John Sampson
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine
Overview
Current research activities involve the immunotherapeutic targeting of a tumor-specific mutation in the epidermal growth factor receptor. Approaches used to target this tumor-specific epitope include unarmed and radiolabeled antibody therapy and cell mediated approaches using peptide vaccines and dendritic cells. Another area of interest involves drug delivery to brain tumors. Translational and clinical work is carried out in this area to formulate the relationship between various direct intratumoral infusion parameters and drug distribution within brain tumors and normal brain.
The Duke Brain Tumor Immunotherapy Program (BTIP) has an emphasis on translational research in Neuro-Oncology. There are two main areas of study. The first is novel mechanisms of delivery of large molecular weight molecules, such as monoclonal antibodies, throughout brain intersitial space using novel intracerebral infusion techniques developed by this laboratory. Studies exploring this technology are undertaken in both small and large laboratory animals and patients with brain tumors.
The other focus of the BTIP is translational immunotherapy. In this line of work, dendritic cell vaccination strategies and adoptive T-cell strategies have been developed to target novel and well-characterized tumor-specific antigens in patients with brain tumors. The BTIP integrates well with and works closely with the Preston Robert Tisch Brain Tumor Center at Duke. The BTIP is well funded and currently holds seven NIH grants, including a SPORE in Brain Cancer grant. There are a large number of investigators at various levels so that students will get exposure to various levels of research and mentorship.
Positions
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine in the School of Medicine
2009 School of Medicine
Professor of Neurosurgery in the School of Medicine
2009 School of Medicine
Professor of Biomedical Engineering in the Pratt School of Engineering
2013 Pratt School of Engineering
Professor of Integrative Immunobiology in the School of Medicine
2009 School of Medicine
Professor of Radiation Oncology in the School of Medicine
2009 School of Medicine
Professor of Pathology in the School of Medicine
2012 School of Medicine
Professor in Orthopaedic Surgery in the School of Medicine
2017 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1990 School of Medicine
Education
M.D. 1990
1990 University of Manitoba (Canada)
Ph.D. 1996
1996 Duke University
M.H.S. 2007
2007 Duke University School of Medicine
M.B.A. 2011
2011 Duke University
Investigator in Cerebral Hydrodynamics Lab, Neurosurgery
1989 University of Manitoba (Canada)
Intern, Surgery
1991 Duke University
Resident in Neurosurgery, Surgery
1998 Duke University
Publications, Grants & Awards
- Grants (58)
- Awards (1)
- Academics Articles (360)
- Book Sections (14)
- Conference Pages (71)
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
University of North Carolina - Chapel Hill
National Pediatric Cancer Foundation, Inc.
National Institutes of Health
National Institutes of Health
North Carolina Biotechnology Center
Department of Defense
National Institutes of Health
University of North Carolina - Chapel Hill
Department of Defense
National Institutes of Health
National Institutes of Health
National Institutes of Health
Pediatric Brain Tumor Foundation
National Institutes of Health
University of Florida
University of Florida
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
University of California - San Francisco
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Yuhan Corporation
St. Jude Children's Research Hospital
National Institutes of Health
BrainLAB, Inc.
National Cancer Institute
National Institutes of Health
The Cure Starts Now
American Brain Tumor Association
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Academy of Medicine
World Neurosurg
Nature Cancer
Advances in Radiation Oncology
Frontiers in Immunology
Anesth Analg
Nature Communications
Science Advances
Neurocritical Care
Clinical Cancer Research
Clinical Cancer Research
Neurocritical Care
Methods Mol Biol
Neuro Oncology Advances
J Immunol Methods
Journal for Immunotherapy of Cancer
Neurocritical Care
Clinical Cancer Research
Nature Communications
Frontiers in Oncology
Advances in Radiation Oncology
Clinical Cancer Research
Clinical Cancer Research
European Journal of Cancer
Expert Rev Clin Pharmacol
Pharmaceutics
Nature Communications
Expert Opin Biol Ther
Clinical Cancer Research
Journal for Immunotherapy of Cancer
J Clin Invest
Nat Rev Cancer
Clinical Cancer Research
Nature Reviews. Clinical Oncology
Nature Reviews. Clinical Oncology
Clinical Cancer Research
Cancer Res
Clinical Cancer Research
Health Science Reports
Clinical Cancer Research
Neurosurgery
J Clin Neurosci
Clinical Cancer Research
J Immunol Methods
The New England Journal of Medicine
Neurosurgical Focus
Oncoimmunology
Acs Biomaterials Science & Engineering
J Neurosurg
Lancet Oncol
Expert Rev Clin Immunol
Chinese Neurosurgical Journal
World Neurosurg
Journal of Clinical Oncology
Neurosurgery
Curr Opin Neurol
Clinical Cancer Research
Expert Opin Biol Ther
J Neurooncol
Expert Opin Drug Saf
Expert Rev Vaccines
Advances in Radiation Oncology
Frontiers in Immunology
Clinical Cancer Research
Expert Opin Emerg Drugs
J Alzheimers Dis
Clinical Cancer Research
Cancer Immunol Immunother
Neuro Oncol
Lancet Oncol
J Neurosurg
J Neurosurg
Neuro Oncol
J Neurooncol
Neuro Oncol
Oncoimmunology
Cancer Immunol Res
Cancer Immunol Immunother
Oncoimmunology
Oncoimmunology
Journal of Visualized Experiments : Jove
Int J Radiat Oncol Biol Phys
Expert Opin Biol Ther
Surgical Neurology International
J Clin Invest
Clinical Cancer Research
Neuro Oncol
Expert Opin Pharmacother
Semin Radiat Oncol
Clinical Cancer Research
J Neurosurg
