David Pisetsky
Professor of Medicine
Overview
Studies in my laboratory concern the immunological properties of DNA as related to two main topics: 1) the induction of anti-DNA responses in systemic lupus erythematosus; and 2) the stimulation of innate immunity by bacterial DNA. These topics are closely linked since we have established novel disease models in which lupus-like illness can be induced in normal mice by bacterial DNA under conditions in which mammalian DNA is inactive. This model has been useful in elucidating mechanisms of DNA antigen drive in autoimmunity.
To pursue these studies, our laboratory conducts investigations in the following areas: 1) specificity of anti-DNA for epitopes on mammalian and bacterial DNA; 2) molecular analysis of murine monoclonal anti-DNA antibodies; 3) histopathological analyses of DNA-immunized mice; 4) in vitro analysis of proliferation, antibody production and cytokine expression in human and murine immune cells; and 5) analysis of DNA binding to cell surface molecules on B cells, T cells and macrophages. Results of these studies have allowed identification of at least two structural motifs that are immunoactive. We are also exploring the impact of chemical modifications of the DNA backbone.
In addition to work on the immunology of DNA, I am also involved in clinical trials related to new immunomodulatory agents in the treatment of rheumatoid arthritis as well as serological markers of disease activity.
The areas of research for which I am known nationally are anti-DNA antibodies, systemic lupus erythematosus and immunological properties of DNA. I have written textbook chapters and reviews on all these subjects.
Positions
Professor of Medicine in the School of Medicine
1990 School of Medicine
Professor of Integrative Immunobiology in the School of Medicine
1994 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1978 School of Medicine
Member of the Duke Human Vaccine Institute in the School of Medicine
2014 School of Medicine
Education
Ph.D. 1972
1972 Yeshiva University, Albert Einstein College of Medicine
M.D. 1973
1973 Yeshiva University, Albert Einstein College of Medicine
Intern, Medicine
1974 Yale University School of Medicine
Resident, Medicine
1974 Yale University School of Medicine
Publications, Grants & Awards
- Grants (45)
- Academics Articles (479)
- Book Sections (5)
- Conference Pages (9)
Department of Defense
National Institutes of Health
Rheumatology Research Foundation
National Institutes of Health
University of California - San Francisco
National Institutes of Health
National Institutes of Health
Department of Defense
Durham Veterans Affairs Medical Center
National Institutes of Health
Cure JM Foundation
National Institutes of Health
Lupus Research Institute
National Institutes of Health
Durham Veterans Affairs Medical Center
Durham Veterans Affairs Medical Center
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Veterans Administration Medical Center
Veterans Administration Medical Center
National Institutes of Health
Veterans Administration Medical Center
Veterans Administration Medical Center
National Institutes of Health
VAMC
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Nat Rev Nephrol
Arthritis Rheumatol
Ann Intern Med
Cell Death Differ
The Lancet Rheumatology
Ann Intern Med
Lupus Science & Medicine
Lupus Science & Medicine
International Journal of Molecular Sciences
Ann Rheum Dis
Rheumatology (Oxford)
Nat Rev Rheumatol
Clin Immunol
Ann Intern Med
International Journal of Molecular Sciences
Ann Rheum Dis
Rheum Dis Clin North Am
Nat Rev Rheumatol
Arthritis Care Res (Hoboken)
Frontiers in Immunology
The Journal of Allergy and Clinical Immunology
Biointerphases
Ann Rheum Dis
Nat Rev Rheumatol
Best Pract Res Clin Rheumatol
The Lancet Rheumatology
Ann Rheum Dis
Ann Rheum Dis
Semin Arthritis Rheum
Ann Rheum Dis
Clin Immunol
Ann Rheum Dis
Rheumatology (Oxford)
Autoimmun Rev
Arthritis Rheumatol
Arthritis Care Res (Hoboken)
