Bruce Sullenger
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery
Overview
The main focus of my translational research laboratory is to develop RNA based therapeutic agents for the potential treatment of a range of diseases. To this end, we have and will continue to take advantage of the fact that RNA is not just a passive carrier of genetic instructions inside of cells during the conversion of information from DNA to RNA to protein. Rather, RNA is an extremely versatile biological macromolecule. Certian RNAs can bind to specific protiens with high affinities, while others can for catalytic centers and perform enzymatic reactions. These facets of RNA coupled with the ease with which RNA can be manipulated in vitro make it a very powerful and unique therapeutic agent whose potential is largely untapped. Durring our endeavors, we plan to work closely with the members of the Molecular Therapeutics program as well as other faculty at the Duke University Medical Center to expedite the development and testing of these therapeutics.
The specific aims of my laboratory are:
1. To isolate and characterize RNA and DNA aptamers which block therapeutically relavent proteins such as those involved in cardiovascular diseases and immune modulation.
2. To develop RNA-based tumor targeting strategies for delivering siRNAs and miRNAs to tumor cells.
3. To reprogram cells using mRNA delivery.
4. To explore novel methods to control inflammation.
Positions
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery in the School of Medicine
2003 School of Medicine
Professor in Surgery in the School of Medicine
2001 School of Medicine
Director of the Duke Center for Translational Research in the School of Medicine
2004 School of Medicine
Professor of Pharmacology and Cancer Biology in the School of Medicine
2012 School of Medicine
Professor of Neurosurgery in the School of Medicine
2019 School of Medicine
Professor of Cell Biology in the School of Medicine
2022 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1994 School of Medicine
Education
Ph.D. 1990
1990 Cornell University
Publications, Grants & Awards
- Grants (64)
- Awards (2)
- Academics Articles (179)
- Book Sections (4)
- Conference Pages (45)
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
American Heart Association
University of California - Berkeley
Department of Defense
National Institutes of Health
National Institutes of Health
Johns Hopkins University
National Institutes of Health
National Institutes of Health
University of California - Davis
Children's Hospital of Philadelphia
Department of Defense
National Institutes of Health
National Institutes of Health
Department of Defense
Department of Defense
Gateway Bio, Inc.
National Institutes of Health
National Institutes of Health
National Institutes of Health
MD Anderson Cancer Center
National Institutes of Health
National Institutes of Health
University of North Carolina - Chapel Hill
National Institutes of Health
National Institutes of Health
Department of Defense
University of North Carolina - Chapel Hill
National Institutes of Health
Department of Defense
National Institutes of Health
PhRMA Foundation
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
EpiCypher, Inc.
National Academy of Inventors
American Association for the Advancement of Science
Cell Chem Biol
Star Protocols
Cancers
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Frontiers in Immunology
Critical Care Explorations
Pharmaceuticals (Basel, Switzerland)
Nucleic Acid Ther
Molecular Therapy. Nucleic Acids
Molecular Therapy : the Journal of the American Society of Gene Therapy
Nature Reviews Materials
Molecular Therapy. Nucleic Acids
Science Advances
Science Advances
Molecular Therapy : the Journal of the American Society of Gene Therapy
Molecular Therapy. Nucleic Acids
J Neurointerv Surg
Cell
Cell Chem Biol
Molecular Therapy : the Journal of the American Society of Gene Therapy
Journal of Visualized Experiments : Jove
Curr Opin Hematol
Nat Biotechnol
Proc Natl Acad Sci U S A
Molecular Therapy : the Journal of the American Society of Gene Therapy
J Thromb Haemost
Molecular Therapy : the Journal of the American Society of Gene Therapy