J Neurosurg
Clinical Cancer Research
J Neurosurg
J Clin Neurosci
Immunotherapy
Oncoimmunology
Journal of Radiosurgery and Sbrt
Oncoimmunology
Oncoimmunology
Cancer Immunol Immunother
Molecular Therapy : the Journal of the American Society of Gene Therapy
J Clin Neurosci
J Immunol Methods
Pediatric Blood & Cancer
Cancer Immunol Res
Int J Radiat Oncol Biol Phys
Neurosurgery
Surg Oncol Clin N Am
Expert Rev Clin Pharmacol
The Journal of Clinical Investigation
Cancer Immunol Immunother
Expert Rev Vaccines
Cancer Treat Rev
Oncoimmunology
Drugs of the Future
J Bone Joint Surg Am
Proceedings of the National Academy of Sciences of the United States of America
J Neurosurg
Current Drug Discovery Technologies
J Neurosurg
Curr Drug Discov Technol
Clinical Cancer Research
Nature Chemical Biology
Lancet Oncol
British Journal of Cancer
J Natl Compr Canc Netw
J Neurosurg
Technology in Cancer Research & Treatment
Int J Radiat Oncol Biol Phys
Neurosurg Clin N Am
J Neurooncol
J Neurosurg
J Neurosurg
J Neurosurg
Int J Radiat Oncol Biol Phys
J Neurooncol
Clin Dev Immunol
Journal of Surgical Radiology
Journal of Clinical Oncology
Crit Rev Oncol Hematol
J Neurosurg
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
J Neurosurg
Clinical Cancer Research
Expert Opin Biol Ther
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
J Neurosurg
J Natl Compr Canc Netw
Future Oncol
J Neurosurg
Neuro Oncol
Journal of Neuro Oncology
Journal of Clinical Oncology
Neuro Oncol
Curr Neurol Neurosci Rep
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Neuro Oncology
J Neurooncol
Neuromethods
Neurosurg Clin N Am
Neurosurg Clin N Am
British Journal of Cancer
Mol Cancer Ther
Neuro Oncology
Int J Cancer
Expert Opin Biol Ther
Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
American Journal of Clinical Oncology
Journal of Neurochemistry
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology
Int J Radiat Oncol Biol Phys
Neuro Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Neurosurgery
Journal of Immunological Methods
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Neurosurgery
Seminars in Immunology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Neuro Oncology
Neuro Oncology
Future Oncol
Expert Rev Anticancer Ther
Neurosurgical Review
Immunol Rev
Neuro Oncology
Journal of Neurosurgery
Cancer Immunology, Immunotherapy
Journal of Clinical Oncology
Neuro Oncology
Journal of Neuro Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Expert Rev Neurother
Journal of Clinical Oncology
Gynecologic Oncology
Ajr. American Journal of Roentgenology
Journal of Neuroimmunology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Neurologia Medico Chirurgica
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Neurosurgical Focus
Neurosurgical Focus
Neurosurgical Focus
Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Neuro Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Neurosurgery
Neuro Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Ethnopharmacology
Current Problems in Surgery
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Journal (Sudbury, Mass.)
Journal of Neuro Oncology
Neuroimaging Clinics of North America
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Neuroimaging Clinics of North America
Ajnr. American Journal of Neuroradiology
Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Immunology, Immunotherapy
Neuro Oncology
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Expert Opinion on Therapeutic Targets
Proceedings of the National Academy of Sciences of the United States of America
Journal of Neuroimmunology
Phytotherapy Research : Ptr
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Neuro Oncology
Cancer Metastasis Reviews
Journal of Neuro Oncology
Journal of Neuroimmunology
Journal of Neurosurgery
Neurosurgery
Journal of Neuroimmunology
Journal of Neurovirology
Aids Research and Human Retroviruses
American Journal of Respiratory and Critical Care Medicine
Proceedings of the National Academy of Sciences of the United States of America
Journal of Neurosurgery
Neurosurgery
Journal of Neurosurgery
Lancet (London, England)
Annals of Internal Medicine
Surgical Neurology
The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Journal of Neurosurgery
American Family Physician
Handbook for Designing and Conducting Clinical and Translational Surgery
Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy: Second Edition
Complications in Neurosurgery
Translational Immunotherapy of Brain Tumors
Translational Immunotherapy of Brain Tumors
Translational Immunotherapy of Brain Tumors
The Duke Glioma Handbook: Pathology, Diagnosis, and Management
The Duke Glioma Handbook: Pathology, Diagnosis, and Management
The Duke Glioma Handbook
Malignant Brain Tumors: State-of-the-Art Treatment
NEURO-ONCOLOGY: THE ESSENTIALS, 3RD EDITION
Tumors of the Central Nervous System, Volume 1
Modern Neurosurgery: Clinical Translation of Neuroscience Advances
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Neuro Oncology
The Journal of Immunology
The Journal of Immunology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Immunology Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
The Journal of Immunology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
The Journal of Immunology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Annals of Oncology
Neuro Oncology
Molecular Cancer Therapeutics
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Neurology
Neuro Oncology
Neuro Oncology
Neuro Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Neurosurgery
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Neuro Oncology
Neuro Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Neuro Oncology
Neuro Oncology
Neuro Oncology
Neuro Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Neuro Oncology
Offices & Contact
Durham, NC
27710 Box 3810 Med Ctr
Durham, NC
27710