Sin-Ho Jung
Overview:
Design of Clinical Trials
Survival Analysis
Longitudinal Data Analysis
Clustered Data Analysis
ROC Curve Analysis
Design and Analysis of Microarray Studies
Big Data Analysis
Survival Analysis
Longitudinal Data Analysis
Clustered Data Analysis
ROC Curve Analysis
Design and Analysis of Microarray Studies
Big Data Analysis
Positions:
Professor of Biostatistics & Bioinformatics
Integrative Genomics
School of Medicine
Member of the Duke Cancer Institute
Duke Cancer Institute
School of Medicine
Education:
Ph.D. 1992
University of Wisconsin - Madison
Grants:
Dissecting Mechanisms by which p53 Suppresses Transformation and Radiation Carcinogenesis
Administered By
Radiation Oncology
Awarded By
National Institutes of Health
Role
Co Investigator
Start Date
End Date
Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities
Administered By
Medicine, Medical Oncology
Awarded By
National Institutes of Health
Role
Biostatistician
Start Date
End Date
Alliance NCORP Research Base - Clinical Trials - CALGB 70807
Administered By
Duke Cancer Institute
Awarded By
Mayo Clinic
Role
Principal Investigator
Start Date
End Date
ETIOLOGY OF COPD AMONG CONSTRUCTION WORKERS
Administered By
Family Medicine & Community Health,Occupational & Environmental Medicine
Awarded By
National Institute for Occupational Safety and Health
Role
Biostatistician
Start Date
End Date
Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities
Administered By
Medicine, Medical Oncology
Awarded By
National Institutes of Health
Role
Biostatistician
Start Date
End Date
Publications:
Regional anesthesia is associated with improved metastasis free survival after surgical resection of bone sarcomas.
There is increasing evidence that perioperative factors, including type of anesthesia, may be an important consideration regarding oncological disease progression. Previous studies have suggested that regional anesthesia can improve oncological outcomes by reducing the surgical stress response that occurs during tumor resection surgery and that may promote metastatic progression. The purpose of this study is to provide the first robust investigation of the impact of adding regional anesthesia to general anesthesia on oncological outcomes following sarcoma resection. One hundred patients with bone sarcoma were retrospectively analyzed in this study. After adjusting for confounding variables such as age and grade of the tumor, patients with bone sarcoma receiving regional anesthesia in addition to general anesthesia during resection had improved metastasis free survival (multivariate hazard ratio of 0.47 and p = 0.034). Future studies are needed to confer the beneficial effect of regional anesthesia, and to further investigate the potential mechanism. Clinical significance: The results from this study provide evidence that regional anesthesia may be advantageous in the setting of bone sarcoma resection surgery, reducing pain while also improving oncological outcomes and should be considered when clinically appropriate.
Authors
Abar, B; Gao, J; Fletcher, AN; Sachs, E; Wong, AH; Lazarides, AL; Okafor, C; Brigman, BE; Eward, WC; Jung, S-H; Kumar, AH; Visgauss, JD
MLA Citation
Abar, Bijan, et al. “Regional anesthesia is associated with improved metastasis free survival after surgical resection of bone sarcomas.” J Orthop Res, May 2023. Pubmed, doi:10.1002/jor.25597.
URI
https://scholars.duke.edu/individual/pub1575442
PMID
37151123
Source
pubmed
Published In
J Orthop Res
Published Date
DOI
10.1002/jor.25597
Quantifying the Opportunity Cost of Neurosurgical Resident Education.
BACKGROUND/OBJECTIVE: Education is at the core of neurosurgical residency, but little research in to the cost of neurosurgical education exists. This study aimed to quantify costs of resident education in an academic neurosurgery program using traditional teaching methods and the Surgical Autonomy Program (SAP), a structured training program. METHODS: SAP assesses autonomy by categorizing cases into zones of proximal development (opening, exposure, key section, and closing). All first-time, 1-level to 4-level anterior cervical discectomy and fusion (ACDF) cases between March 2014 and March 2022 from 1 attending surgeon were divided into 3 groups: independent cases, cases with traditional resident teaching, and cases with SAP teaching. Surgical times for all cases were collected and compared within levels of surgery between groups. RESULTS: The study found 2140 ACDF cases, with 1758 independent, 223 with traditional teaching, and 159 with SAP. For 1-level to 4-level ACDFs, teaching took longer than it did with independent cases, with SAP teaching adding additional time. A 1-level ACDF performed with a resident (100.1 ± 24.3 minutes) took about as long as a 3-level ACDF performed independently (97.1 ± 8.9 minutes). The average time for 2-level cases was 72.0 ± 18.2 minutes independently, 121.7 ± 33.7 minutes traditional, and 143.4 ± 34.9 minutes SAP, with significant differences among all groups. CONCLUSIONS: Teaching takes significant time compared with operating independently. There is also a financial cost to educating residents, because operating room time is expensive. Because attending neurosurgeons lose time to perform more surgeries when teaching residents, there is a need to acknowledge surgeons who devote time to training the next generation of neurosurgeons.
Authors
Venkatraman, V; Suarez, AD; Kirsch, EP; Heo, H; Wu, KA; McDaniel, KE; Yang, LZ; Jung, S-H; Dharmapurikar, R; Lad, SP; Haglund, MM
MLA Citation
Venkatraman, Vishal, et al. “Quantifying the Opportunity Cost of Neurosurgical Resident Education.” World Neurosurg, Apr. 2023. Pubmed, doi:10.1016/j.wneu.2023.04.005.
