This study has two parts. The first part is called the Screening Period and lasts about 12 weeks. During this time, people will visit the doctor 5 to 7 times. They will have tests like checking their genes, memory tests, brain scans, a spinal tap, and other exams like blood tests and skin checks.

The second part is called the Study Dosing Period. In this part, people will be randomly chosen to take either a study medicine or a fake pill that looks the same. They will take one pill every day for 5 to 8 years. During this time, they will go to the doctor every few months to answer questions, get exams, and have more tests like brain scans and lab work.

People at risk for developing Alzheimer's disease (people with the APOE4 gene)

This study is for adults who are 40 years old or older. They must have had heart problems before, like a heart attack or needing a stent. They also need to feel worried, stressed, or nervous. People in the study should not already be taking medicine to help their mood, and they should not be part of an exercise program right now.

This study is being done to learn how exercise and medicine can help adults with heart problems feel less worried and stressed. It is important because feeling worried and stressed can make heart problems worse.