Jed Rose
Professor Emeritus in Psychiatry and Behavioral SciencesOverview
We are pursuing three main lines of research:
1) Brain imaging of the effects of nicotine and cigarette smoking: We have used Positron Emission Tomography (PET) methods to analyze regional cerebral blood flow responses to nicotine, administered either intravenously or inhaled in cigarettes. Our aim is to identify brain substrates mediating the addictive properties of nicotine. Preliminary results have shown alterations in the pattern of regional cerebral blood flow, involving frontal cortex, amygdala and other brain regions. We will continue to delineate the similarities and differences between the effects of nicotine and other drugs on regional brain activity, and plan to monitor the changes in response to nicotine after smoking cessation with nicotine antagonist treatment.
2) Analysis of airway sensory components of smoking reinforcement: We have continued the study the role of sensorimotor aspects of cigarette smoking in relieving craving for cigarettes and regulating smoke intake. We completed a study of the effects of intravenous nicotine presented alone or in combination with the sensorimotor aspects of smoking using de-nicotinized cigarette smoke. Craving for cigarettes was relieved more effectively by the de-nicotinized smoke than by the intravenous nicotine. Current studies underway at the Clinical Research Unit will further investigate the subjective effects of i.v. nicotine and de-nicotinized cigarette smoke, using a wider range of nicotine doses. Possible predictors of clinical outcome following nicotine skin patch treatment will be identified based on acute responses to the pharmacologic effects of nicotine in the laboratory.
We are also continuing to further the clinical application of these findings by developing substitutes that provide the airways sensory effects of smoking (e.g. citric acid aerosol).
3) Agonist/antagonist combination treatment for drug dependence: In a double blind smoking cessation trial using mecamylamine, a nicotinic antagonist, in combination with nicotine skin patches, we found that addition of the antagonist substantially increases smoking abstinence throughout the 1 year follow-up. Two additional studies that we conducted support the view that pre-treatment with mecamylamine prior to smoking cessation may be a critical factor in achieving high success rates. By blocking reinforcing effects of nicotine, smoking behavior may be partially extinguished, thereby facilitating subsequent smoking cessation. We recently completed a Phase II FDA trial evaluating a transdermal patch delivering nicotine and mecamylamine, which replicated our previous results. It is anticipated that an NDA pertaining to the new skin patch will be submitted in 1997. Continuing studies in our program will determine the optimal dose and duration of treatment. We also have initiated studies to extend this approach to the treatment of other drug dependencies, including cocaine.
Positions
Professor Emeritus in Psychiatry and Behavioral Sciences in the School of Medicine
2022 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1989 School of Medicine
Education
Ph.D. 1978
1978 University of California - San Diego
Publications, Grants & Awards
- Grants (35)
- Academics Articles (220)
- Conference Pages (2)
- Book Sections (2)
National Institutes of Health
National Institutes of Health
National Institutes of Health
Altria Client Services LLC
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Drug Alcohol Depend
Jama Network Open
Psychopharmacology (Berl)
Nicotine Tob Res
Aerosol Science and Technology
Intern Emerg Med
Psychopharmacology (Berl)
Drug Alcohol Depend
Behav Brain Res
Drug Alcohol Depend
Jmir Research Protocols
Measurement: Journal of the International Measurement Confederation
Psychopharmacology (Berl)
Drugs and Alcohol Today
Nicotine Tob Res
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Psychopharmacology (Berl)
Pharmacol Biochem Behav
Journal of Smoking Cessation
Addiction
Nicotine Tob Res
Nicotine Tob Res
J Neurosci Methods
Psychopharmacology (Berl)
Addict Biol
Pharmacol Biochem Behav
Pharmacol Biochem Behav
Eur J Pharmacol
Neuropsychopharmacology
American Journal of Psychiatry
Neuropsychopharmacology
Pharmacol Biochem Behav
Nicotine Tob Res
J Neurosci Res
American Journal of Psychiatry
Neuropsychopharmacology
Prog Neuropsychopharmacol Biol Psychiatry
Jama Psychiatry
The American Journal of Psychiatry
Pharmacol Biochem Behav
Molecular Psychiatry
Behav Brain Res
Translational Psychiatry
American Journal of Psychiatry
Clinical Pharmacology and Therapeutics
Nicotine Tob Res
Biol Psychiatry
Psychopharmacology (Berl)
Journal of Pharmacology and Experimental Therapeutics
Addict Sci Clin Pract
Pharmacol Biochem Behav
