Ashley Moseman
Assistant Professor of Integrative Immunobiology
Overview
Our lab seeks to understand central nervous system (CNS) immunity, with a specific focus on antimicrobial protection at the olfactory barrier. Barrier immunity, particularly at mucosal surfaces, has received a great deal of interest within the immunological community. Unlike classical barrier surfaces in the gut, lower respiratory tract, and skin, the olfactory neuroepithelial barrier is unique in its dedication to neuronal function. Olfactory sensory neurons (OSNs) must contact the external environment to perform their chemosensory functions, but this provides a direct link between the outside world and the CNS. For these reasons, our lab seeks to define the mechanisms by which immunological surveillance and the immune response within the olfactory epithelium is tailored to support both barrier and neurosensory functions while warding off neurotropic pathogens.
We are also strong believers that visualizing cellular behavior in vivo can guide mechanistic discovery. To this end, we employ multiphoton intravital imaging to analyze in vivo CNS immune responses and determine how these responses are tailored to the CNS environment. Within the CNS, intravital imaging has allowed us to observe dynamic in vivo antigen engagement by T cell subsets during viral infection as well as innate immune responses to Naegleria fowleri infection.
Positions
Assistant Professor of Integrative Immunobiology in the School of Medicine
2018 School of Medicine
Assistant Professor of Cell Biology in the School of Medicine
2022 School of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences in the Institutes and Provost's Academic Units
2020 Institutes and Provost's Academic Units
Member of the Duke Cancer Institute in the School of Medicine
2018 School of Medicine
Education
Ph.D. 2011
2011 Harvard University
Publications, Grants & Awards
- Grants (12)
- Academics Articles (33)
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Amazing Aven's Quest for Amoeba Awareness
American Academy Otolaryngology Head/Neck Surgery
Clemson University
National Institutes of Health
National Institutes of Health
Infectious Diseases Society of America
Methods Mol Biol
Sci Transl Med
J Clin Invest
Nat Immunol
Science Immunology
Nat Immunol
The Journal of Immunology
Nature
Nanomedicine (Lond)
Journal of Virology
Offices & Contact
Durham, NC
27710