This study uses a system called Hemanext ONE that keeps red blood cells in low oxygen. The study lasts about fourteen months. During the study, you will receive two kinds of blood transfusions. One kind uses low oxygen blood, and the other uses regular blood. The order is chosen by chance. Each type of transfusion lasts six months, with a two month break in between. At each visit, doctors will check your vital signs, do blood tests, and ask how you are feeling. There is also an optional visit one day after a transfusion for extra blood tests.

The study looks at people who have blood cancers and need regular blood transfusions.

People can join this study if they have a blood cancer and need regular blood transfusions. They must also be able to have a physical exam and share their medical history during screening, including their height, weight, medicines, and vital signs.

This study is being done to find out if a new way of storing blood, called the Hemanext ONE system, helps red blood cells stay healthier. Researchers want to see if this new method makes the blood work better and maybe reduces the number of transfusions a person needs. The study compares this new type of stored blood with the regular blood that is used today.