Laura Havrilesky
Overview:
I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer. The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women.
Positions:
Professor of Obstetrics and Gynecology
Obstetrics and Gynecology, Gynecologic Oncology
School of Medicine
Professor in Population Health Sciences
Population Health Sciences
School of Medicine
Member of the Duke Cancer Institute
Duke Cancer Institute
School of Medicine
Education:
M.D. 1995
Duke University
Residency, Obstetrics And Gynecology
Duke University
Gynecology Oncology Fellowship, Obstetrics And Gynecology
Duke University School of Medicine
Grants:
Tissue and Data Acquisition Activity for the Study of Gynecologic Disease
Administered By
Obstetrics and Gynecology, Gynecologic Oncology
Awarded By
United States Army Medical Research and Materiel Command
Role
Principal Investigator
Start Date
End Date
Tissue and Data Acquisition Activity for the Study of Gynecologic Disease
Administered By
Obstetrics and Gynecology, Gynecologic Oncology
Role
Principal Investigator
Start Date
End Date
Ovarian Cancer Patient-Centered Decision Aid
Administered By
Obstetrics and Gynecology, Gynecologic Oncology
Awarded By
University of California - Irvine
Role
Principal Investigator
Start Date
End Date
Tissue and Data Acquisition Activity for the Study of Gynecologic Disease
Administered By
Obstetrics and Gynecology, Gynecologic Oncology
Awarded By
Henry M. Jackson Foundation
Role
Principal Investigator
Start Date
End Date
Intraluminal tumor cells and endometrial cancer prognosis
Administered By
Obstetrics and Gynecology, Gynecologic Oncology
Awarded By
Ohio State University
Role
Principal Investigator
Start Date
End Date
Publications:
Universal Screening for Lynch Syndrome in Uterine Cancer Patients: A Quality Improvement Initiative
Authors
Spinosa, D; Acosta, T; Wong, J; Kurtovic, K; Mewshaw, J; Collins, S; Kauff, N; Havrilesky, LJ; Strickland, KC; Previs, RA
MLA Citation
Spinosa, D., et al. “Universal Screening for Lynch Syndrome in Uterine Cancer Patients: A Quality Improvement Initiative.” Obstetrical and Gynecological Survey, vol. 76, no. 4, Apr. 2021, pp. 203–05. Scopus, doi:10.1097/01.ogx.0000742224.68804.f6.
URI
https://scholars.duke.edu/individual/pub1583614
Source
scopus
Published In
Obstetrical & Gynecological Survey
Volume
76
Published Date
Start Page
203
End Page
205
DOI
10.1097/01.ogx.0000742224.68804.f6
Malnutrition as a Risk Factor for Post-Operative Morbidity in Gynecologic Cancer: Analysis Using a National Surgical Outcomes Database
Authors
MLA Citation
Goins, E. C., et al. “Malnutrition as a Risk Factor for Post-Operative Morbidity in Gynecologic Cancer: Analysis Using a National Surgical Outcomes Database.” Obstetrical and Gynecological Survey, vol. 77, no. 7, July 2022, pp. 407–09. Scopus, doi:10.1097/OGX.0000000000001057.
URI
https://scholars.duke.edu/individual/pub1583991
Source
scopus
Published In
Obstetrical & Gynecological Survey
Volume
77
Published Date
Start Page
407
End Page
409
DOI
10.1097/OGX.0000000000001057
Guidelines for goals of care discussions in patients with gynecologic cancer.
This article represents a distillation of literature to provide guidance for goals of care discussions with patients who have gynecologic malignancies. As clinicians who provide surgical care, chemotherapy, and targeted therapeutics, gynecologic oncology clinicians are uniquely positioned to form longitudinal relationships with patients that can enable patient-centered decision making. In this review, we describe optimal timing, components, and best practices for goals of care discussions in gynecologic oncology.
Authors
MLA Citation
Peters, Pamela N., et al. “Guidelines for goals of care discussions in patients with gynecologic cancer.” Gynecol Oncol, vol. 174, July 2023, pp. 247–52. Pubmed, doi:10.1016/j.ygyno.2023.05.016.
