Peter Fecci
Professor of Neurosurgery
Overview
As the Director of both the Brain Tumor Immunotherapy Program and the Center for Brain and Spine Metastasis at Duke University, I focus our programmatic interests on the design, optimization, and monitoring of immune-based treatment platforms for patients with intracranial tumors, whether primary or metastatic. Within this broad scope, however, my own group looks more specifically at limitations to immunotherapeutic success, with a particular focus on understanding and reversing T cell dysfunction in patients with glioblastoma (GBM) and brain metastases. We employ a systematic approach to categorizing T cell dysfunction (Woroniecka et al, Clin Cancer Res 2018 Aug 15;24(16):3792-3802), and whereas our earlier work addressed concerns for regulatory T cell-induced tolerance, we now heavily study T cell ignorance and exhaustion, as well. Regarding the former, we recently published the novel phenomenon of S1P1-mediated bone marrow T cell sequestration in patients with intracranial tumors (Chongsathidkiet et al, Nat Medicine 2018 Sep;24(9):1459-1468). Regarding the latter, we have likewise recently identified and characterized exhaustion as a significant limitation to T-cell function within GBM (Woroniecka et al, Clin Cancer Res 2018 Sep 1;24(17):4175-4186). I very much look to collaboratively integrate our approaches with others investigating innovative treatment options. I continue my focus on combining strategies for reversing T cell deficits with current and novel immune-based platforms as a means of deriving and improving rational and precise anti-tumor therapies. It is my sincerest desire to forge a career focused on co-operative, multi-disciplinary, organized brain tumor therapy. Ultimately, my goal is to help coordinate the efforts of a streamlined and effective center for brain tumor research and clinical care. I hope to play some role in ushering in a period where the science and treatment arms of brain tumor therapy suffer no disjoint, but instead represent the convergent efforts of researchers, neuro-oncologists, medical oncologists, radiation oncologists, biomedical engineers, and neurosurgeons alike. I hope to see such synergy become standard of care.
Positions
Professor of Neurosurgery in the School of Medicine
2022 School of Medicine
Associate Professor of Biomedical Engineering in the Pratt School of Engineering
2021 Pratt School of Engineering
Associate Professor in Integrative Immunobiology in the School of Medicine
2020 School of Medicine
Professor in Pathology in the School of Medicine
2022 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2015 School of Medicine
Education
M.D. 2007
2007 Duke University School of Medicine
Ph.D. 2007
2007 Duke University
Internship, General Surgery
2008 Massachusetts General Hospital
Residency, Neurosurgery
2013 Massachusetts General Hospital
Postdoctoral Fellow
2012 Dana-Farber Cancer Institute
Publications, Grants & Awards
- Grants (25)
- Awards (18)
- Academics Articles (126)
- Conference Pages (77)
- Book Sections (9)
National Institutes of Health
National Institutes of Health
Monteris Medical, Inc.
National Institutes of Health
National Institutes of Health
Cancer Research Institute
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
University of North Carolina - Chapel Hill
National Institutes of Health
Sontag Foundation
Charlie Teo Foundation
Monteris Medical, Inc.
National Institutes of Health
University of North Carolina - Chapel Hill
Department of Defense
National Institutes of Health
National Institutes of Health
Department of Defense
Sontag Foundation
Monteris Medical, Inc.
