Edward Levin
Professor in Psychiatry and Behavioral Sciences
Overview
Dr. Levin is Chief of the Neurobehavioral Research Lab in the Psychiatry Department of Duke University Medical Center. His primary academic appointment is as Professor in the Department of Psychiatry and Behavioral Sciences. He also has secondary appointments in the Department Pharmacology and Cancer Biology, the Department of Psychological and Brain Sciences and the Nicholas School of the Environment at Duke. His primary research effort is to understand basic neural interactions underlying cognitive function and addiction and to apply this knowledge to better understand cognitive dysfunction and addiction disorders and to develop novel therapeutic treatments.
The three main research components of his laboratory are focused on the themes of the basic neurobiology of cognition and addiction, neurobehavioral toxicology and the development of novel therapeutic treatments for cognitive dysfunction and substance abuse. Currently, our principal research focus concerns nicotine. We have documented the basic effects of nicotine on learning memory and attention as well as nicotine self-administration. We are continuing with more mechanistic studies in rat models using selective lesions, local infusions and neurotransmitter interaction studies. We have found that nicotine improves memory performance not only in normal rats, but also in rats with lesions of hippocampal and basal forebrain connections. We are concentrating on alpha7 and alpha4beta2 nicotinic receptor subtypes in the hippocampus, amygdala , thalamus and frontal cortex and how they interact with dopamine D1 and D2 and glutamate NMDA systems with regard to memory and addiction. I am also conducting studies on human cognitive behavior. We have current studies to assess nicotine effects on attention, memory and mental processing speed in schizophrenia, Alzheimer's Disease and Attention Deficit Hyperactivity Disorder. In the area of neurobehavioral toxicology, I have continuing projects to characterize the adverse effects of prenatal and adolescent nicotine exposure. Our primary project in neurobehavioral toxicology focuses on the cognitive deficits caused by the marine toxins. The basic and applied aims of our research complement each other nicely. The findings concerning neural mechanisms underlying cognitive function help direct the behavioral toxicology and therapeutic development studies, while the applied studies provide important functional information concerning the importance of the basic mechanisms under investigation.
Positions
Professor in Psychiatry and Behavioral Sciences in the School of Medicine
2021 School of Medicine
Director, Integrated Toxicology Program in the School of Medicine
1995 School of Medicine
Professor in the Environmental Sciences and Policy Division in the Nicholas School of the Environment
2015 Nicholas School of the Environment
Associate Professor of Pharmacology & Cancer Biology in the School of Medicine
1998 School of Medicine
Professor of Psychology and Neuroscience in the Trinity College of Arts & Sciences
2013 Trinity College of Arts & Sciences
Faculty Network Member of the Duke Institute for Brain Sciences in the Institutes and Provost's Academic Units
2008 Institutes and Provost's Academic Units
Affiliate of the Duke Initiative for Science & Society in the Institutes and Provost's Academic Units
2014 Institutes and Provost's Academic Units
Member of the Duke Cancer Institute in the School of Medicine
1989 School of Medicine
Education
Ph.D. 1984
1984 University of Wisconsin - Madison
Publications, Grants & Awards
- Grants (47)
- Academics Articles (460)
- Book Sections (16)
- Conference Pages (44)
National Institutes of Health
National Institutes of Health
Philip Morris Products S.A.
Autism Research Institute
University of Maryland, Baltimore
National Institutes of Health
Environmental Protection Agency
National Institutes of Health
Philip Morris Products S.A.
Biomedical Research Institute of New Mexico
Woods Hole Oceanographic Institution
John Templeton Foundation
Autism Research Institute
National Institutes of Health
Rose Research Center, LLC
National Institutes of Health
Amygdala Neurosciences Inc.
