cancer resistance

A team led by Duke biochemistry professor Bruce Donald, PhD, has developed an algorithm to predict how mutations in an enzyme will affect a drug’s efficacy.

The research team found a signaling pathway within melanoma and other cancers that thwart the functioning of anti-PD-1 checkpoint inhibitors.

Kris Wood, PhD, and team, are investigating how to turn a tumor’s strength – its drug resistance – into a weakness. This research was published in Nature Genetics.

Duke Alumnus, Trustee William G. Kaelin Jr., MD, shares award for studies of how cells adapt to changing oxygen environments. Sign-up for October 16 web chat with him.