NRG-CC008: Ovarian Cancer

What is the Purpose of this Study?

If you choose to join this study, you will be randomly assigned (like a coin flip) to 1 of 2 groups:
- Participants in Group 1 (BLS Group) will have surgery to remove the fallopian tubes and then have a second surgery later to remove the ovaries
- Participants in Group 2 (BSO Group) will have surgery to remove the fallopian tubes and ovaries at the same time

What is the Condition Being Studied?
Ovarian Cancer

Who Can Participate in this Study?

Women ages 35-50 who:

- Have a positive test for BRCA1 mutations

- Have at least one intact ovary and one intact fallopian tube

For more information about who can join this study, please contact the study team at

Age Group
Participating Institutions

What is Involved?

We are doing this study to compare two surgical procedures. We want to know if one procedure is better than the other in terms of lowering the risk of developing ovarian cancer for pre-menopausal women with BRCA1 mutations.

Study Details

Full Title
NRG-CC008, A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers [SOROCk] (NCT # 04251052)
Principal Investigator

Protocol Number

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