National Institute of Environmental Health Sciences
National Institutes of Health
North Carolina State University
National Institutes of Health
John Templeton Foundation
National Institute of Environmental Health Sciences
National Institutes of Health
Georgetown University
Environmental Protection Agency
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Environmental Protection Agency
Environmental Protection Agency
National Institutes of Health
National Institutes of Health
National Institutes of Health
Environmental Protection Agency
National Institutes of Health
National Institutes of Health
National Institutes of Health
Environmental Protection Agency
National Science Foundation
National Institutes of Health
National Science Foundation
Pharmacol Biochem Behav
Aquat Toxicol
Neurotoxicology
Birth Defects Research
Neurotoxicol Teratol
Epigenetics & Chromatin
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Pharmacol Biochem Behav
Behav Brain Res
Neurotoxicol Teratol
Toxicological Sciences
Drug Alcohol Depend
Eur J Pharmacol
Nicotine Tob Res
Neurotoxicology
Pharmacol Biochem Behav
Environ Health Perspect
Psychopharmacology (Berl)
Neurotoxicol Teratol
Neurotoxicol Teratol
Neurotoxicol Teratol
Environmental Epigenetics
Front Toxicol
Scientific Reports
Neurotoxicology
Pharmacol Biochem Behav
Physiol Behav
Scientific Reports
Neurotoxicology and Teratology
Naunyn Schmiedebergs Arch Pharmacol
Scientific Reports
Neuropsychopharmacology
Psychopharmacology (Berl)
Pharmacol Biochem Behav
Neurotoxicology
Toxicological Sciences
Epigenetics : Official Journal of the Dna Methylation Society
Neurotoxicol Teratol
Neurotoxicol Teratol
Pharmacol Biochem Behav
Birth Defects Research
Toxicology
Pharmacol Biochem Behav
Toxicological Sciences
Eur J Pharmacol
Behav Brain Res
Toxicological Sciences
Journal of Drug and Alcohol Research
Pharmacol Biochem Behav
Neurotoxicol Teratol
Neurotoxicol Teratol
The Science of the Total Environment
Toxicological Sciences
Neurotoxicology
Neurotoxicology
Neurotoxicology and Teratology
Pharmacol Biochem Behav
Aquat Toxicol
Neurotoxicol Teratol
Epigenetics : Official Journal of the Dna Methylation Society
Neuropsychopharmacology
Psychopharmacology (Berl)
Neuropharmacology
Environ Toxicol Chem
Toxicological Sciences
Journal of Drug and Alcohol Research
Bmc Pharmacology & Toxicology
Psychopharmacology (Berl)
Toxicological Sciences
Environ Health Perspect
Invest New Drugs
Pharmacol Biochem Behav
Journal of Drug and Alcohol Research
Neurotoxicology
Neurotoxicol Teratol
Pharmacol Biochem Behav
Neuropharmacology
Pharmacol Biochem Behav
Pharmacol Biochem Behav
Eur J Pharmacol
Toxicological Sciences
Psychopharmacology (Berl)
Pharmacol Biochem Behav
Brain Res Bull
Journal of Drug and Alcohol Research
Neurotoxicol Teratol
Current Topics in Behavioral Neurosciences
Neurotoxicol Teratol
Neurotoxicol Teratol
Neurotoxicol Teratol
Neurotoxicol Teratol
Neurotoxicol Teratol
Neurotoxicol Teratol
Eur J Pharmacol
Prog Neuropsychopharmacol Biol Psychiatry
J Psychopharmacol
Pharmacol Biochem Behav
Pharmacol Biochem Behav
Biol Psychiatry
Neuropsychopharmacology
Neurotoxicol Teratol
Neurotoxicol Teratol
Journal of Medicinal Chemistry
Behav Brain Res
Eur J Pharmacol
Alcohol Clin Exp Res
Journal of Medicinal Chemistry
Psychopharmacology (Berl)
Birth Defects Res C Embryo Today
Eur J Pharmacol
Am J Physiol Endocrinol Metab
Environ Health Perspect
Journal of Pharmacology and Experimental Therapeutics
Psychopharmacology (Berl)
Recent Pat Cns Drug Discov
Psychopharmacology (Berl)
Pharmacol Biochem Behav
Eur J Pharmacol
Curr Drug Targets
Ann N Y Acad Sci
Neurology
Psychopharmacology (Berl)
Behav Processes
Neurotoxicol Teratol
Behav Brain Res
Biochemical Pharmacology
Biochemical Pharmacology
Journal of Pharmacology and Experimental Therapeutics
Pharmacol Biochem Behav
Psychopharmacology (Berl)
Psychopharmacology (Berl)
Psychopharmacology (Berl)
Pharmacol Biochem Behav
Eur J Pharmacol
Neurotoxicol Teratol
Neurotoxicol Teratol
Neurotoxicol Teratol
Neurotoxicol Teratol
Reviews in the Neurosciences
Neurotoxicol Teratol
Physiol Behav
Psychopharmacology (Berl)
Psychopharmacology (Berl)
Behav Brain Res
Journal of Pharmacology and Experimental Therapeutics
Alcohol and Alcoholism
Neurotoxicol Teratol
Pharmacol Biochem Behav
Biochem Pharmacol
Neurotoxicology
Psychopharmacology (Berl)
Alcohol Clin Exp Res
Environmental Health Perspectives
Brain Res Bull
Progress in Neuro Psychopharmacology & Biological Psychiatry
Progress in Neuro Psychopharmacology & Biological Psychiatry
Pharmacology, Biochemistry, and Behavior
Behav Brain Res
Behav Brain Res
Psychopharmacology (Berl)
Neurotoxicol Teratol
Neurotoxicology and Teratology
Brain Res Bull
