William Kraus
Richard and Pat Johnson University Distinguished Professor
Overview
My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation. My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes. My research space has both a basic wet laboratory component and a human integrative physiology one.
One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).
A second focus of my research group is exploration of genetic determinates of disease risk in human subjects. We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome. We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.
A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.
Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes. We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses. We call this Lifestyle Medicopharmacogenetics.
KEY WORDS:
exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine
Positions
Richard and Pat Johnson University Distinguished Professor in the School of Medicine
2017 School of Medicine
Professor of Medicine in the School of Medicine
2006 School of Medicine
Professor in the School of Nursing in the School of Nursing
2007 School of Nursing
Member of Duke Molecular Physiology Institute in the School of Medicine
2013 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2015 School of Medicine
Education
M.D. 1982
1982 Duke University
Medical Resident, Medicine
1986 Duke University
Fellow in Cardiology, Medicine
1988 Duke University
Publications, Grants & Awards
- Grants (97)
- Academics Articles (603)
- Conference Pages (125)
- Book Sections (11)
National Institutes of Health
American Heart Association
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
American Heart Association
National Institutes of Health
National Institutes of Health
University of South Carolina
Tufts Medical Center
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Florida Hospital
National Institutes of Health
National Institutes of Health
National Institutes of Health
Columbia University
National Institutes of Health
National Institutes of Health
Liposcience Inc.
U.S. Highbush Blueberry Council
American Society of Hematology
Dementia Alliance of North Carolina
National Institutes of Health
National Institutes of Health
GlaxoSmithKline
University of Alabama at Birmingham
Gilead Sciences, Inc.
National Institutes of Health
National Institutes of Health
National Institutes of Health
Environmental Protection Agency
Health Effects Institute
Environmental Protection Agency
National Institutes of Health
GlaxoSmithKline
National Institutes of Health
Bioiberica, S.A.
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Valencell, INC
Environmental Protection Agency
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Cancer Institute
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Aeronautics and Space Administration
National Institutes of Health
National Aeronautics and Space Administration
National Aeronautics and Space Administration
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Aeronautics and Space Administration
National Aeronautics and Space Administration
National Institutes of Health
National Aeronautics and Space Administration
J Cardiopulm Rehabil Prev
Circulation
J Cardiopulm Rehabil Prev
International Journal of Molecular Sciences
Nature Metabolism
Obesity (Silver Spring)
The Lancet Healthy Longevity
Circulation
Circulation
Journal of the American Heart Association
J Clin Hypertens (Greenwich)
J Alzheimers Dis
Translational Journal of the American College of Sports Medicine
Frontiers in Sports and Active Living
Frontiers in Physiology
J Gerontol a Biol Sci Med Sci
Journal of Cardiac Failure
Physiological Reports
Scientific Reports
Health Psychology
Circulation. Genomic and Precision Medicine
Journal of Cardiovascular Development and Disease
American Heart Journal
American Heart Journal
Ieee J Biomed Health Inform
Sports Med Open
Exp Gerontol
J Biol Rhythms
Scientific Reports
Curr Sports Med Rep
Am Heart J Plus
J Aging Phys Act
The Lancet. Public Health
J Tissue Eng Regen Med
Elife
Nature Communications
American Heart Journal
Bmj Open Diabetes Research & Care
J Alzheimers Dis
Translational Journal of the American College of Sports Medicine
Support Care Cancer
The American Journal of Clinical Nutrition
Journal of the American Geriatrics Society
Curr Sports Med Rep
J Cardiovasc Transl Res
Journal of Cardiac Failure
Cardiovascular Diabetology
Curr Sports Med Rep
Arthritis Research & Therapy
Science
J Cardiopulm Rehabil Prev
Environmental Epidemiology (Philadelphia, Pa.)
