PET-CT for Dose Reduced Radiotherapy in HPV-positive Oral Cancer
What is the Purpose of this Study?
We are doing this study to understand whether people who receive a lower radiation dose after an interim (the second scan) PET-CT identifies an early treatment response have a similar outcome to those receiving a standard radiation dose.
The results of the interim PET-CT scan will be used to guide your radiation dose plan. Depending on the PET-CT results, you will either receive a reduced radiation dose or the standard radiation dose for your cancer.
Oral Cancer
Who Can Participate in the Study?
Adults who:
What is Involved?
If you choose to join this study, you will have 2 PET scans in addition to computed tomography (CT) scans.
- The first PET scan will be done with your standard CT scan for treatment planning before starting radiation therapy.
- The second PET-CT scan will be about 2 weeks after starting radiation therapy to see how you are responding.
- You will get either a reduced dose or a standard dose of radiation based on your second PET-CT scan results
Everyone in the study will:
- Be involved in the study for about 1 year
- Have information collected from your medical record for about 2 years
- Have follow up study visits
This study is also available to patients at Duke Raleigh Hospital with eConsent. The 2 PET scans must be done at Duke Cancer Center in Durham, and the rest of your standard medical care will be with your regular doctor at Duke Raleigh Hospital.