Study drug RO7589831 for MSI/dMMR solid tumors (BP44474)

What is the Purpose of this Study?

We are doing this study to find out if an experimental drug called RO7589831 (the study drug) is a safe and effective option for cancers with solid tumors. We also want to find out what the best dose of the study drug is in this study.

What is the Condition Being Studied?

Advanced Solid Tumors

Who Can Participate in the Study?

Adults ages 18+ who:

  • Are diagnosed with advanced cancer that worsened after at least 1 prior line of standard therapy
  • Have had a tumor sample test positive for microsatellite instability or mismatch repair deficiency
  • For more information about this study, please contact the study team at 919-668-1861 or

    Age Group

    What is Involved?

    If you choose to join this study, you will:

    • Take the study drug every day (it is taken by mouth)
    • Have your tumor biopsied
    • Give blood and urine samples
    • Have regular CT or MRI scans

    Study Details

    Full Title
    [BP44474] A phase I, open-label study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity of RO7589831 in participants with advanced solid tumors harboring microsatellite instability (MSI) and/or deficient mismatch repair (dMMR)
    Principal Investigator
    Professor of Medicine
    Protocol Number
    IRB: PRO00113812
    NCT: NCT06004245
    Phase I
    Enrollment Status