Curr Sports Med Rep
Genome Medicine
Environ Pollut
J Appl Physiol (1985)
European Heart Journal
American Heart Journal
Exerc Sport Sci Rev
Frontiers in Physiology
Frontiers in Cardiovascular Medicine
Frontiers in Genetics
Frontiers in Genetics
Frontiers in Cardiovascular Medicine
Frontiers in Sports and Active Living
Scientific Reports
Circ Heart Fail
Am J Prev Cardiol
Osteoarthr Cartil Open
Cell Reports
Translational Psychiatry
The International Journal of Behavioral Nutrition and Physical Activity
Med Sci Sports Exerc
Journal of the American Geriatrics Society
Jacc Heart Fail
Frontiers in Immunology
J Alzheimers Dis
Frontiers in Sports and Active Living
Aims Bioengineering
Ssm Population Health
Jacc Heart Fail
Journal of the American Heart Association
Journal of the American Heart Association
Lancet Diabetes Endocrinol
Genome Biology
Ann Biomed Eng
Med Sci Sports Exerc
Med Sci Sports Exerc
Med Sci Sports Exerc
Med Sci Sports Exerc
Med Sci Sports Exerc
Med Sci Sports Exerc
Med Sci Sports Exerc
American Heart Journal
J Gerontol a Biol Sci Med Sci
The American Journal of Clinical Nutrition
Environmental Epidemiology (Philadelphia, Pa.)
J Am Coll Cardiol
Neurology
Eur J Heart Fail
Frontiers in Physiology
Frontiers in Immunology
J Alzheimers Dis
Frontiers in Physiology
Journal of Clinical Lipidology
Frontiers in Physiology
Arthritis Research & Therapy
J Phys Act Health
Jacc Heart Fail
American Heart Journal
Particle and Fibre Toxicology
Atherosclerosis
Nucleic Acids Res
Molecular Therapy : the Journal of the American Society of Gene Therapy
Eur J Heart Fail
Health Psychology
Circulation Research
Stem Cell Reports
Bmc Research Notes
Journal of the American Geriatrics Society
Circulation Cardiovascular Quality and Outcomes
Arthritis Research & Therapy
Nature Communications
Clinical Kidney Journal
Med Sci Sports Exerc
American Heart Journal
Journal of the American Heart Association
Journal of the American Heart Association
Arterioscler Thromb Vasc Biol
Journal of the American Heart Association
Journal of Personalized Medicine
Arterioscler Thromb Vasc Biol
Plos One
Frontiers in Physiology
Bmj Open Diabetes Research & Care
Frontiers in Genetics
J Gerontol a Biol Sci Med Sci
Journal of Functional Morphology and Kinesiology
Environmental Health
Nature Communications
Environ Res
Med Sci Sports Exerc
Jmir Research Protocols
American Heart Journal
American Heart Journal
Journal of the American Heart Association
The New England Journal of Medicine
Nature Communications
American Heart Journal
J Expo Sci Environ Epidemiol
J Am Coll Cardiol
J Gerontol a Biol Sci Med Sci
The American Journal of Clinical Nutrition
Tissue Eng Part C Methods
Pulmonary Circulation
J Am Coll Cardiol
Lipids in Health and Disease
Cardiorenal Medicine
Arthritis Research & Therapy
American Heart Journal
Psychosom Med
Oxid Med Cell Longev
Frontiers in Endocrinology
Contemporary Clinical Trials Communications
Current Cardiology Reports
Med Sci Sports Exerc
J Gerontol a Biol Sci Med Sci
Jacc Heart Fail
Journal of the American Heart Association
Med Sci Sports Exerc
Journal of Cardiac Failure
Jama
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
The New England Journal of Medicine
Curr Heart Fail Rep
The New England Journal of Medicine
Med Sci Sports Exerc
Med Sci Sports Exerc
Journal of the American College of Cardiology
Arthritis Research & Therapy
Circulation
Tissue Eng Part A
American Heart Journal
The New England Journal of Medicine
J Am Coll Cardiol
J Gerontol a Biol Sci Med Sci
Environ Res
J Am Coll Cardiol
Med Sci Sports Exerc
Bmj Open Sport — Exercise Medicine
Atherosclerosis
J Cardiovasc Transl Res
American Heart Journal
Arthritis & Rheumatology
Environ Health Perspect
Genome Biology
J Gerontol a Biol Sci Med Sci
Genetic Epidemiology
American Heart Journal
Heart Surg Forum
J Heart Lung Transplant