Ann Rheum Dis
Arthritis Care Res (Hoboken)
Ann Rheum Dis
F1000research
Eur J Clin Invest
Rheumatology (Oxford)
Ann Rheum Dis
Arthritis Research & Therapy
Ann Rheum Dis
Ann Rheum Dis
Ann Rheum Dis
Molecular Therapy : the Journal of the American Society of Gene Therapy
Frontiers in Immunology
Journal of Extracellular Vesicles
Arthritis Research & Therapy
Nat Rev Rheumatol
Lupus Science & Medicine
Advances in Protein Chemistry and Structural Biology
Gene Regulation and Systems Biology
North Carolina Medical Journal
Clinical and Experimental Rheumatology
Scientific Reports
Ann Rheum Dis
Arthritis Research & Therapy
Ann Intern Med
Clin Endocrinol (Oxf)
Clinical Therapeutics
Clin Immunol
Nat Rev Rheumatol
Therapeutic Innovation & Regulatory Science
Arthritis Research & Therapy
Arthritis Care Res (Hoboken)
Arthritis & Rheumatology
Scand J Immunol
Clin Immunol
Innate Immun
Antioxid Redox Signal
Arthritis Research & Therapy
Arthritis Research & Therapy
Arthritis Research & Therapy
Psychiatry Research
Arthritis Research & Therapy
Scand J Immunol
Immunol Res
Arthritis Care Res (Hoboken)
Arthritis Research & Therapy
Arthritis Research & Therapy
Arthritis Research & Therapy
Rheumatology (Oxford)
Innate Immun
Arthritis Research & Therapy
Scand J Immunol
Clinical Pharmacology and Therapeutics
Arthritis Research & Therapy
Arthritis Rheum
Best Pract Res Clin Rheumatol
Semin Arthritis Rheum
Arthritis Research & Therapy
Arthritis Research & Therapy
Expert Rev Clin Immunol
Arthritis Research & Therapy
Antioxid Redox Signal
J Thorac Oncol
Clin Vaccine Immunol
Proc Natl Acad Sci U S A
Nat Rev Rheumatol
J Autoimmun
Arthritis Research & Therapy
Immunol Res
The Journal of Rheumatology
Arthritis Research & Therapy
Arthritis Research & Therapy
Swiss Medical Weekly
Am J Physiol Cell Physiol
Autoimmun Rev
Ann Intern Med
Nat Rev Rheumatol
J Leukoc Biol
Arthritis Care Res (Hoboken)
The Journal of Rheumatology
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology
Nat Rev Rheumatol
Scand J Immunol
Arthritis and Rheumatism
J Clin Invest
Exp Cell Res
Arthritis Research & Therapy
Arthritis Rheum
Ann Rheum Dis
Molecular Immunology
Nat Clin Pract Rheumatol
Biomarkers
Arthritis and Rheumatism
Journal of Leukocyte Biology
Modern Rheumatology
Arthritis Research & Therapy
Arthritis Research & Therapy
Arthritis and Rheumatism
Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association
Annals of the New York Academy of Sciences
Proceedings of the American Thoracic Society
Immunology and Cell Biology
The Journal of Immunology
Current Opinion in Rheumatology
Annals of the Rheumatic Diseases
Apoptosis : an International Journal on Programmed Cell Death
Cancer Research
Nature Clinical Practice. Rheumatology
Scandinavian Journal of Immunology
American Journal of Physiology. Cell Physiology
The Journal of Immunology
Scandinavian Journal of Immunology
Arthritis and Rheumatism
Rheumatology (Oxford, England)
Arthritis Research & Therapy
Methods in Molecular Medicine
Bulletin of the Nyu Hospital for Joint Diseases
Clinical Immunology (Orlando, Fla.)
Arthritis and Rheumatism
Journal of Leukocyte Biology
Osteoarthritis and Cartilage
Apoptosis : an International Journal on Programmed Cell Death
Clinical and Diagnostic Laboratory Immunology
Journal of Women'S Health (2002)
Journal of Leukocyte Biology
Proceedings of the National Academy of Sciences of the United States of America
Arthritis and Rheumatism
Osteoarthritis and Cartilage
Autoimmunity Reviews
Nature Immunology
Rheumatic Disease Clinics of North America
Arthritis and Rheumatism
Autoimmunity
Clinical Orthopaedics and Related Research®
Biochemical and Biophysical Research Communications
The American Journal of Pathology
Cellular Immunology
Rheumatic Disease Clinics of North America
The Pharos of Alpha Omega Alpha Honor Medical Society. Alpha Omega Alpha
Scandinavian Journal of Immunology
Bulletin on the Rheumatic Diseases
Clinical Immunology (Orlando, Fla.)
