Smita Nair
Professor in Surgery
Overview
I have 22 years of experience in the field of cancer vaccines and immunotherapy and I am an accomplished T cell immunologist. Laboratory website:
https://surgery.duke.edu/immunology-inflammation-immunotherapy-laboratory
Current projects in the Nair Laboratory:
1] Dendritic cell vaccines using tumor-antigen encoding RNA (mRNA, total tumor RNA, amplified tumor mRNA)
2] Local immune receptor modulation using mRNA that encodes for antibodies, receptor-ligands, cytokines, chemokines and toll-like receptors (current target list: CTLA4, GITR, PD1, TIM3, LAG3, OX40 and 41BB)
3] Combination therapies for cancer: cytotoxic therapy (radiation, chemo and oncolytic poliovirus therapy) with dendritic cell-based vaccines and immune checkpoint blockade
4] Adoptive T cell therapy using tumor RNA-transfected dendritic cells to expand tumor-specific T cells ex vivo
5] Adoptive T cell therapy using PSMA CAR (chimeric antigen receptor) RNA-transfected T cells
6] Direct injection of tumor antigen encoding RNA (targeting antigens to dendric cells in vivo using nanoparticles and aptamers)
Positions
Professor in Surgery in the School of Medicine
2021 School of Medicine
Professor in Pathology in the School of Medicine
2020 School of Medicine
Professor in Neurosurgery in the School of Medicine
2020 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1993 School of Medicine
Education
Ph.D. 1993
1993 University of Tennessee Knoxville
Publications, Grants & Awards
- Grants (37)
- Academics Articles (149)
- Conference Pages (25)
- Book Sections (2)
National Institutes of Health
National Institutes of Health
National Institutes of Health
Department of Defense
National Institutes of Health
National Institutes of Health
National Institutes of Health
Department of Defense
Melanoma Research Alliance
Department of Defense
National Institutes of Health
Department of Defense
National Institutes of Health
National Institutes of Health
National Cancer Center
National Institutes of Health
National Institutes of Health
National Institutes of Health
United States Army Medical Research Acquisition Activity
National Institutes of Health
National Institutes of Health
Department of Defense
Department of Defense
Department of Defense
National Institutes of Health
Alliance for Cancer Gene Therapy
North Carolina Biotechnology Center
National Institutes of Health
National Institutes of Health
Department of Defense
National Institutes of Health
Department of Defense
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Journal for Immunotherapy of Cancer
Sci Transl Med
Plant Cell, Tissue and Organ Culture
Frontiers in Immunology
Nucleic Acid Ther
Critical Care Explorations
Annals of Surgical Oncology
Cancers
Journal for Immunotherapy of Cancer
Nanotechnology
International Journal of Molecular Sciences
Advanced Science (Weinheim, Baden Wurttemberg, Germany)
J Control Release
Front Biosci (Landmark Ed)
Molecular Therapy : the Journal of the American Society of Gene Therapy
Methods Mol Biol
Frontiers in Immunology
Molecular Therapy. Nucleic Acids
Annals of Surgical Oncology
Science Advances
Molecular Therapy : the Journal of the American Society of Gene Therapy
Journal for Immunotherapy of Cancer
Nature Communications
Cancer Immunol Immunother
Nature Communications
J Clin Invest
Nature Communications
Journal for Immunotherapy of Cancer
Frontiers in Immunology
Clin Breast Cancer
The New England Journal of Medicine
Indian Pediatr
Indian Pediatrics
Annu Rev Med
J Control Release
Sci Transl Med
Clinical Cancer Research
Discov Med
Cancer Immunology Research
J Immunol Res
Methods Mol Biol
Stem Cells Dev
J Control Release
J Immunol Res
Scientific Reports
Adv Healthc Mater
Clinical Cancer Research
Scientific Reports
Clinical Cancer Research
Methods in Molecular Biology (Clifton, N.J.)
The Journal of Clinical Investigation
Journal of Translational Medicine
J Control Release
Nucleic Acid Ther
Methods Mol Biol
Methods Mol Biol
Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]
European Journal of Immunology
Expert Opin Biol Ther
Cancer Gene Ther
Chemistry & Biology
Hum Gene Ther
Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Cancer Immunology, Immunotherapy
Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
The Journal of Immunology
The Journal of Immunology
Cancer Investigation
Expert Review of Vaccines
Annals of Surgery
International Journal of Gastrointestinal Cancer
The Journal of Immunology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
The Journal of Clinical Investigation
The Journal of Immunology
The Journal of Immunology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
The Journal of Immunology
Current Opinion in Molecular Therapeutics
Journal of Immunotherapy (Hagerstown, Md. : 1997)
International Journal of Cancer
The Journal of Immunology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Cancer Research
European Journal of Immunology
Cancer Immunology, Immunotherapy
Nature Biotechnology
European Journal of Immunology
Journal of Immunotherapy (Hagerstown, Md. : 1997)
Current Topics in Microbiology and Immunology
The Journal of Experimental Medicine
International Journal of Cancer
European Journal of Immunology
The Journal of Experimental Medicine
The Journal of Immunology
International Immunology
Journal of Leukocyte Biology
Journal of Virology
Journal of Virology
Journal of Virology
Journal of Immunological Methods
Seminars in Immunology
The Journal of Immunology
The Journal of Experimental Medicine
Annals of Surgical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Immunology Research
Cancer Research
The Journal of Immunology
The Journal of Immunology
Cancer Research
Cancer Immunology Research
The Journal of Immunology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Molecular Therapy
Molecular Therapy
Cancer Gene Therapy
Journal of Leukocyte Biology
Annals of Oncology
Journal of Leukocyte Biology
Journal of Leukocyte Biology
Journal of Leukocyte Biology
Cancer Gene Therapy
Omics in Horticultural Crops
Cancer Vaccines: From Research to Clinical Practice
DCI Centers, Cancer Types & Labs
Offices & Contact
Durham, NC
27710 Room 1077, Msrb-2, 106 Research Drive
Durham, NC
27710