Keith Sullivan
James B. Wyngaarden Distinguished Professor Emeritus of Medicine
Overview
Research areas
- Late effects of cancer treatment and stem cell transplantation
- Chronic graft-versus-host disease
- Transplantation for sickle cell and autoimmune diseases
- Knowledge engineering
Overview
Early on, Dr. Sullivan and the team at Fred Hutchinson Cancer Research Center developed a systematic investigative approach for the diagnosis and treatment of chronic graft-versus-host disease (GVHD), the major cause of late morbidity and non-relapse mortality following allogeneic stem cell transplantation (SCT). As a result of this work, it became clear that blood and marrow transplant recipients require systematic long-term follow-up to evaluate and treat late complications of high-dose chemoradiotherapy and SCT.
The program grew into a large multidisciplinary team, resulting in improvement in patient outcome and quality of life. Through the late events project, he also contributed to outcomes research, computer decision support systems, and knowledge engineering for follow-up care. With quality of life as a focus, research pursued the application of SCT to diseases with high morbidity but little immediate mortality. For young patients with advanced, symptomatic sickle cell disease, myeloablative conditioning and SCT from an HLA-identical sibling has led to an 86% long-term survival free of sickle cell disease. For individuals with autoimmune diseases such as multiple sclerosis, scleroderma, and systemic lupus erythematosus, current therapy is often incomplete and significant morbidity from the disease or its treatment is observed.
Recent preclinical and clinical data suggest that high-dose immunosupression and SCT can halt the progression and, in some settings, reverse the course of autoimmune diseases. Since his arrival at Duke University, over 30 centers nationwide are participating in Duke-led phase II and III trials to test the toxicity, efficacy, and quality of life following autologous and allogeneic stem cell transplantation for autoimmune diseases.
These trials will also serve as platforms to study the immune repertoire and mechanistic pathways before and after SCT to gain greater insight into the basic mechanisms of autoimmunity.
A national repository of tissue and cell specimens is also part of these NIH-supported trials to further promote scientific study from these unique patients.
Positions
James B. Wyngaarden Distinguished Professor Emeritus of Medicine in the School of Medicine
2023 School of Medicine
Professor Emeritus of Medicine in the School of Medicine
2023 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1999 School of Medicine
Education
M.D. 1971
1971 Indiana University at Indianapolis
Publications, Grants & Awards
- Grants (16)
- Awards (9)
- Academics Articles (446)
- Conference Pages (27)
- Book Sections (2)
National Institutes of Health
National Institutes of Health
National Institutes of Health
Jazz Pharmaceuticals
National Institutes of Health
University of Pittsburgh
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
American Society for Transplantation and Cellular Therapy
American Society for Transplantation and Cellular Therapy
Kelly Government Solutions
Society of Clinical Trials
DUke Department of Medicine
DUke Department of Medicine
American Association for the Advancement of Science
Institute for Scientific Information (ISI)
Association of American Physicians
Transplant Cell Ther
Transplant Cell Ther
Rheumatology (Oxford)
Arthritis Care & Research
Frontiers in Immunology
Rheumatology (Oxford)
Hum Vaccin Immunother
J Scleroderma Relat Disord
Arthritis Rheumatol
Bone Marrow Transplant
Current Oncology (Toronto, Ont.)
Biol Blood Marrow Transplant
Nat Rev Rheumatol
Current Oncology (Toronto, Ont.)
