Pediatrics, Medical Genetics
Awarded By
National Institutes of Health
Role
Principal Investigator
Start Date
End Date
Therapeutic pathway reprogramming for metabolic liver disease
Administered By
Pediatrics, Medical Genetics
Awarded By
National Institutes of Health
Role
Principal Investigator
Start Date
End Date
Therapeutic potential of CRISPR/Cas9 genome engineering in humanized mouse
Administered By
Pediatrics, Medical Genetics
Awarded By
National Institutes of Health
Role
Principal Investigator
Start Date
End Date
Physiological Dissection of the Mevalonate Pathway
Administered By
Pediatrics, Medical Genetics
Awarded By
Baylor College of Medicine
Role
Principal Investigator
Start Date
End Date
Research Areas:
Muser Mentor
Chen Family Associate Professor of Pediatrics