Pharmaceuticals (Basel, Switzerland)
Biomaterials
Annu Rev Pharmacol Toxicol
Biomacromolecules
Biochemical and Biophysical Research Communications
Proc Natl Acad Sci U S A
Nucleic Acid Ther
Nucleic Acid Ther
Nucleic Acid Ther
The Journal of Allergy and Clinical Immunology
Molecular Therapy. Nucleic Acids
Nucleic Acid Ther
Stem Cells Dev
Arterioscler Thromb Vasc Biol
Plast Reconstr Surg
Nucleic Acid Ther
J Thromb Haemost
Nucleic Acid Ther
Nucleic Acid Ther
Proc Natl Acad Sci U S A
Curr Pharm Biotechnol
Nanomedicine
Nucleic Acid Ther
J Thromb Haemost
The Journal of Biological Chemistry
Molecular Therapy : the Journal of the American Society of Gene Therapy
Expert Rev Clin Immunol
Advances in Experimental Medicine and Biology
Nucleic Acid Ther
Nucleic Acid Ther
Proc Natl Acad Sci U S A
Nucleic Acid Ther
Journal of Thrombosis and Thrombolysis
Oligonucleotides
J Cardiovasc Transl Res
J Drug Target
Current Cardiology Reports
Thromb Haemost
The Journal of Biological Chemistry
Nat Chem Biol
Drugs of the Future
Ann N Y Acad Sci
Oligonucleotides
Biological Chemistry
Drugs of the Future
Molecular Therapy : the Journal of the American Society of Gene Therapy
Chinese Journal of Cancer Biotherapy
Chemistry & Biology
Journal of Surgical Research
Hum Gene Ther
Molecular Therapy : the Journal of the American Society of Gene Therapy
Molecular Therapy : the Journal of the American Society of Gene Therapy
The Journal of Clinical Investigation
Angiogenesis
Hamostaseologie
Proceedings of the National Academy of Sciences of the United States of America
Biochemical and Biophysical Research Communications
Rna (New York, N.Y.)
Gene Therapy
Oligonucleotides
Molecular Therapy
Nature Biotechnology
Nucleic Acids Res
Biochemical and Biophysical Research Communications
Thrombosis and Haemostasis
Molecular Therapy
Trends in Cardiovascular Medicine
Annual Review of Medicine
The New England Journal of Medicine
Nature Biotechnology
Expert Opin Biol Ther
Molecular Therapy
Febs Letters
Rna (New York, N.Y.)
Rna (New York, N.Y.)
Proceedings of the National Academy of Sciences of the United States of America
Organ Selective Actions of Steroid Hormones
The Journal of Clinical Investigation
Molecular Therapy
Molecular Therapy
Advanced Drug Delivery Reviews
Thrombosis and Haemostasis
The Journal of Clinical Investigation
Molecular Therapy
Science (New York, N.Y.)
Proceedings of the National Academy of Sciences of the United States of America
Gene Therapy
Molecular and Cellular Biology
Gene Therapy
Science (New York, N.Y.)
Nature Biotechnology
Nature Biotechnology
Methods in Molecular Biology (Clifton, N.J.)
Nature Medicine
Cytokines and Molecular Therapy
The Journal of Experimental Medicine
Chemistry & Biology
Proceedings of the National Academy of Sciences of the United States of America
Protein Engineering
Applied Biochemistry and Biotechnology
Molecular and Cell Biology of Human Diseases Series
Advances in Pharmacology (San Diego, Calif.)
Science (New York, N.Y.)
Journal of Virology
Molecular and Cellular Biology
Cell
Proceedings of the National Academy of Sciences of the United States of America
RNA Therapeutics: The Evolving Landscape of RNA Therapeutics
Concepts in Gene Therapy
RNA Technologies in Cardiovascular Medicine and Research
The Aptamer Handbook: Functional Oligonucleotides and Their Applications
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Cancer Immunology Research
Cancer Research
Molecular Therapy
Annals of Surgical Oncology
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Journal of the American College of Surgeons
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Journal of Thrombosis and Haemostasis : Jth
Molecular Therapy
Molecular Therapy
Cancer Research
Blood
Molecular Therapy
Arteriosclerosis, Thrombosis, and Vascular Biology
Journal of Thrombosis and Haemostasis : Jth
Nucleic Acid Therapeutics
Journal of Thrombosis and Haemostasis : Jth
Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
Abstracts of Papers of the American Chemical Society
Molecular Therapy
Arteriosclerosis, Thrombosis, and Vascular Biology
Circulation
Thrombosis and Haemostasis
Journal of Cellular Biochemistry
Offices & Contact
Durham, NC
27710 DUMC 103035
Durham, NC
27710