Lancet Respir Med
Biol Blood Marrow Transplant
Nat Rev Rheumatol
Curr Opin Hematol
Br J Dermatol
Ann Rheum Dis
Jama Dermatol
Biol Blood Marrow Transplant
Biol Blood Marrow Transplant
Biol Blood Marrow Transplant
Arch Pathol Lab Med
Biol Blood Marrow Transplant
Biol Blood Marrow Transplant
Jmir Mhealth and Uhealth
The New England Journal of Medicine
The New England Journal of Medicine
Bone Marrow Transplant
Biol Blood Marrow Transplant
Biol Blood Marrow Transplant
Biol Blood Marrow Transplant
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Arthritis Rheumatol
Journal of Hematology & Oncology
Biol Blood Marrow Transplant
Annals of Behavioral Medicine
J Clin Invest
Biol Blood Marrow Transplant
Curr Opin Rheumatol
Bone Marrow Transplantation
The Journal of Rheumatology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biol Blood Marrow Transplant
Bone Marrow Transplant
Bone Marrow Transplantation
Bone Marrow Transplantation
Lancet (London, England)
Bone Marrow Transplant
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biol Blood Marrow Transplant
Int J Radiat Oncol Biol Phys
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
The New England Journal of Medicine
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biol Blood Marrow Transplant
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Bone Marrow Transplant
Bone Marrow Transplant
Biol Blood Marrow Transplant
Bone Marrow Transplant
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Bone Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
British Journal of Haematology
Journal of Clinical Oncology
British Journal of Haematology
Clinical Immunology (Orlando, Fla.)
The New England Journal of Medicine
Arthritis and Rheumatism
Blood Reviews
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Clinical Immunology (Orlando, Fla.)
The Journal of Rheumatology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Information Sciences
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
The Journal of Pediatrics
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Bone Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Turkish Journal of Cancer
Rheumatology (Oxford, England)
International Journal of Hematology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Transplantation
Annals of the Rheumatic Diseases
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Hematology. American Society of Hematology. Education Program
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Proceedings of the Joint Conference on Information Sciences
Proceedings of the Joint Conference on Information Sciences
Proceedings of the Joint Conference on Information Sciences
Bone Marrow Transplantation
Journal of the American Dietetic Association
Hematology (Amsterdam, Netherlands)
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Hematology Am Soc Hematol Educ Program
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Evaluation & the Health Professions
Hematology/Oncology Clinics of North America
Hepatology (Baltimore, Md.)
Journal of the American Medical Informatics Association : Jamia
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Bone Marrow Transplantation
Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences
The American Journal of Medicine
The New England Journal of Medicine
Gastroenterology
Proceedings. Amia Symposium
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Journal of the American Medical Informatics Association : Jamia
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Journal of Hematotherapy
The Journal of Rheumatology. Supplement
The Journal of Rheumatology. Supplement
The Journal of Rheumatology. Supplement
The Journal of Rheumatology. Supplement
The Journal of Rheumatology. Supplement
Bone Marrow Transplantation
Current Eye Research
American Journal of Hematology
Jpen. Journal of Parenteral and Enteral Nutrition
The New England Journal of Medicine
The New England Journal of Medicine
Transplantation Proceedings
Clinical and Experimental Immunology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
British Journal of Haematology
British Journal of Haematology
Bone Marrow Transplantation
British Journal of Haematology
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Transplantation
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Therapeutics
Bone Marrow Transplantation
International Journal of Radiation Oncology, Biology, Physics
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Social Science & Medicine
Bone Marrow Transplantation
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Current Opinion in Hematology
Blood Reviews
Clinical and Experimental Immunology
The New England Journal of Medicine
American Journal of Hematology
The American Journal of Pediatric Hematology/Oncology
The American Journal of Pediatric Hematology/Oncology
The American Journal of Pediatric Hematology/Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bone Marrow Transplantation
British Journal of Haematology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bone Marrow Transplantation
Bone Marrow Transplantation
Oncology Nursing Forum
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Archives of Dermatology