Eur J Pharmacol
Environmental Health Perspectives
Physiology & Behavior
Environmental Health Perspectives
Pharmacology, Biochemistry, and Behavior
Toxicological Sciences
Progress in Neuro Psychopharmacology & Biological Psychiatry
Neurotoxicology
Brain Research Bulletin
Environmental Health Perspectives
The International Journal of Neuropsychopharmacology
Brain Research Bulletin
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Neurotoxicology
Biochemical Pharmacology
European Journal of Pharmacology
Pharmacology, Biochemistry, and Behavior
Pharmacology, Biochemistry, and Behavior
Psychopharmacology
Physiology & Behavior
Alcoholism, Clinical and Experimental Research
Neurotoxicology and Teratology
Pharmacology, Biochemistry, and Behavior
Psychopharmacology
Psychopharmacology
Environmental Health Perspectives
Neurobiology of Learning and Memory
Behavioural Brain Research
Environmental Health Perspectives
Physiology & Behavior
Psychopharmacology
Psychopharmacology
Progress in Neuro Psychopharmacology & Biological Psychiatry
Progress in Neuro Psychopharmacology & Biological Psychiatry
Neurotoxicology and Teratology
Pharmacology, Biochemistry, and Behavior
Neurotoxicology and Teratology
Neuropsychopharmacology
Alcoholism, Clinical and Experimental Research
Behavior Genetics
Birth Defects Research. Part A, Clinical and Molecular Teratology
Birth Defects Research. Part A, Clinical and Molecular Teratology
Neuropsychopharmacology
Progress in Neuro Psychopharmacology & Biological Psychiatry
Environmental Health Perspectives
Brain Research
Current Alzheimer Research
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Critical Reviews in Toxicology
Pharmacology, Biochemistry, and Behavior
European Journal of Pharmacology
European Journal of Pharmacology
Psychopharmacology
International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Toxicological Sciences
Brain Research Bulletin
Psychopharmacology
Pharmacology, Biochemistry, and Behavior
Pharmacology, Biochemistry, and Behavior
Brain Research. Cognitive Brain Research
European Journal of Pharmacology
Schizophrenia Research
Brain Research. Cognitive Brain Research
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Psychopharmacology
Journal of Neurobiology
Neuropsychopharmacology
Current Drug Targets. Cns and Neurological Disorders
Pharmacology, Biochemistry, and Behavior
The Journal of Ect
Psychopharmacology
Behavior Genetics
Drug Development Research
Drug Development Research
Neurotoxicology and Teratology
Pharmacology, Biochemistry, and Behavior
Environmental Health Perspectives
Brain Research. Developmental Brain Research
Biological Psychiatry
Experimental and Clinical Psychopharmacology
Neurotoxicology and Teratology
Physiology & Behavior
Toxicological Sciences
Neuropharmacology
Alcoholism, Clinical and Experimental Research
Behavioural Brain Research
Pharmacology, Biochemistry, and Behavior
European Journal of Pharmacology
Behavior Genetics
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Reviews in Toxicology
Behavioural Pharmacology
Drug Development Research
Drug Development Research
Pediatric Research
Psychopharmacology
Science (New York, N.Y.)
Brain Research. Cognitive Brain Research
Neurotoxicology and Teratology
Psychopharmacology
Pharmacology, Biochemistry, and Behavior
Behavior Genetics
Psychopharmacology
Environmental Health Perspectives
Journal of Cerebral Blood Flow and Metabolism
Alcoholism, Clinical and Experimental Research
Neuroscience
Pharmacology, Biochemistry, and Behavior
Environmental Health Perspectives
Drugs & Aging
Experimental Neurology
Physiology & Behavior
Behavioural Pharmacology
Brain Research Bulletin
Brain Research. Developmental Brain Research
Drug Development Research
Drug Development Research
Medicinal Chemistry Research
Drug Development Research
Neuropsychopharmacology
Neuropsychopharmacology
Psychopharmacology
Neuroscience
Psychopharmacology
Psychopharmacology
Neurotoxicology and Teratology
Psychopharmacology Bulletin
Pharmacology, Biochemistry, and Behavior
Journal of Traumatic Stress
Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences
Psychopharmacology
Biological Psychiatry
Pediatric Research
Journal of Clinical Psychopharmacology
Journal of Toxicology and Environmental Health
Journal of Clinical Psychopharmacology
Neurobiology of Learning and Memory
North Carolina Medical Journal
Brain Research Bulletin
Pharmacology, Biochemistry, and Behavior
Neuropsychopharmacology
Brain Research
Clinical Pharmacology and Therapeutics
Journal of Clinical Psychopharmacology
Drug Development Research
Drug Development Research
Experimental and Clinical Psychopharmacology
Drug Development Research
Schizophrenia Research
