We are doing this study to find out if children and young adults with high-grade gliomas who have specific genetic changes (mutations) have better outcomes when they are treated with drugs that "target" those genetic changes. We first need to collect detailed information about the genetic changes within participants' brain tumors. If someone's brain tumor has a targeted genetic change, they may be eligible to participate in a clinical trial with a drug that specifically targets those genetic changes.

High-Grade Gliomas

Children and adults ages 1-39 who:

• Are newly diagnosed with high-grade glioma (diffuse intrinsic pontine glioma [DIPG] are eligible)
• Have no received any previous anticancer therapy for glioma

For more information, contact the study team at 919-684-5301.

If you or your child choose to join this study, you/they will:

• Have a small piece of tumor tissue that was collected during a previous surgery or biopsy sent to a laboratory for genetic testing
• Have a blood draw and/or saliva sample collected for genetic testing