Cell Metab
Circ Heart Fail
J Appl Physiol (1985)
Med Sci Sports Exerc
European Journal of Human Genetics : Ejhg
American Heart Journal
Heart Surg Forum
Nature
Circ Cardiovasc Genet
Journal of Cardiac Failure
Circ Heart Fail
Scandinavian Journal of Rheumatology
Pharmacogenomics
Plos One
Diabetes Obes Metab
Circulation
Pharmacogenomics
Journal of Cardiovascular Translational Research
The Journal of Rheumatology
Circ Cardiovasc Genet
J Cardiovasc Transl Res
Journal of Clinical Oncology
Jacc Heart Fail
The Journal of Nutrition
Am J Physiol Heart Circ Physiol
Journal of Personalized Medicine
Am J Physiol Cell Physiol
American Heart Journal
Med Sci Sports Exerc
The American Journal of Clinical Nutrition
Journal of Cardiac Failure
J Cardiopulm Rehabil Prev
J Diabetes Complications
Journal of Diabetes and Its Complications
Plos One
Med Sci Sports Exerc
Hum Mol Genet
Circ Heart Fail
Int J Cardiol
J Am Coll Cardiol
Contemp Clin Trials
American Heart Journal
European Heart Journal
J Gerontol a Biol Sci Med Sci
Global Advances in Health and Medicine
Integr Cancer Ther
Journal of Women'S Health (2002)
Eur J Heart Fail
Mol Genet Metab
Pediatr Exerc Sci
Contemp Clin Trials
Stem Cell Research & Therapy
J Cardiopulm Rehabil Prev
Frontiers in Genetics
J Appl Physiol (1985)
Bmc Medical Genomics
Circulation
J Am Coll Cardiol
Med Sci Sports Exerc
Exerc Sport Sci Rev
J Appl Physiol (1985)
Journal of General Internal Medicine
American Heart Journal
Osteoarthritis Cartilage
J Cardiovasc Transl Res
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
American Heart Journal
Circ Cardiovasc Genet
The Journal of Thoracic and Cardiovascular Surgery
Int J Sports Med
Am J Physiol Endocrinol Metab
Journal of General Internal Medicine
J Gerontol a Biol Sci Med Sci
Circ Cardiovasc Genet
Arterioscler Thromb Vasc Biol
Am J Physiol Endocrinol Metab
Am J Med
J Appl Physiol (1985)
J Appl Physiol (1985)
Med Sci Sports Exerc
Journal of Cardiac Failure
J Appl Physiol (1985)
J Appl Physiol (1985)
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
J Gerontol a Biol Sci Med Sci
J Appl Physiol (1985)
J Appl Physiol (1985)
Bmc Medical Genomics
The Journal of Clinical Endocrinology and Metabolism
Endocrinology
J Gerontol a Biol Sci Med Sci
Tissue Eng Part A
Circulation
Med Sci Sports Exerc
J Gerontol a Biol Sci Med Sci
The Journal of Cardiovascular Nursing
Circ Cardiovasc Genet
Arthritis Rheum
American Journal of Lifestyle Medicine
J Cardiopulm Rehabil Prev
Obesity (Silver Spring)
Obesity (Silver Spring)
American Heart Journal
Journal of Cardiac Failure
American Heart Journal
American Heart Journal
American Heart Journal
Plos One
Diabetes Care
Med Sci Sports Exerc
Arteriosclerosis, Thrombosis, and Vascular Biology
Med Sci Sports Exerc
Journal of Applied Physiology (Bethesda, Md. : 1985)
Journal of Applied Physiology (Bethesda, Md. : 1985)
Journal of the American College of Cardiology
Journal of the American College of Cardiology
Journal of the American College of Cardiology
Hum Genet
Med Sci Sports Exerc
Physiological Genomics
Molecular Systems Biology
Atherosclerosis
Journal of Health Psychology
Circulation
Psychooncology
Circ Cardiovasc Genet
The American Journal of Cardiology
J Am Coll Cardiol
Aging Clinical and Experimental Research
American Journal of Physiology. Endocrinology and Metabolism
Metabolism: Clinical and Experimental
Annals of Human Genetics
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Bmc Medical Genetics
Metabolism: Clinical and Experimental
Clinical Breast Cancer
Heart Failure Reviews
The American Journal of Cardiology
American Heart Journal
Vascular Medicine
American Heart Journal
Journal of Applied Physiology (Bethesda, Md. : 1985)
Journal of Clinical Oncology
Muscle & Nerve
American Journal of Physiology. Cell Physiology
American Journal of Human Genetics
Obesity (Silver Spring, Md.)
