Corinne Linardic

Associate Professor of Pediatrics
Corinne Linardic
Corinne Linardic

Overview

Pediatric Sarcomas: Sarcomas are among the most difficult-to-treat cancers in pediatric oncology, with metastatic forms having the highest mortality. We have established genetically defined human cell-based models and genetically engineered murine models for the pediatric skeletal muscle cancer known as rhabdomyosarcoma. Using these models, we can study the causative role of certain genetic changes (e.g. chromosomal translocations and oncogenic RAS) in rhabdomyosarcoma formation and treatment resistance. Specific goals of this research program include the identification of signaling pathways corrupted in rhabdomyosarcoma, with focus on the PAX3-FOXO1 mutation and its downstream effectors and oncogenic RAS, and identification of new therapeutic targets for treatment of this childhood cancer.

Positions

Associate Professor of Pediatrics in the School of Medicine

2012 School of Medicine

Associate Professor of Pharmacology and Cancer Biology in the School of Medicine

2012 School of Medicine

Associate Professor of Cell Biology in the School of Medicine

2022 School of Medicine

Member of the Duke Cancer Institute in the School of Medicine

1999 School of Medicine

Education

Ph.D. 1993

1993 Duke University

M.D. 1995

1995 Duke University

Board Certification Hematology and Oncology

American Board of Pediatrics

Residency, Pediatrics

1998 Children's Hospital of Philadelphia

Fellow, Pediatric Hematology-Oncology, Pediatrics

1999 Children's Hospital of Philadelphia

Fellow, Pediatric Hematology-Oncology, Pediatrics

2001 Duke University

Publications, Grants & Awards

DCI Centers, Cancer Types & Labs

Offices & Contact

Box 102382, DUMC
Durham, NC
27710
LSRC Bldg Rm B361f, Research Drive
Durham, NC
27710