Timothy Haystead
Professor of Pharmacology and Cancer Biology
Overview
Haystead, Timothy. Using chemical biology approaches to define novel drug targets for the treatment of hypertension, obesity, cancer, inflammatory and infectious disease.
Research Interests
The major focus of my laboratory is the discovery and development of novel small molecule inhibitors targeting purine-utilizing proteins involved in various aspects of human disease. Specific targets of interest include heat shock protein 90 (Hsp90), heat shock protein 70 (Hsp70), fatty acid synthase, acetyl CoA Carboxylase, DAPK3 (ZIPK), PIM kinases, dengue fever non-structural protein 5 (NS5) and TAK1 (haysteadlab.com). Hsp90, Hsp70 and fatty acid synthase all have cancer and antiviral therapeutic indications and we are actively developing a series molecules specifically targeting these proteins that were scratch discovered in our laboratory. We have also developed a series of novel imaging molecules based on our Hsp90 inhibitor series that have utility as both diagnostics and potentially curative strategies for a number human cancers and viral infections. Our DAPK(ZIPK) and PIMK inhibitors have shown indications as anti-hypertensive agents as well as having utility in preventing reperfusion injury after stroke. Our TAK1 inhibitor program (discovered with the Derbyshire Laboratory, Department of Chemistry, Duke) has defined a highly potent and selective inhibitor of TAK1 kinase an important protein kinases thought to mediate the actions of proinflammatory cytokines such as TNFa, IL1 and TGFb. The foundations of these programs are based on the development a chemoproteomic strategy utilizing affinity methods combined with in house organic synthetic chemistry.
Positions
Professor of Pharmacology and Cancer Biology in the School of Medicine
2015 School of Medicine
Associate Professor in Pathology in the School of Medicine
2002 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2000 School of Medicine
Education
Ph.D. 1988
1988 University of Dundee (United Kingdom)
Publications, Grants & Awards
- Grants (38)
- Academics Articles (201)
- Conference Pages (6)
- Book Sections (1)
National Institutes of Health
Steven & Alexandra Cohen Foundation
National Institutes of Health
Bay Area Lyme Foundation
University of Arkansas for Medical Sciences
Bill & Marian Cook Foundation
Department of Defense
Eydis Bio Inc.
Open Philanthropy Project
Open Philanthropy Project
Eydis Bio Inc.
Good Ventures Foundation
National Institutes of Health
North Carolina Biotechnology Center
National Institutes of Health
National Institutes of Health
American Society for Pharmacology and Experimental Therapeutics
National Institutes of Health
Department of Defense
National Institutes of Health
Open Philanthropy Project
Open Philanthropy Project
Department of Defense
National University of Singapore
National Institutes of Health
National Institutes of Health
Ohio State University
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Cell Chem Biol
Pharmacology Research & Perspectives
Jci Insight
Exp Physiol
Scientific Reports
Journal for Immunotherapy of Cancer
Mol Cell Endocrinol
Acs Chem Biol
Mol Cancer Ther
The Journal of Biological Chemistry
Nat Struct Mol Biol
Biomedical Optics Express
The Journal of Biological Chemistry
Sci Transl Med
Open Biology
Communications Biology
The Journal of Biological Chemistry
Arthritis Research & Therapy
Arch Biochem Biophys
Scientific Reports
Cell Reports
Scientific Reports
Scientific Reports
Cell Chem Biol
Cell Stress Chaperones
Antimicrob Agents Chemother
Eur Respir J
Methods Mol Biol
Clinical Cancer Research
Scientific Reports
Cell Reports
Scientific Reports
Cell Chem Biol
Acs Chem Biol
Future Virology
Acs Chem Biol
Nature Communications
Cell Chem Biol
Cell Reports
The Journal of Biological Chemistry
Chemistry & Biology
Acs Chem Biol
The Journal of Cell Biology
Chemistry & Biology
Cell Host Microbe
Breast Cancer Research : Bcr
Methods Mol Biol
The Journal of Biological Chemistry
Nucleic Acids Res
Hypertension
The Journal of Biological Chemistry
Chemistry & Biology
Mol Cell Biochem
The Journal of Biological Chemistry
Trends in Parasitology
Molecular & Cellular Proteomics : Mcp
Nucleosides Nucleotides Nucleic Acids
The Journal of Biological Chemistry
Hybridoma (2005)
Journal of Proteome Research
Proceedings of the National Academy of Sciences of the United States of America
Cellular Signalling
The Journal of Biological Chemistry
Molecular Microbiology
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Methods in Molecular Biology (Clifton, N.J.)
Methods in Molecular Biology (Clifton, N.J.)
Cellular Signalling
The Journal of Clinical Investigation
Molecular Biology of the Cell
Expert Rev Proteomics
Current Topics in Medicinal Chemistry
Cellular Signalling
Molecular Biology of the Cell
Molecular and Cellular Biochemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Ajr. American Journal of Roentgenology
Molecular and Cellular Proteomics
Febs Letters
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Biochemistry
Nucleic Acids Res
European Journal of Biochemistry
Trends in Pharmacological Sciences
Biology of Reproduction
The Journal of Biological Chemistry
Recent Progress in Hormone Research
Methods in Enzymology
Methods in Enzymology
Molecular Pharmacology
The Biochemical Journal
The Journal of Biological Chemistry
Molecular and Cellular Proteomics
Microbiology and Molecular Biology Reviews : Mmbr
Molecular Pharmacology
Molecular and Cellular Proteomics
Biology of Reproduction
Nature Cell Biology
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Arteriosclerosis, Thrombosis, and Vascular Biology
Febs Letters
Proceedings of the National Academy of Sciences of the United States of America
Molecular and Cellular Biology
Molecular and Cellular Biology
The Journal of Biological Chemistry
Biophysical Journal
Molecular Biology of the Cell
Proceedings of the National Academy of Sciences of the United States of America
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Natural Product Letters
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Biophysical Journal
The American Journal of Physiology
Advances in Enzyme Regulation
The Journal of Biological Chemistry
European Journal of Biochemistry
Biophysical Journal
American Journal of Physiology. Cell Physiology
The American Journal of Physiology
British Journal of Pharmacology
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Physiology
Analytical Biochemistry
Medical Science Research
The Journal of Biological Chemistry
Science (New York, N.Y.)
The Journal of Biological Chemistry
European Journal of Biochemistry
The Journal of Biological Chemistry
European Journal of Biochemistry
Febs Letters
Journal of Cellular Biochemistry
Proceedings of the National Academy of Sciences of the United States of America
Advances in Second Messenger and Phosphoprotein Research
Science (New York, N.Y.)
The Biochemical Journal
The Journal of Biological Chemistry
Methods in Enzymology
The Journal of Biological Chemistry
European Journal of Biochemistry
Nature
Journal of Craniofacial Genetics and Developmental Biology
European Journal of Biochemistry
European Journal of Biochemistry
Faseb Journal
Faseb Journal
Archives Internationales De Physiologie Et De Biochimie
The Biochemical Journal
Biochemical Society Transactions
The Biochemical Journal
Pharmacology, Biochemistry, and Behavior
Pharmacology, Biochemistry, and Behavior
Psychopharmacology
Pharmacology, Biochemistry, and Behavior
Psychopharmacology
Optics Infobase Conference Papers
Progress in Biomedical Optics and Imaging Proceedings of Spie
In Vitro Cellular & Developmental Biology Animal
Molecular Cancer Therapeutics
Biology of Reproduction
International Congress Series
Cell Biology: A Laboratory Handbook
Offices & Contact
Durham, NC
27708 Duke Box 3813
Durham, NC
27710