Transplantation
Bone Marrow Transplantation
The Journal of Infectious Diseases
Annals of Internal Medicine
Bone Marrow Transplantation
Bone Marrow Transplantation
British Journal of Haematology
American Journal of Physiologic Imaging
Bone Marrow Transplantation
International Journal of Radiation Oncology, Biology, Physics
Bone Marrow Transplantation
Bone Marrow Transplantation
The New England Journal of Medicine
Seminars in Hematology
Seminars in Hematology
Seminars in Hematology
Seminars in Hematology
Bone Marrow Transplantation
Bone Marrow Transplantation
Bone Marrow Transplantation
The New England Journal of Medicine
Transplantation
The New England Journal of Medicine
Bone Marrow Transplantation
Journal of Dermatology
Hematology/Oncology Clinics of North America
The New England Journal of Medicine
Transplantation
Transplantation Proceedings
Journal of the American Dietetic Association
Bone Marrow Transplantation
[Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Annals of Internal Medicine
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
British Journal of Haematology
The New England Journal of Medicine
Nci Monographs : a Publication of the National Cancer Institute
Haematology and Blood Transfusion
Cancer Treatment and Research
Bone Marrow Transplantation
Bone Marrow Transplantation
Bone Marrow Transplantation
Bone Marrow Transplantation
Journal of Allergy and Clinical Immunology
The New England Journal of Medicine
Annals of Internal Medicine
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bone Marrow Transplantation
British Journal of Haematology
Transplantation Proceedings
Transplantation Proceedings
The New England Journal of Medicine
Bone Marrow Transplantation
Bone Marrow Transplantation
Bone Marrow Transplantation
Transplantation Proceedings
Transplantation Proceedings
The New England Journal of Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Allergy and Clinical Immunology
Clinical Transplantation
Transplantation Proceedings
Transplantation Proceedings
Bone Marrow Transplantation
European Journal of Haematology. Supplementum
Journal of Allergy and Clinical Immunology
Progress in Clinical and Biological Research
Progress in Clinical and Biological Research
European Journal of Haematology, Supplement
Bone Marrow Transplantation
Bone Marrow Transplantation
Bone Marrow Transplantation
Blood
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bone Marrow Transplantation
Bone Marrow Transplantation
Concepts in Immunopathology
Bone Marrow Transplantation
Annals of Internal Medicine
Annals of Internal Medicine
The American Journal of Medicine
Bone Marrow Transplantation
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bone Marrow Transplantation
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Archives of Pathology & Laboratory Medicine
Bone Marrow Transplantation
Experimental Hematology
Transplantation Proceedings
Progress in Clinical and Biological Research
Progress in Clinical and Biological Research
Progress in Clinical and Biological Research
Bone Marrow Transplantation
Transplantation
Bone Marrow Transplantation
Annals of Internal Medicine
The New England Journal of Medicine
Gastroenterology
Transplantation Proceedings
International Journal of Cell Cloning
International Journal of Cell Cloning
International Journal of Cell Cloning
International Journal of Cell Cloning
The Journal of Infectious Diseases
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Transplantation
The American Journal of Medicine
The American Journal of Medicine
Laboratory Investigation
Leukemia Research
Medical and Pediatric Oncology
Lancet (London, England)
American Journal of Hematology
Archives of Internal Medicine
International Journal of Radiation Oncology, Biology, Physics
The American Review of Respiratory Disease
The American Journal of Medicine
Ajr. American Journal of Roentgenology
Transplantation
Seminars in Hematology
Seminars in Hematology
Human Immunology
Cancer Investigation
British Journal of Haematology
Transplantation
Clinics in Haematology
The Journal of Infectious Diseases
Transplantation
Archives of Ophthalmology (Chicago, Ill. : 1960)
Transplantation
Annals of Internal Medicine
The New England Journal of Medicine
Immunology Today
Hematological Oncology
Obstetrics and Gynecology
Lancet (London, England)
Annals of Internal Medicine
Lancet (London, England)
Transplantation
Transplantation
Leukemia Research
Leukemia Research
Leukemia Research
Leukemia Research
Leukemia Research
Human Pathology
Transplantation Proceedings
The New England Journal of Medicine
Transplantation Proceedings
The American Journal of Medicine
Archives of Internal Medicine
The American Journal of Pathology
Annals of the Rheumatic Diseases
Bone Marrow Transplant
Jnccn Journal of the National Comprehensive Cancer Network
Biol Blood Marrow Transplant
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Arthritis and Rheumatism
Arthritis and Rheumatism
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Scleroderma: From Pathogenesis to Comprehensive Management
Hematopoietic Stem Cell Transplantation
Offices & Contact
Durham, NC
27710 Cellular Therapy Abmt, Box 3961 DUMC
Durham, NC
27705