URI
https://scholars.duke.edu/individual/pub1579827
PMID
37243995
Source
pubmed
Published In
Gynecol Oncol
Volume
174
Published Date
Start Page
247
End Page
252
DOI
10.1016/j.ygyno.2023.05.016
Geographic variation in the rate and route of hysterectomy for benign disease in the USA: A retrospective cross-sectional study.
OBJECTIVES: To describe population rate of hysterectomy for benign disease in the USA, including geographic variation across states and Hospital Service Areas (HSAs; areas defined by common patient flows to healthcare facilities). DESIGN: Cross-sectional study. SETTING: Four US states including 322 HSAs. POPULATION: A total of 316 052 cases of hysterectomy from 2012 to 2016. METHODS: We compiled annual hysterectomy cases, merged female populations, and adjusted for reported rates of previous hysterectomy. We assessed small-area variation and created multi-level Poisson regression models. MAIN OUTCOME MEASURES: Prior-hysterectomy-adjusted population rates of hysterectomy for benign disease. RESULTS: The annual population rate of hysterectomy for benign disease was 49 per 10 000 hysterectomy-eligible residents, declining slightly over time, mostly among reproductive-age populations. Rates peaked among residents ages 40-49 years, and declined with increasing age, apart from an increase with universal coverage at age 65 years. We found large differences in age-standardised population rates of hysterectomy across states (range 42.2-69.0), and HSAs (range: overall 12.9-106.3; 25th-75th percentile 44.0-64.9). Among the non-elderly population, those with government-sponsored insurance had greater variation than those with private insurance (coefficient of variation 0.61 versus 0.32). Proportions of minimally invasive procedures were similar across states (71.0-74.8%) but varied greatly across HSAs (27-96%). In regression models, HSA population characteristics explained 31.8% of observed variation in annual rates. Higher local proportions of government-sponsored insurance and non-White race were associated with lower population rates. CONCLUSIONS: We found substantial variation in rate and route of hysterectomy for benign disease in the USA. Local population characteristics explained less than one-third of observed variation.
Authors
MLA Citation
Albright, Benjamin B., et al. “Geographic variation in the rate and route of hysterectomy for benign disease in the USA: A retrospective cross-sectional study.” Bjog, May 2023. Pubmed, doi:10.1111/1471-0528.17509.
URI
https://scholars.duke.edu/individual/pub1575134
PMID
37132056
Source
pubmed
Published In
Bjog
Published Date
DOI
10.1111/1471-0528.17509
An obstetrician-gynecologist's review of hernias: risk factors, diagnosis, prevention, and repair.
Management of obstetrical and gynecologic patients with hernias poses challenges to providers. Risks for hernia development include well-described factors that impair surgical wound healing and increase abdominal pressure. Among the diverse populations cared for by obstetricians and gynecologists, pregnant patients and those with gynecologic malignancies are at the highest risk for hernia formation. This article provides an overview of the existing literature, with a focus on patients cared for by obstetrician-gynecologists and commonly encountered preoperative and intraoperative scenarios. We highlight scenarios when a hernia repair is not commonly performed, including those of patients undergoing nonelective surgeries with known or suspected gynecologic cancers. Finally, we offer multidisciplinary recommendations on the timing of elective hernia repair with obstetrical and gynecologic procedures, with attention to the primary surgical procedure, the type of preexisting hernia, and patient characteristics.
Authors
MLA Citation
Knochenhauer, Hope E., et al. “An obstetrician-gynecologist's review of hernias: risk factors, diagnosis, prevention, and repair.” Am J Obstet Gynecol, Apr. 2023. Pubmed, doi:10.1016/j.ajog.2023.04.024.
URI
https://scholars.duke.edu/individual/pub1575708
PMID
37120051
Source
pubmed
Published In
American Journal of Obstetrics and Gynecology
Published Date
DOI
10.1016/j.ajog.2023.04.024

Professor of Obstetrics and Gynecology
Contact:
25172 Morris Bldg, Durham, NC 27710
Box 3079 Med Ctr, Durham, NC 27710