Anna Mae Diehl
Anna Mae Diehl

Anna Mae Diehl

Florence McAlister Distinguished Professor of Medicine


Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.


Florence McAlister Distinguished Professor of Medicine in the School of Medicine

2005 School of Medicine

Professor of Medicine in the School of Medicine

2004 School of Medicine

Affiliate of the Duke Regeneration Center in the School of Medicine

2021 School of Medicine

Member of the Duke Cancer Institute in the School of Medicine

2004 School of Medicine


M.D. 1978

1978 Georgetown University

Medical Resident, Medicine

1981 Johns Hopkins University

Fellow in Gastroenterology, Medicine

1984 Johns Hopkins University

Publications, Grants & Awards

Offices & Contact

Ste 1073, GSRB 1
Durham, NC
Duke Box 3256
Durham, NC