If you join this study, you will have the surgery your doctor planned. You can choose to use the regular tool or be randomly picked to use either the regular tool or a new one. Blood will be taken three times (before, during, and after surgery). Doctors will also check your regular cancer visits for one year. The study does not add extra visits or tests.

Some cancers can spread to the thigh bone and make it weak. Doctors may put a metal rod inside the bone to keep it from breaking. Before doing this, they drill the bone, which might push cancer cells into the blood. This study looks at two drilling tools to see which one releases fewer cancer cells during surgery.

Adults 18 and older may join this study if their cancer started in another part of the body, like the breast or lung, and spread to the thigh bone. Their thigh bone must be weak and at risk of breaking, and their doctor must recommend putting in a metal rod. People cannot join if they are under 18, have bone cancer, already broke their thigh bone, or do not need the rod.

This study is testing a special tool called RIA to see if it releases fewer cancer cells into the blood during bone surgery. The RIA washes and suctions while it drills, which may help keep pressure lower in the bone. Doctors will count cancer cells during surgery and watch how the cancer acts over the next year to see if the RIA makes surgery safer.