Amy Susanne Gladfelter
Amy Susanne Gladfelter

Amy Susanne Gladfelter

Instructor in the Department of Cell Biology

Overview

I am interested in understanding the fundamental mechanisms of cell organization. I investigate cell cycle control and the septin cytoskeleton. 

I study the spatial organization of multinucleate cells, also called syncytia, which are cells with many nuclei that share a common cytoplasm.  The Gladfelter lab broadly interested in understanding why syncytia have arisen in diverse contexts within the tree of life. Syncytial cells are found throughout the human body, including in bonebloodmuscle, and placental tissue, and throughout the natural world, including in fungialgae and in many animals during their development. Many tumors become syncytial, while certain viruses, including SARS-CoV-2, can induce cells to fuse.  Additionally, I study the assembly of the septin cytoskeleton and how aberrant septin structure affects its function. My research program uses microscopy, biophysical and genetic approaches to study cell biology.

Also, I am a Fellow and co-director of the Physiology course at the Marine Biological Laboratory (MBL) Woods Hole, MA 

Positions

Instructor in the Department of Cell Biology in the School of Medicine

2023 School of Medicine

Member of the Duke Cancer Institute in the School of Medicine

2023 School of Medicine

Education

Ph.D. 2001

2001 Duke University

Publications, Grants & Awards