Eur J Pharmacol
Physiol Behav
Exp Clin Psychopharmacol
Molecular Medicine
Biol Psychiatry
Exp Clin Psychopharmacol
Psychopharmacology (Berl)
Psychopharmacology (Berl)
Psychopharmacology (Berl)
Proc Natl Acad Sci U S A
Journal of Pharmacology and Experimental Therapeutics
Nicotine Tob Res
J Neurosci Res
Psychopharmacology (Berl)
The International Journal of Neuropsychopharmacology
Pharmacogenomics J
Behav Brain Res
Nebraska Symposium on Motivation. Nebraska Symposium on Motivation
Eur J Pharmacol
Ann N Y Acad Sci
Neuropsychopharmacology
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Arch Gen Psychiatry
Psychopharmacology
Neuropsychopharmacology
Psychopharmacology
Biochemical Pharmacology
Addictive Behaviors
Bmc Genetics
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Psychopharmacology
Addiction (Abingdon, England)
Psychopharmacology
Psychopharmacology
Psychopharmacology
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Ieee Nuclear Science Symposium Conference Record
Neuropsychopharmacology
Experimental and Clinical Psychopharmacology
Addictive Behaviors
Addictive Behaviors
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Addictive Behaviors
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Psychopharmacology
Pharmacology, Biochemistry, and Behavior
Pharmacology, Biochemistry, and Behavior
Schizophrenia Research
The American Journal of Psychiatry
Alcoholism, Clinical and Experimental Research
Alcoholism, Clinical and Experimental Research
Psychopharmacology
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Pharmacology, Biochemistry, and Behavior
Physiology & Behavior
Pharmacology, Biochemistry, and Behavior
American Journal of Health Behavior
Drug and Alcohol Dependence
Psychopharmacology
Pharmacology, Biochemistry, and Behavior
Psychopharmacology
Experimental and Clinical Psychopharmacology
Food and Drug Law Journal
Addiction (Abingdon, England)
Psychopharmacology
Archives of Internal Medicine
Drug Development Research
Drug Development Research
Neuropsychopharmacology
Physiology & Behavior
Pharmacology, Biochemistry, and Behavior
Drug Development Research
Psychopharmacology
Psychopharmacology Bulletin
Annual Review of Medicine
Journal of Traumatic Stress
Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences
Psychopharmacology
Biological Psychiatry
Experimental and Clinical Psychopharmacology
Experimental and Clinical Psychopharmacology
North Carolina Medical Journal
Pharmacology, Biochemistry, and Behavior
Clinical Pharmacology and Therapeutics
Journal of Clinical Psychopharmacology
Drug and Alcohol Dependence
Experimental and Clinical Psychopharmacology
Experimental and Clinical Psychopharmacology
Drug Development Research
Therapeutic Drug Monitoring
Drug and Alcohol Dependence
Brain Research. Cognitive Brain Research
Archives of Internal Medicine
Pharmacology, Biochemistry, and Behavior
Drug Development and Industrial Pharmacy
Drug and Alcohol Dependence
Pharmacology, Biochemistry, and Behavior
Neurotoxicology and Teratology
Behavioral and Neural Biology
Journal of Psychopharmacology (Oxford, England)
Pharmacology, Biochemistry, and Behavior
Pharmacology, Biochemistry, and Behavior
Pharmacology, Biochemistry, and Behavior
Brain Research Bulletin
Pharmacology, Biochemistry, and Behavior
British Journal of Addiction
Pharmacology, Biochemistry, and Behavior
Pharmacology, Biochemistry, and Behavior
Behavioral and Neural Biology
Drug and Alcohol Dependence
Drug and Alcohol Dependence
Clinical Pharmacology and Therapeutics
Behavioral and Neural Biology
Behavioral and Neural Biology
Journal of Substance Abuse
Behavior Research Methods, Instruments, & Computers
Pharmacology, Biochemistry, and Behavior
Behavior Research Methods, Instruments, & Computers
Pharmacology, Biochemistry, and Behavior
Annals of Behavioral Medicine
Addictive Behaviors
Nida Research Monograph Series
Alimentary Pharmacology & Therapeutics
The New England Journal of Medicine
Progress in Clinical and Biological Research
Journal of Substance Abuse
Journal of Psychoactive Drugs
Pharmacology, Biochemistry, and Behavior
Behavior Research Methods, Instruments, & Computers
Alcohol and Drug Research
Pharmacology, Biochemistry, and Behavior
Clinical Pharmacology and Therapeutics
Pharmacology, Biochemistry, and Behavior
Addictive Behaviors
Drug and Alcohol Dependence
Pharmacology, Biochemistry, and Behavior
Addictive Behaviors
Addictive Behaviors
Pharmacology, Biochemistry, and Behavior
Addictive Behaviors
Acta Geneticae Medicae Et Gemellologiae
Nida Research Monograph Series
Behavior Research Methods
Learning and Motivation
Neuropsychopharmacology
Journal of Physics: Conference Series
Medication Treatments for Nicotine Dependence
Nicotinic Receptors in the Nervous System
Offices & Contact
Durham, NC
27705 Box 2701 Med Ctr
Durham, NC
27710