American Heart Journal
Exercise and Sport Sciences Reviews
Annals of Human Genetics
American Heart Journal
Free Radical Biology and Medicine
Medicine and Science in Sports and Exercise
American Heart Journal
American Heart Journal
American Journal of Hematology/ Oncology
Journal of Applied Physiology (Bethesda, Md. : 1985)
The New England Journal of Medicine
Journal of Applied Physiology (Bethesda, Md. : 1985)
Atherosclerosis
Journal of the American Dietetic Association
American Journal of Human Genetics
American Journal of Physiology. Cell Physiology
Archives of Internal Medicine
Journal of Applied Physiology (Bethesda, Md. : 1985)
Journal of Applied Physiology (Bethesda, Md. : 1985)
American Heart Journal
American Heart Journal
The Journal of Physiology
The New England Journal of Medicine
American Heart Journal
Medicine and Science in Sports and Exercise
Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings
American Heart Journal
The New England Journal of Medicine
Cardiology Review
American Heart Journal
American Journal of Physiology. Cell Physiology
American Journal of Physiology. Endocrinology and Metabolism
The Journal of Biological Chemistry
Journal of the National Medical Association
Journal of the American College of Cardiology
Clinical Exercise Physiology
Journal of Biomechanics
Medicine and Science in Sports and Exercise
Clinical Therapeutics
American Heart Journal
In Vitro Cellular & Developmental Biology Animal
Frontiers in Bioscience : a Journal and Virtual Library
Muscle & Nerve
Journal of Applied Physiology (Bethesda, Md. : 1985)
Psychosomatic Medicine
Cell and Tissue Research
The American Journal of Medicine
American Heart Journal
American Heart Journal
American Heart Journal
Medical & Biological Engineering & Computing
Molecular Cell Biology Research Communications : Mcbrc
The American Journal of Cardiology
American Heart Journal
Journal of the American College of Cardiology
The Annals of Thoracic Surgery
Nature Medicine
Nature Medicine
American Journal of Physiology Heart and Circulatory Physiology
The American Journal of Physiology
American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed
Medicine and Science in Sports and Exercise
Proceedings of the Association of American Physicians
Methods in Cell Science
The American Journal of Physiology
Journal of Molecular and Cellular Cardiology
Exercise and Sport Sciences Reviews
Molecular and Cellular Biology
The American Journal of Physiology
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
The American Journal of Physiology
Medicine and Science in Sports and Exercise
The American Journal of Physiology
The Journal of Clinical Investigation
The Journal of Biological Chemistry
The American Journal of Physiology
The American Journal of Physiology
Reviews of Infectious Diseases
Annals of Internal Medicine
The American Journal of Cardiology
Circulation
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Genetic Epidemiology
Medicine and Science in Sports and Exercise
Circulation
Genetic Epidemiology
Journal of Cardiac Failure
Journal of Cardiac Failure
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Circulation Research
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Psychosomatic Medicine
Psychosomatic Medicine
Genetic Epidemiology
Journal of Physical Activity & Health
Genetic Epidemiology
Arthritis & Rheumatology
Arthritis & Rheumatology
Arthritis & Rheumatology
Journal of Cardiac Failure
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Genetic Epidemiology
Arthritis & Rheumatology
European Heart Journal
Journal of Cardiac Failure
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Journal of the American College of Cardiology
Circulation
Circulation Journal : Official Journal of the Japanese Circulation Society
Circulation Journal : Official Journal of the Japanese Circulation Society
Circulation
Journal of Cardiac Failure
Medicine and Science in Sports and Exercise
Journal of the American College of Cardiology
Journal of the American College of Cardiology
Circulation
Medicine and Science in Sports and Exercise
Arthritis and Rheumatism
Arthritis and Rheumatism
Journal of the American College of Cardiology
Arthritis and Rheumatism
Faseb Journal
Journal of the American College of Cardiology
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Medicine and Science in Sports and Exercise
Journal of the American College of Cardiology
Circulation
The American Journal of Cardiology
Diabetes
Circulation
Circulation
Journal of the American College of Cardiology
Journal of the American College of Cardiology
Circulation
Journal of the American College of Cardiology
Journal of the American College of Cardiology
Medicine and Science in Sports and Exercise
Journal of the American College of Cardiology
Contemporary Cardiology
Genomic and Precision Medicine: Cardiovascular Disease: Third Edition
Handbook of Clinical Nutrition and Aging, Third Edition
Food and Nutritional Components in Focus
Heart Failure: A Companion to Braunwald's Heart Disease Expert Consult
Handbook of Clinical Nutrition and Aging
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