Blood
Current Rheumatology Reports
Journal of Applied Physiology (Bethesda, Md. : 1985)
Arthritis and Rheumatism
Scandinavian Journal of Immunology
Arthritis and Rheumatism
Current Opinion in Molecular Therapeutics
Arthritis and Rheumatism
Arthritis and Rheumatism
Arthritis and Rheumatism
Arthritis and Rheumatism
Clinical Immunology (Orlando, Fla.)
Journal of Leukocyte Biology
Osteoarthritis and Cartilage
Ann Intern Med
Arthritis and Rheumatism
Journal of Leukocyte Biology
Arthritis and Rheumatism
Lancet (London, England)
Scandinavian Journal of Immunology
Infection and Immunity
The Israel Medical Association Journal : Imaj
Infection and Immunity
Arthritis and Rheumatism
Clinical Immunology (Orlando, Fla.)
Biochemical and Biophysical Research Communications
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Osteoarthritis and Cartilage
Arthritis and Rheumatism
Arthritis and Rheumatism
American Journal of Human Genetics
Arthritis and Rheumatism
Arthritis and Rheumatism
Clinical Immunology (Orlando, Fla.)
Current Opinion in Rheumatology
The Journal of Immunology
Cellular Immunology
The New England Journal of Medicine
Current Topics in Microbiology and Immunology
Springer Seminars in Immunopathology
Methods in Molecular Medicine
Immunologic Research
Springer Seminars in Immunopathology
Biochemical Pharmacology
Journal of Interferon & Cytokine Research
The Journal of Rheumatology
The Journal of Immunology
Clinical and Experimental Immunology
Arthritis and Rheumatism
Rheumatic Disease Clinics of North America
Annals of Internal Medicine
Rheumatic Disease Clinics of North America
Immunologic Research
Molecular Immunology
Health News (Waltham, Mass.)
Immunopharmacology
The Journal of Immunology
Human Gene Therapy
Annals of Internal Medicine
The Journal of Rheumatology
Clinical and Diagnostic Laboratory Immunology
Clinical Immunology and Immunopathology
Environmental Toxicology and Pharmacology
Journal of General Internal Medicine
The Journal of Experimental Medicine
Nature Medicine
Clinical and Experimental Immunology
The Journal of Immunology
Proceedings of the Association of American Physicians
Annals of Internal Medicine
The Medical Clinics of North America
Methods (San Diego, Calif.)
The Journal of Immunology
The Journal of Rheumatology
The Journal of Clinical Investigation
The Journal of Experimental Medicine
European Journal of Immunology
Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association
Annals of Internal Medicine
The Journal of Experimental Medicine
The Journal of Rheumatology
Annals of Internal Medicine
Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association
The Journal of Immunology
Cellular Immunology
The Journal of Medical Humanities
North Carolina Medical Journal
Annals of the New York Academy of Sciences
Clinical Immunology and Immunopathology
Clinical Immunology and Immunopathology
Clinical Immunology and Immunopathology
The Journal of Clinical Investigation
Immunopharmacology
Antisense Research and Development
The Journal of Immunology
Clinical Immunology and Immunopathology
International Archives of Allergy and Immunology
Clinical Immunology and Immunopathology
European Journal of Immunology
The Journal of Experimental Medicine
Immunology and Allergy Clinics of North America
Arthritis and Rheumatism
Human Immunology
The Journal of Rheumatology
Molecular Biology Reports
Clinical Immunology and Immunopathology
Current Opinion in Rheumatology
The Journal of Immunology
Lupus
Molecular Biology Reports
Cellular Immunology
The Journal of Immunology
The Journal of Pharmacology and Experimental Therapeutics
Journal of Autoimmunity
The Journal of Experimental Medicine
Current Opinion in Rheumatology
Clinical Immunology and Immunopathology
Molecular Immunology
Rheumatic Disease Clinics of North America
Kidney International
Cellular Immunology
