What is the Purpose of this Study?
We are doing this study to learn if a combination of chemotherapies and immunotherapies (carboplatin, cabazitaxel, nivolumab and ipilimumab) slows cancer growth in patients with metastatic neuroendocrine or aggressive variant prostate cancer.
We also want to learn about the types of side effects that patients have while they are taking these study drugs together.
Prostate Cancer (Neuroendocrine or Aggressive Variant)
Who Can Participate in the Study?
Adults with neuroendocrine or aggressive variant prostate cancer who:
- Have not already had an immunotherapy drug to treat their cancer
- Have not already had cabazitaxel
What is Involved?
If you join this study you will:
- Get study drugs given to you through a needle in a vein in your arm every 3 weeks
- Have imaging tests
- Have blood and urine tests
- Complete questionnaires