Amanda Hargrove
Professor of Chemistry
Overview
The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “wild West.” Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids. Collaborations with the Department of Biology as well as colleagues in the School of Medicine ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.
Positions
Professor of Chemistry in the Trinity College of Arts & Sciences
2023 Trinity College of Arts & Sciences
Associate Professor of Biochemistry in the School of Medicine
2020 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2013 School of Medicine
Education
B.S. 2004
2004 Trinity University
Ph.D. 2010
2010 University of Texas, Austin
NIH Postdoctoral Fellow, Chemistry
2013 California Institute of Technology
Publications, Grants & Awards
- Grants (24)
- Awards (4)
- Academics Articles (62)
- Conference Pages (2)
- Book Sections (4)
National Institutes of Health
National Institutes of Health
National Institutes of Health
Regents of the University of Michigan
National Science Foundation
National Institutes of Health
National Institutes of Health
Alfred P. Sloan Foundation
National Science Foundation
Prostate Cancer Foundation
National Institutes of Health
Research Corporation for Science Advancement
United States Army Medical Research Acquisition Activity
Regents of the University of Michigan
National Institutes of Health
Research Corporation for Science Advancement
United States Army Medical Research Acquisition Activity
National Institutes of Health
National Institutes of Health
Prostate Cancer Foundation
Department of Education
National Science Foundation
National Institutes of Health
Oak Ridge Associated Universities
American Chemical Society
Alfred P. Sloan Foundation
National Science Foundation (NSF)
Research Corporation for Science Advancement
Nucleic Acids Research
Rna (New York, N.Y.)
Rsc Medicinal Chemistry
Acs Chemical Biology
Rsc Chemical Biology
Acs Chemical Biology
Journal of Medicinal Chemistry
Annals of the New York Academy of Sciences
Cell Chemical Biology
Chemical Communications
Nature Communications
Nucleic Acids Research
Rsc Medicinal Chemistry
Chemical Communications
Medicinal Research Reviews
Acs Chemical Biology
Organic & Biomolecular Chemistry
Methods (San Diego, Calif.)
Acs Chemical Biology
Angewandte Chemie International Edition
Journal of the American Chemical Society
Organic & Biomolecular Chemistry
Angewandte Chemie International Edition
Angewandte Chemie
Nucleic Acids Research
Wiley Interdisciplinary Reviews. Rna
Chemical Communications
Angewandte Chemie
Angewandte Chemie International Edition
Journal of the American Chemical Society
Biochemistry
Monographs in Supramolecular Chemistry
Molecular Cancer Therapeutics
Proceedings of the National Academy of Sciences of the United States of America
Journal of Medicinal Chemistry
Journal of the American Chemical Society
Bioconjugate Chemistry
Organic Letters
New Journal of Chemistry
The Journal of Organic Chemistry
Journal of the American Society for Mass Spectrometry
Tetrahedron Letters
Journal of Porphyrins and Phthalocyanines
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology
The Journal of Biological Chemistry
World Scientific Series in Nanoscience and Nanotechnology
RNA RECOGNITION
DCI Centers, Cancer Types & Labs
Offices & Contact
Durham, NC
27708-0346 3219 French Science Center, Box 90346
Durham, NC
27708