Clinical Immunology and Immunopathology
Concepts in Immunopathology
International Archives of Allergy and Immunology
Clinical and Experimental Rheumatology
Current Opinion in Immunology
Current Opinion in Rheumatology
The Journal of Immunology
Journal of Investigative Dermatology
Journal of Autoimmunity
Prostaglandins
Human Immunology
Clinical Immunology and Immunopathology
The Journal of Rheumatology
The Journal of Immunology
The Journal of Rheumatology
Kidney International
Clinical Immunology and Immunopathology
Clinical Immunology and Immunopathology
Clinical and Experimental Immunology
European Journal of Immunology
The Journal of Immunology
Clinical Immunology and Immunopathology
The Journal of Clinical Investigation
Arthritis and Rheumatism
Clinical Immunology and Immunopathology
The Journal of Clinical Investigation
The Journal of Experimental Medicine
The Journal of Clinical Investigation
The Journal of Immunology
Clinical Immunology and Immunopathology
The Journal of Rheumatology
Journal of Autoimmunity
Clinical Immunology and Immunopathology
The Journal of Rheumatology
The Journal of Immunology
Clinical and Experimental Rheumatology
The Journal of Immunology
The American Journal of Medicine
Immunology
The American Journal of Medicine
The Journal of Rheumatology
Arthritis and Rheumatism
The Journal of Immunology
Clinical and Experimental Immunology
In Vivo (Athens, Greece)
Rheumatic Disease Clinics of North America
Proceedings of the National Academy of Sciences of the United States of America
Journal of Immunological Methods
Clinical Immunology and Immunopathology
Cellular Immunology
Molecular Immunology
The Journal of Immunology
The Journal of Immunology
Arthritis and Rheumatism
Research Communications in Chemical Pathology and Pharmacology
Clinical Immunology and Immunopathology
Clinical and Experimental Immunology
The Medical Clinics of North America
The Journal of Immunology
Cellular Immunology
Clinical Immunology and Immunopathology
Cellular Immunology
Clinical Immunology and Immunopathology
Clinical Immunology and Immunopathology
Clinical Immunology and Immunopathology
Clinical Immunology and Immunopathology
Clinical and Experimental Immunology
Journal of Immunological Methods
The Journal of Immunology
Clinical and Experimental Immunology
Arthritis and Rheumatism
Clinical Immunology and Immunopathology
Clinical Immunology and Immunopathology
Cellular Immunology
Cellular Immunology
Clinical Immunology Reviews
Cellular Immunology
Molecular Immunology
Clinical Immunology and Immunopathology
The Journal of Immunology
Cellular Immunology
The Journal of Immunology
Molecular Immunology
Archives of Pathology & Laboratory Medicine
The Journal of Immunology
The Journal of Rheumatology
The Journal of Immunology
The Journal of Immunology
Journal of Immunological Methods
The Journal of Experimental Medicine
The Journal of Immunology
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Springer Seminars in Immunopathology
Advances in Experimental Medicine and Biology
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Cold Spring Harbor Symposia on Quantitative Biology
Journal of Molecular Biology
Biochimica Et Biophysica Acta
Biochimica Et Biophysica Acta
A Clinician's Pearls and Myths in Rheumatology: Second Edition
Diagnoses Without Names: Challenges for Medical Care, Research, and Policy
Dubois' Lupus Erythematosus and Related Syndromes
Lupus Erythematosus: Clinical Evaluation and Treatment
Medicine Science and Dreams: The Making of Physician-Scientists
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Arthritis & Rheumatology
Arthritis and Rheumatism
Arthritis and Rheumatism
Arthritis Research & Therapy
Arthritis and Rheumatism
Arthritis and Rheumatism
Arthritis and Rheumatism
Offices & Contact
Durham, NC
27705 VA Med Ctr, 508 Fulton St
Durham, NC
27705