Minnetronix, Inc
American Association of Physicists in Medicine
National Institutes of Health
Duke University School of Medicine
Prince Mahidol Award Foundation
Alpha Omega Alpha Medical Honor Society
Duke University Department of Neurosurgery
Sontag Foundation
New England Neurosurgical Society
Congress of Neurological Surgeons
National Institutes of Health
Tufts University School of Medicine
Duke University Department of Neurosurgery
Society for Neuro-Oncology
Duke University School of Medicine
National Institutes of Health
Cornell University
Cornell University
Duke University School of Medicine
World Neurosurg
Nature Cancer
Clinical Cancer Research
Int J Radiat Oncol Biol Phys
Neuro Oncology Practice
Advances in Radiation Oncology
Advances in Radiation Oncology
Neuro Oncology Advances
Neuro Oncology Advances
Surgical Neurology International
Nature Communications
Adv Drug Deliv Rev
Hematol Oncol Clin North Am
Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics
Neuro Oncology Advances
Neuro Oncology Advances
Frontiers in Oncology
J Immunol Methods
Clinical Cancer Research
J Pain Symptom Manage
Neuro Oncology Advances
Neuro Oncol
Neuro Oncology Practice
Clinical Cancer Research
J Neurooncol
J Neurooncol
Frontiers in Oncology
Frontiers in Immunology
Advances in Radiation Oncology
Frontiers in Oncology
World Neurosurg
Neuro Oncology Practice
Epilepsy Res
Journal for Immunotherapy of Cancer
Int J Hyperthermia
Expert Opin Biol Ther
Clinical Cancer Research
Clinical Cancer Research
J Clin Invest
Nat Rev Cancer
Int J Radiat Oncol Biol Phys
Clinical Cancer Research
Immunotherapy
Nat Biotechnol
Journal of Neurological Surgery Part B: Skull Base
Clinical Cancer Research
J Radiosurg Sbrt
Oncotarget
J Clin Neurosci
Clinical Cancer Research
Clinical Cancer Research
World Neurosurg
Journal for Immunotherapy of Cancer
Int J Radiat Oncol Biol Phys
Int J Radiat Oncol Biol Phys
Methods Mol Biol
Oncoimmunology
Sage Open Medical Case Reports
Expert Opin Biol Ther
Expert Opin Drug Saf
Advances in Radiation Oncology
Int J Radiat Oncol Biol Phys
Oncoimmunology
Nature Communications
J Neurosurg
Neuro Oncol
J Neurooncol
Oncoimmunology
Surgical Neurology International
Clinical Cancer Research
Oncoimmunology
Cancer Discov
Proc Natl Acad Sci U S A
Expert Rev Vaccines
Clinical Cancer Research
Neurosurgery
Journal of Emergency Medicine
Neurosurgical Review
Immunol Rev
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Cancer Research
Cancer Journal (Sudbury, Mass.)
Journal of Neuro Oncology
Neuroimaging Clinics of North America
Neuroimaging Clinics of North America
Neuro Oncology
The Journal of Immunology
The Journal of Immunology
Advances in Radiation Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Neuro Oncology
International Journal of Radiation Oncology, Biology, Physics
International Journal of Radiation Oncology, Biology, Physics
International Journal of Radiation Oncology, Biology, Physics
International Journal of Radiation Oncology, Biology, Physics
Cancer Research
Neuro Oncology
International Journal of Radiation Oncology, Biology, Physics
Neuro Oncology
Neuro Oncology
Cancer Research
Journal of Neurosurgery
Progress in Biomedical Optics and Imaging Proceedings of Spie
International Journal of Radiation Oncology, Biology, Physics
International Journal of Radiation Oncology, Biology, Physics
International Journal of Radiation Oncology, Biology, Physics
Neuro Oncology
The Journal of Immunology
The Journal of Immunology
The Journal of Immunology
Neuro Oncology
Neuro Oncology
International Journal of Radiation Oncology, Biology, Physics
Journal of Neurosurgery
Journal of Neurosurgery
Journal of Neuropathology and Experimental Neurology
The Journal of Immunology
Progress in Biomedical Optics and Imaging Proceedings of Spie
Neurosurgery
Neuro Oncology
Neuro Oncology
International Journal of Radiation Oncology, Biology, Physics
Neurosurgery
Journal of Neurosurgery
Journal of Neurosurgery
Neuro Oncology
International Journal of Radiation Oncology, Biology, Physics
Neurosurgery
Medical Physics
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Neurosurgery
Journal of Neurosurgery
Journal of Neurosurgery
Cancer Research
Neuro Oncology
Neuro Oncology
Neuro Oncology
International Journal of Radiation Oncology, Biology, Physics
Journal of Neurosurgery
Neurosurgery
Neuro Oncology
Journal of Neurosurgery
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Handbook of Neuro-Oncology Neuroimaging
Immunotherapeutic Strategies for the Treatment of Glioma
Central Nervous System Metastases: Diagnosis and Treatment
Translational Immunotherapy of Brain Tumors
The Duke Glioma Handbook: Pathology, Diagnosis, and Management
NEURO-ONCOLOGY: THE ESSENTIALS, 3RD EDITION
ADVANCED VACCINE RESEARCH: METHODS FOR THE DECADE OF VACCINES
DCI Centers, Cancer Types & Labs
Offices & Contact
Durham, NC
27710