Corinne Linardic
Associate Professor of PediatricsOverview
Pediatric Sarcomas: Sarcomas are among the most difficult-to-treat cancers in pediatric oncology, with metastatic forms having the highest mortality. We have established genetically defined human cell-based models and genetically engineered murine models for the pediatric skeletal muscle cancer known as rhabdomyosarcoma. Using these models, we can study the causative role of certain genetic changes (e.g. chromosomal translocations and oncogenic RAS) in rhabdomyosarcoma formation and treatment resistance. Specific goals of this research program include the identification of signaling pathways corrupted in rhabdomyosarcoma, with focus on the PAX3-FOXO1 mutation and its downstream effectors and oncogenic RAS, and identification of new therapeutic targets for treatment of this childhood cancer.
Positions
Associate Professor of Pediatrics in the School of Medicine
2012 School of Medicine
Associate Professor of Pharmacology and Cancer Biology in the School of Medicine
2012 School of Medicine
Associate Professor of Cell Biology in the School of Medicine
2022 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1999 School of Medicine
Education
Ph.D. 1993
1993 Duke University
M.D. 1995
1995 Duke University
Board Certification Hematology and Oncology
American Board of Pediatrics
Residency, Pediatrics
1998 Children's Hospital of Philadelphia
Fellow, Pediatric Hematology-Oncology, Pediatrics
1999 Children's Hospital of Philadelphia
Fellow, Pediatric Hematology-Oncology, Pediatrics
2001 Duke University
Publications, Grants & Awards
- Grants (42)
- Awards (1)
- Academics Articles (73)
- Conference Pages (12)
- Book Sections (1)
National Institutes of Health
National Institutes of Health
Department of Defense
National Institutes of Health
National Institutes of Health
American Society for Pharmacology and Experimental Therapeutics
Alex's Lemonade Stand
National Institutes of Health
Ryvu Therapeutics
National Institutes of Health
Massachusetts General Hospital
Kate Amato Foundation Inc.
Rally! Foundation
Alex's Lemonade Stand
Public Health Institute
Public Health Institute
Alex's Lemonade Stand
National Institutes of Health
Alex's Lemonade Stand
Public Health Institute
Public Health Institute
Alex's Lemonade Stand
V Foundation for Cancer Research
Alex's Lemonade Stand
National Institutes of Health
Children's Hospital of Philadelphia
Children's Hospital of Philadelphia
St. Baldrick's Foundation
V Foundation for Cancer Research
National Institutes of Health
National Institutes of Health
Alex's Lemonade Stand
St. Baldrick's Foundation
V Foundation for Cancer Research
St. Baldrick's Foundation
Alex's Lemonade Stand
St. Baldrick's Foundation
Alex's Lemonade Stand
National Cancer Institute
V Foundation for Cancer Research
National Institutes of Health
National Institutes of Health
Graduate students in Basic Biomedical Sciences and the Duke University School of Medicine
Cell Rep Med
Pediatr Blood Cancer
Clinical Cancer Research
Pediatr Blood Cancer
Journal of Clinical Oncology
Scientific Reports
Journal of Clinical Medicine
Genet Med
Cell Biol Int
Pediatr Blood Cancer
International Journal of Cancer
Transl Behav Med
Am J Med Genet A
Clinical Cancer Research
Frontiers in Oncology
Mol Cancer Res
Cell Reports
Curr Drug Targets
Clinical Cancer Research
Am J Med Genet A
Frontiers in Oncology
Cold Spring Harbor Perspectives in Medicine
J Clin Invest
Case Reports in Pediatrics
Cancer Cell
Cell Reports
Int J Cancer
Frontiers in Oncology
Clinical Cancer Research
Clinical Cancer Research
Int J Radiat Oncol Biol Phys
Cancer Res
Cancer Lett
Methods in Enzymology
Cancer Research
Pediatric Blood & Cancer
Cancer Research
Cancer Research
Molecular and Cellular Biology
Cancer Research
Molecular Cancer Therapeutics
Medical and Pediatric Oncology
Pediatric Research
American Journal of Hematology
Cell Growth & Differentiation : the Molecular Biology Journal of the American Association for Cancer Research
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Biochimica Et Biophysica Acta
Faseb Journal
Clinical Research
Science (New York, N.Y.)
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Clinical Research
The Journal of Biological Chemistry
Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences
Molecular Cancer Research : Mcr
Molecular Cancer Research : Mcr
Molecular Cancer Research : Mcr
Molecular Cancer Research : Mcr
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Pediatric Oncology
DCI Centers, Cancer Types & Labs
Offices & Contact
Durham, NC
27710 LSRC Bldg Rm B361f, Research Drive
Durham, NC
27710