Jack Keene
James B. Duke Distinguished Professor of Molecular Genetics and Microbiology
Overview
The Keene Laboratory has a long-term interest in the structure and function of viral and mammalian genomes. Having determined the first genomic sequences for rabies, Ebola, Marburg and vesicular stomatitis virus, and discerned the origins of defective interfering viruses, interests shifted to the cloning of six human genes involved in autoimmune reactivity. This resulted in the identification of numerous autoimmune RRM-type RNA-binding proteins the discovery of the RRM, and the RNA targets to which they bind. The current interests of the lab surround the functions of the human RRM-ELAV/Hu proteins that are bound to a subset of cellular mRNAs involved in growth regulation neuronal plasticiyt and cancer. The laboratory demonstrated that ELAV/Hu proteins bind and regulate the expression of early response gene transcripts such as those encoding the protooncogene and cytokine proteins.
In addition, it was shown that while stabilizing these mRNAs and/or activating their translation, the ELAV/Hu proteins participate in cellular , differentiation and carcinogenesis. More recently, the laboratory has examined dozens of RNA-binding proteins in order to identify large numbers of structurally
and/or functionally related mRNAs that cluster in vivo based upon their binding to these proteins. This has been termed ribonomics because it involves parallel analysis of mRNA subsets en masse based upon their presence in messenger ribonucleoprotein complexes. This new approach to functional genomics is being applied to virus-infected cells, tumors and cells treated with various agents. Ribonomics has led to the identification of mRNA clusters that are posttranscriptionally regulated, and represent the organizational state of genetic information between the genome and the proteome. Dr. Keen has propsed the existence of post-transcriptional operons based upon the association of structurally and functionally-linked mRNAs in vivo.
Positions
James B. Duke Distinguished Professor of Molecular Genetics and Microbiology in the School of Medicine
1997 School of Medicine
Professor of Molecular Genetics and Microbiology in the School of Medicine
1989 School of Medicine
Associate Professor in Medicine in the School of Medicine
2020 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1979 School of Medicine
Education
Ph.D. 1974
1974 University of Washington
Publications, Grants & Awards
- Grants (32)
- Awards (5)
- Academics Articles (179)
- Conference Pages (10)
- Book Sections (2)
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Cancer Institute
National Institutes of Health
National Institutes of Health
National Science Foundation
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
The LARP (La-And-Related-Protein) Society
The American Association for the Advancement of Science
The Henry Kunkel Honorary Society
American Society of Microbiology
The Pew Charitable Trusts
Curr Opin Genet Dev
Cell Physiol Biochem
Proc Natl Acad Sci U S A
Nucleic Acids Res
Scientific Reports
Semin Cell Dev Biol
National Science Review
Genome Biology
Curr Opin Genet Dev
Nucleic Acids Res
Current Topics in Behavioral Neurosciences
Wiley Interdiscip Rev Syst Biol Med
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology
Molecular Systems Biology
J Neurochem
Molecular and Cellular Biology
The Journal of Cell Biology
Rna Biol
Methods in Molecular Biology (Clifton, N.J.)
Plos Pathog
Nature Reviews. Genetics
Plos Pathogens
Cold Spring Harbor Symposia on Quantitative Biology
Molecular Biology of the Cell
Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
Molecular Cancer
Microbiology and Molecular Biology Reviews : Mmbr
Nature Structural & Molecular Biology
Supplements to Clinical neurophysiology
Methods in Molecular Biology (Clifton, N.J.)
Molecular Cell
Molecular Cell
Rna (New York, N.Y.)
Proceedings of the National Academy of Sciences of the United States of America
Nature Genetics
Molecular Cell
Rna (New York, N.Y.)
Molecular Biology of the Cell
Methods (San Diego, Calif.)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
The Journal of Biological Chemistry
The Journal of Biological Chemistry
American Journal of Human Genetics
Genes & Development
Genes & Development
Proceedings of the National Academy of Sciences of the United States of America
Methods in Molecular Biology (Clifton, N.J.)
Methods in Molecular Biology (Clifton, N.J.)
Journal of Cell Science
Current Biology : Cb
Journal of Cell Science
American Journal of Human Genetics
Molecular and Cellular Biology
Scientist
Chemistry & Biology
Journal of Cell Science
Rna (New York, N.Y.)
Molecular Biology Reports
Methods in Enzymology
Genes & Development
Journal of Virology
Nucleic Acids Symposium Series
Proceedings of the National Academy of Sciences of the United States of America
Journal of Virology
Molecular and Cellular Biology
The Journal of Immunology
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
The Journal of Clinical Investigation
Molecular and Cellular Biology
Trends in Biochemical Sciences
Journal of Virology
Molecular and Cellular Biology
The Journal of Immunology
Proceedings of the National Academy of Sciences of the United States of America
Nucleic Acids Research
Rheumatic Disease Clinics of North America
Nucleic Acids Research
Trends in Biochemical Sciences
Molecular and Cellular Biology
The Journal of Immunology
Proceedings of the National Academy of Sciences of the United States of America
Molecular and Cellular Biology
Nucleic Acids Research
Progress in Nucleic Acid Research and Molecular Biology
Nucleic Acids Research
Proceedings of the National Academy of Sciences of the United States of America
The Journal of Immunology
Clinical Immunology and Immunopathology
The Journal of Clinical Investigation
Arthritis and Rheumatism
Molecular Biology Reports
Molecular Biology Reports
Molecular and Cellular Biology
Journal of Virology
Journal of Autoimmunity
Journal of Autoimmunity
Molecular and Cellular Biology
The Journal of Immunology
The Journal of Biological Chemistry
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Arthritis and Rheumatism
Molecular Biology Reports
Molecular Biology Reports
Molecular Biology Reports
Molecular Biology Reports
Molecular Biology Reports
Molecular and Cellular Biology
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Immunology
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Virology
Microbiological Sciences
Proceedings of the National Academy of Sciences of the United States of America
Journal of Virology
Journal of Virology
The Journal of Biological Chemistry
Proceedings of the National Academy of Sciences of the United States of America
Virology
The Journal of Biological Chemistry
Proceedings of the National Academy of Sciences of the United States of America
Journal of Virology
The Journal of General Virology
Proceedings of the National Academy of Sciences of the United States of America
The Journal of General Virology
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Journal of Virology
Journal of Virology
Journal of Virology
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Hepatology (Baltimore, Md.)
Cancer Research
Cold Spring Harbor Symposia on Quantitative Biology
Arthritis and Rheumatism
Clinical Research
Clinical Research
Clinical Research
TEN YEARS OF PROGRESS IN GW/P BODY RESEARCH
Technical, Conceptual, and Administrative Lessons of the Income Survey Development Program (IDSP)
Offices & Contact
Durham, NC
27717 Duke Box 3020
Durham, NC
27710