Hepatic Artery Chemotherapy for Patients with Localized Pancreas Cancer

What is the Purpose of this Study?

We are doing this study to find out if giving the drugs floxuridine and oxaliplatin directly into the hepatic artery of the liver is a safe and effective option for patients with localized pancreatic ductal adenocarcinoma. This form of drug delivery will be combined with surgery and standard chemotherapy in this study. Chemotherapy can happen either before or after the delivery of drugs directly into the hepatic artery. We also want to see how this regimen works to improve the rate of liver metastasis (cancer that has spread to the liver) after surgery.

What is the Condition Being Studied?

Pancreatic Cancer

Who Can Participate in the Study?

Adults ages 18+ who are diagnosed with localized pancreatic ductal adenocarcinoma.

For more information about who can join this study, please contact the study team at adi.molvin@duke.edu.

Age Group
Adults

What is Involved?

If you choose to join this study, you will:

  • Have a standard-of-care diagnostic laparoscopy (surgery where your doctor looks in your abdomen with a small camera) to confirm you have no additional tumors
  • Have blood draws
  • Have a liver biopsy
  • Have the study drugs (floxuridine and oxaliplatin) delivered directly into the hepatic artery
  • Have surgery to remove your liver tumor (about two weeks after the infusion into your hepatic artery)
  • Have physical exams
  • Have imaging tests (MRI, PET, and/or CT)

Study Details

Full Title
A Window-of-Opportunity Trial Using Neoadjuvant Hepatic Artery Chemotherapy for Patients with Localized Pancreas Cancer
Principal Investigator
Assistant Professor of Surgery
Protocol Number
IRB: PRO00112285
NCT: NCT05634720
Phase
Phase N/A
ClinicalTrials.gov
Enrollment Status
OPEN TO ACCRUAL
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