People in the study will get a special medicine called CTIM-76 through a tube in their arm once a week. Each round of treatment lasts 4 weeks. They can keep getting the medicine as long as it helps and doesn’t cause too many problems. Doctors will check on them often with visits, blood tests, and scans to see if the medicine is working and if it’s safe. Some people will start with small doses, and the amount may go up as doctors learn more.

This study is for people who are very sick with certain types of cancer. It includes people with testicular or germ cell tumors, women whose ovarian cancer has come back after regular treatments, and some people with uterine cancer if other treatments didn’t help.

To join the study, people must be 18 years or older. They need to have certain cancers—like ovarian, testicular, or uterine cancer—that came back or kept growing after regular treatments. Their cancer must have a special protein called Claudin-6, except for testicular cancer, which doesn’t need that test. They also need to feel well enough to do everyday things and have healthy blood and organs based on lab tests.

This study is trying out a new medicine called CTIM-76 to see if it’s safe and if it can help treat certain cancers. These cancers have a special protein called Claudin-6. Doctors want to find the best amount of medicine to use and see if it can make the cancer smaller or slow it down.