Therapeutic Drug Monitoring
Drug and Alcohol Dependence
Brain Research. Cognitive Brain Research
Archives of Internal Medicine
Pharmacology, Biochemistry, and Behavior
Clinical Research
Clinical Research
Pharmacology, Biochemistry, and Behavior
Drug and Alcohol Dependence
Pharmacology, Biochemistry, and Behavior
Neurotoxicology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Clinical Research
Brain Research. Developmental Brain Research
Neuroscience Letters
Behavioral and Neural Biology
Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association
Neurotoxicology and Teratology
Pharmacology, Biochemistry, and Behavior
Neurotoxicology and Teratology
Psychopharmacology
Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association
Brain Research Bulletin
Pharmacology, Biochemistry, and Behavior
British Journal of Addiction
Pharmacology, Biochemistry, and Behavior
Environmental Toxicology and Chemistry
Neurotoxicology and Teratology
Behavioral and Neural Biology
Drug and Alcohol Dependence
Physiology & Behavior
Drug and Alcohol Dependence
Clinical Pharmacology and Therapeutics
Behavioral and Neural Biology
Behavioural Brain Research
Behavioral and Neural Biology
Journal of Substance Abuse
Psychopharmacology
Behav Pharmacol
Brain Research
Pharmacology, Biochemistry, and Behavior
Pharmacology, Biochemistry, and Behavior
Behavioral and Neural Biology
Pharmacology, Biochemistry, and Behavior
Behavior Research Methods, Instruments, & Computers
Pharmacology, Biochemistry, and Behavior
Behavioral and Neural Biology
Bulletin of the Psychonomic Society
Movement Disorders : Official Journal of the Movement Disorder Society
Psychopharmacology
Neurotoxicology and Teratology
Psychopharmacology
L'Encephale
Behavioral and Neural Biology
Developmental Psychobiology
Behavioral and Neural Biology
Psychopharmacology
Archives of Toxicology
Neuroscience and Biobehavioral Reviews
Neurotoxicology and Teratology
Physiology & Behavior
Psychopharmacology
Experimental Neurology
Behavioral and Neural Biology
Brain Research
European Journal of Pharmacology
Pharmacology, Biochemistry, and Behavior
Psychopharmacology
Proceedings of the Western Pharmacology Society
Physiology & Behavior
Psychopharmacology
Pharmacology, Biochemistry, and Behavior
Anesthesia and Analgesia
Pharmacology, Biochemistry, and Behavior
American Journal of Primatology
Proceedings of the Western Pharmacology Society
Proceedings of the Western Pharmacology Society
Neurobehavioral Toxicology and Teratology
Neurobehavioral Toxicology and Teratology
Experimental Neurology
Experimental Neurology
Neurobehavioral Toxicology and Teratology
Neurobehavioral Toxicology and Teratology
Advances in Neurotoxicology
Neuromethods
Neuroscience of Nicotine: Mechanisms and Treatment
Handbook of Developmental Neurotoxicology
Handbook of Developmental Neurotoxicology
Advances in Neurotoxicology
ZEBRAFISH MODELS IN NEUROBEHAVIORAL RESEARCH
Hayes' Handbook of Pesticide Toxicology, Third Edition: Volume 1
METHODS OF BEHAVIOR ANALYSIS IN NEUROSCIENCE, SECOND EDITION
Animal Models of Cognitive Impairment
Animal Models of Cognitive Impairment
Animal Models of Cognitive Impairment
Nicotinic Receptors in the Nervous System
Nicotinic Receptors in the Nervous System
Nicotinic Receptors in the Nervous System
Methods of Behavior Analysis in Neuroscience
Birth Defects Research
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Neuropsychopharmacology
Environmental and Molecular Mutagenesis
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Environmental and Molecular Mutagenesis
Biochemical Pharmacology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Eur J Pharmacol
Alcoholism, Clinical and Experimental Research
Neurotoxicology and Teratology
Neurotoxicology and Teratology
Biochemical Pharmacology
Alcoholism, Clinical and Experimental Research
Neurotoxicology and Teratology
Abstracts of Papers of the American Chemical Society
Neurotoxicology and Teratology
Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
Neurotoxicology and Teratology
Alcoholism, Clinical and Experimental Research
Journal of the American Geriatrics Society
Alcoholism, Clinical and Experimental Research
American Journal of Geriatric Psychiatry
Biochemical Pharmacology
Neurotoxicology and Teratology
Neurotoxicology
Neurotoxicology
Neurotoxicology and Teratology
Neurotoxicology and Teratology
The International Journal of Neuropsychopharmacology
The International Journal of Neuropsychopharmacology
Neuropsychopharmacology
Alcoholism, Clinical and Experimental Research
Biological Psychiatry
Toxicological Sciences
Toxicological Sciences
EFFECTS OF NICOTINE ON BIOLOGICAL SYSTEMS II
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