Eligible participants will receive one extra dose of radiation using Lattice Radiation Therapy (LRT) before starting palliative radiation therapy. Palliative radiation is typically given in 5-10 treatments.

People with large tumors planning to have palliative radiation therapy

Adults with large primary or metastatic tumors (>4.5cm) outside the brain who are planning to have palliative radiation therapy are eligible to participate in this study.

The purpose of this study is to ask if using a specialized radiation therapy technique called Lattice Radiation Therapy (LRT) can shrink large tumors when given with the usual radiation therapy.