URI
https://scholars.duke.edu/individual/pub1571833
PMID
37030478
Source
pubmed
Published In
World Neurosurg
Published Date
DOI
10.1016/j.wneu.2023.04.005
Revisiting flow augmentation bypass for cerebrovascular atherosclerotic vaso-occlusive disease: Single-surgeon series and review of the literature.
OBJECTIVE: Despite advances in the nonsurgical management of cerebrovascular atherosclerotic steno-occlusive disease, approximately 15-20% of patients remain at high risk for recurrent ischemia. The benefit of revascularization with flow augmentation bypass has been demonstrated in studies of Moyamoya vasculopathy. Unfortunately, there are mixed results for the use of flow augmentation in atherosclerotic cerebrovascular disease. We conducted a study to examine the efficacy and long term outcomes of superficial temporal artery to middle cerebral artery (STA-MCA) bypass in patients with recurrent ischemia despite optimal medical management. METHODS: A single-institution retrospective review of patients receiving flow augmentation bypass from 2013-2021 was conducted. Patients with non-Moyamoya vaso-occlusive disease (VOD) who had continued ischemic symptoms or strokes despite best medical management were included. The primary outcome was time to post-operative stroke. Time from cerebrovascular accident to surgery, complications, imaging results, and modified Rankin Scale (mRS) scores were aggregated. RESULTS: Twenty patients met inclusion criteria. The median time from cerebrovascular accident to surgery was 87 (28-105.0) days. Only one patient (5%) had a stroke at 66 days post-op. One (5%) patient had a post-operative scalp infection, while 3 (15%) developed post-operative seizures. All 20 (100%) bypasses remained patent at follow-up. The median mRS score at follow up was significantly improved from presentation from 2.5 (1-3) to 1 (0-2), P = .013. CONCLUSIONS: For patients with high-risk non-Moyamoya VOD who have failed optimal medical therapy, contemporary approaches to flow augmentation with STA-MCA bypass may prevent future ischemic events with a low complication rate.
Authors
MLA Citation
Abdelgadir, Jihad, et al. “Revisiting flow augmentation bypass for cerebrovascular atherosclerotic vaso-occlusive disease: Single-surgeon series and review of the literature.” Plos One, vol. 18, no. 5, 2023, p. e0285982. Pubmed, doi:10.1371/journal.pone.0285982.
URI
https://scholars.duke.edu/individual/pub1578197
PMID
37205640
Source
pubmed
Published In
Plos One
Volume
18
Published Date
Start Page
e0285982
DOI
10.1371/journal.pone.0285982
Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma.
This study aims to investigate whether adding neoadjuvant radiotherapy (RT), anti-programmed cell death protein-1 (PD-1) antibody (anti-PD-1), or RT + anti-PD-1 to surgical resection improves disease-free survival for mice with soft tissue sarcomas (STS). We generated a high mutational load primary mouse model of STS by intramuscular injection of adenovirus expressing Cas9 and guide RNA targeting Trp53 and intramuscular injection of 3-methylcholanthrene (MCA) into the gastrocnemius muscle of wild-type mice (p53/MCA model). We randomized tumor-bearing mice to receive isotype control or anti-PD-1 antibody with or without radiotherapy (20 Gy), followed by hind limb amputation. We used micro-CT to detect lung metastases with high spatial resolution, which was confirmed by histology. We investigated whether sarcoma metastasis was regulated by immunosurveillance by lymphocytes or tumor cell-intrinsic mechanisms. Compared with surgery with isotype control antibody, the combination of anti-PD-1, radiotherapy, and surgery improved local recurrence-free survival (P = 0.035) and disease-free survival (P = 0.005), but not metastasis-free survival. Mice treated with radiotherapy, but not anti-PD-1, showed significantly improved local recurrence-free survival and metastasis-free survival over surgery alone (P = 0.043 and P = 0.007, respectively). The overall metastasis rate was low (∼12%) in the p53/MCA sarcoma model, which limited the power to detect further improvement in metastasis-free survival with addition of anti-PD-1 therapy. Tail vein injections of sarcoma cells into immunocompetent mice suggested that impaired metastasis was due to inability of sarcoma cells to grow in the lungs rather than a consequence of immunosurveillance. In conclusion, neoadjuvant radiotherapy improves metastasis-free survival after surgery in a primary model of STS.
Authors
Patel, R; Mowery, YM; Qi, Y; Bassil, AM; Holbrook, M; Xu, ES; Hong, CS; Himes, JE; Williams, NT; Everitt, J; Ma, Y; Luo, L; Selitsky, SR; Modliszewski, JL; Gao, J; Jung, S-H; Kirsch, DG; Badea, CT
MLA Citation
Patel, Rutulkumar, et al. “Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma.” Mol Cancer Ther, vol. 22, no. 1, Jan. 2023, pp. 112–22. Pubmed, doi:10.1158/1535-7163.MCT-21-0991.
URI
https://scholars.duke.edu/individual/pub1550806
PMID
36162051
Source
pubmed
Published In
Mol Cancer Ther
Volume
22
Published Date
Start Page
112
End Page
122
DOI
10.1158/1535-7163.MCT-21-0991
Improved survival of multiple vs single primary melanomas
Authors
MLA Citation
Sarver, M. M., et al. “Improved survival of multiple vs single primary melanomas.” Journal of Investigative Dermatology, vol. 142, no. 8, 2022, pp. S32–S32.
URI
https://scholars.duke.edu/individual/pub1547616
Source
wos-lite
Published In
Journal of Investigative Dermatology
Volume
142
Published Date
Start Page
S32
End Page
S32

Professor of Biostatistics & Bioinformatics
Contact:
2424 Erwin Road Ste 1102, 11076 Hock Plaza, Durham, NC 27705-3858
Duke Box 2721, Durham, NC 27710