Study drug RO7589831 for MSI/dMMR solid tumors (BP44474)

What is the Purpose of this Study?

We are doing this study to find out if an experimental drug called RO7589831 (the study drug) is a safe and effective option for cancers with solid tumors. We also want to find out what the best dose of the study drug is in this study.

What is the Condition Being Studied?

Advanced Solid Tumors

Who Can Participate in the Study?

Adults ages 18+ who:
- Are diagnosed with advanced cancer that worsened after at least 1 prior line of standard therapy
- Have had a tumor sample test positive for microsatellite instability or mismatch repair deficiency

For more information about this study, please contact the study team at 919-668-1861 or gi-oncology-cru@dm.duke.edu.

Age Group
Adults

What is Involved?

If you choose to join this study, you will:
- Take the study drug every day (it is taken by mouth)
- Have your tumor biopsied
- Give blood and urine samples
- Have regular CT or MRI scans

Study Details

Full Title
[BP44474] A phase I, open-label study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity of RO7589831 in participants with advanced solid tumors harboring microsatellite instability (MSI) and/or deficient mismatch repair (dMMR)
Principal Investigator
Associate Professor of Medicine
Protocol Number
IRB: PRO00113812
NCT: NCT06004245
Phase
Phase I
ClinicalTrials.gov
Enrollment Status
OPEN TO ACCRUAL
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