Amanda Hargrove

Professor of Chemistry
Amanda Hargrove
Amanda Hargrove

Overview

The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “wild West.” Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids. Collaborations with the Department of Biology as well as colleagues in the School of Medicine ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.

Positions

Professor of Chemistry in the Trinity College of Arts & Sciences

2023 Trinity College of Arts & Sciences

Associate Professor of Biochemistry in the School of Medicine

2020 School of Medicine

Member of the Duke Cancer Institute in the School of Medicine

2013 School of Medicine

Education

B.S. 2004

2004 Trinity University

Ph.D. 2010

2010 University of Texas, Austin

NIH Postdoctoral Fellow, Chemistry

2013 California Institute of Technology

Publications, Grants & Awards

DCI Centers, Cancer Types & Labs

Offices & Contact

124 Science Drive, Box 90346, 3219 French Sci Center
Durham, NC
27708-0346
3219 French Science Center, Box 90346
Durham, NC
27708