Two parents, one holding a toddler, smiling together as the toddler reaches toward the camera.
Arlene Brown, her husband, Richard, and their toddler Andrew.

A Lump, A Life, and a Leap of Faith

Published

For Arlene Brown, when time mattered most, Duke Cancer Institute delivered.

 Portrait of Arlene Brown holding her toddler son, both smiling at the camera.
Arlene Brown and her toddler, Andrew. Photo by Erin Roth.

Arlene Brown knew she was at high risk for breast cancer and stayed vigilant with regular screenings. But nothing could prepare her for the moment she found a lump — while 18 weeks pregnant with her first child.

What followed was a whirlwind of decisions, fears, and a treatment journey that would test her strength and reshape her future.

Brown was named after her Aunt Arlene, who died from triple-negative breast cancer. After Brown’s sister was diagnosed with the same cancer, Brown underwent genetic testing. It revealed that Brown had the BRCA-1 gene mutation, which elevated her risk for breast and ovarian cancer.

Her doctors suggested she undergo a bilateral mastectomy to remove her breasts and an oophorectomy to remove her ovaries. But Brown was 33, and she and her husband, Richard, wanted to start their family.

Instead, she opted for regularly scheduled mammograms and MRIs. The results came back clear, and in December of 2022, the Raleigh, North Carolina, philanthropy officer was thrilled to learn she was pregnant.

In March, after she felt a lump under her right arm during a shower, her doctor advised that lumps and bumps during pregnancy were common. In May, however, Brown had an ultrasound, then a biopsy. Like her family members, Brown was diagnosed with triple-negative breast cancer.

Chemotherapy While Pregnant

Richard Brown playfully lifting toddler Andrew in the air as mom Arlene Brown looks on, smiling.
Arlene Brown, her husband, Richard, and their toddler Andrew. Brown underwent chemotherapy for breast cancer while 27 weeks pregnant. Photo by Erin Roth.

After calling local cancer centers for the first available appointment, Brown chose Duke when they responded quickly. “The oncologist sat my husband and me down and laid out the treatment plan with care and understanding,” she said.

Brown was scared, but medical oncologist Rani Bansal, MD, assured her that pregnant people can tolerate chemotherapy very well and that her baby would continue to grow.

“Many people immediately think they have to terminate the pregnancy or wait until they deliver” to be treated, Bansal said. Instead, the regimen for treating triple-negative breast cancer is modified during pregnancy, and the maternal-fetal medicine team works closely with the patient during her pregnancy to ensure a safe delivery. Brown’s care team also included medical therapists to help her cope with the emotional and mental effects of her diagnosis, and physical therapists who were on standby to help her regain strength and function after delivering her baby.

“They locked arms around us to make sure we were ok,” said Brown, who was 27 weeks pregnant when she started chemotherapy.

Arlene Brown / Breast cancer survivor

A Healthy Baby Boy

Brown’s son, Andrew, arrived healthy after an induction at 35 weeks.

Two weeks later, Brown continued chemotherapy and started immunotherapy, with the goal to destroy all the cancer before surgery.

Brown had a double mastectomy, performed by Duke breast surgeon Maggie DiNome, MD. At the same time, Rebecca Knackstedt, MD, a Duke microvascular surgeon, performed Brown’s breast reconstruction. After surgery, Brown completed five weeks of radiation therapy.

“I had gone back and forth on what I wanted to do when they explained the different options,” Brown said. “I wanted a fast recovery to get back to my newborn. Because my surgeons worked together, it all worked in my favor.”

More than two years after the cancer diagnosis, Andrew is a happy toddler, and Brown continues to heal.

She has done every treatment possible to lower her risk and will be monitored regularly by her doctors for at least five years. So far, she has no sign of recurrence.

When Brown goes to Duke Women’s Cancer Center Raleigh for her follow-up visits, the whole experience “seems like a near-distant memory,” she said.

“I’m glad to be on the other side. And it’s so nice to see friendly, welcoming faces that care about you. I am healing, and I’m grateful.”