Donald McDonnell
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine
Overview
The research in our group is focused on the development and application of mechanism based approaches to identify novel therapeutics for use in the treatment and prevention of hormonally responsive cancers. Specifically we are interested in the pharmaceutical exploitation of the estrogen and androgen receptors as therapeutic targets in breast and prostate cancers and in defining how these receptors influence the pathogenesis of these diseases. These efforts have led to the discovery of several drugs that are currently being evaluated in the clinic as cancer therapeutics, and to the identification of potential biomarkers and predictors of response that can help to target the use of these new drugs. Most recently we have explored approaches to treat triple negative breast cancer and have identified an important pathway that links obesity/dyslipidemia and cancer risk.
Positions
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine in the School of Medicine
2002 School of Medicine
Professor of Pharmacology and Cancer Biology in the School of Medicine
2000 School of Medicine
Professor in Medicine in the School of Medicine
2002 School of Medicine
Professor of Cell Biology in the School of Medicine
2022 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1994 School of Medicine
Education
Ph.D. 1988
1988 Baylor College of Medicine
Publications, Grants & Awards
- Grants (85)
- Awards (22)
- Academics Articles (321)
- Conference Pages (30)
- Book Sections (2)
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Department of Defense
National Institutes of Health
National Institutes of Health
National Institutes of Health
American Society for Pharmacology and Experimental Therapeutics
National Institutes of Health
National Institutes of Health
National Institutes of Health
Department of Defense
National Institutes of Health
National Institutes of Health
National Institutes of Health
Susan G. Komen Breast Cancer Foundation
National Institutes of Health
National Institutes of Health
Department of Defense
Prostate Cancer Foundation
National Institutes of Health
American Cancer Society, Inc.
National Institutes of Health
Celgene Corporation
Ribometrix LLC
National Institutes of Health
Department of Defense
National Institutes of Health
The Melanoma Research Foundation
National Institutes of Health
Department of Defense
National Institutes of Health
National Institutes of Health
University of North Carolina - Chapel Hill
American Association of Obstetricians and Gynecologists Foundation
National Institutes of Health
Department of Defense
National Institutes of Health
National Institutes of Health
American Society for Pharmacology and Experimental Therapeutics
Department of Defense
Department of Defense
Department of Defense
American Cancer Society, Inc.
National Institute of Environmental Health Sciences
National Institutes of Health
National Institutes of Health
Susan G. Komen Breast Cancer Foundation
Susan G. Komen Breast Cancer Foundation
National Institutes of Health
North Carolina Biotechnology Center
Department of Defense
Cell Design Labs, Inc
National Institutes of Health
Susan G. Komen Breast Cancer Foundation
National Institutes of Health
Innocrin Pharmaceutical, Inc.
National Institutes of Health
National Institutes of Health
Vanderbilt University
United States Army Medical Research and Materiel Command
G1 Therapeutics Inc.
National Institutes of Health
National Cancer Institute
American Cancer Society, Inc.
Innocrin Pharmaceutical, Inc.
Arvinas Inc.
National Institutes of Health
National Institutes of Health
Viamet Pharmaceuticals
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Science Foundation Ireland (SFI)
Endocrine Society
National Academy of Inventors
Duke Medical Alumni Association
National Academy of Medicine
Baylor College of Medicine
The Endocrine Society
American Association for the Advancement of Science, The
Royal College of Physicians, Ireland
National University of Ireland, Galway
Pharmacia-ASPET
Biolink USA-Ireland
National Institutes of Health
Endocrine Society
Duke University School of Medicine
NAMS / Eli LIlly and Company
Endocrine Society
Aer Lingus
European Union
Journal of Medicinal Chemistry
Helvetica Chimica Acta
Nature Communications
Proc Natl Acad Sci U S A
Cancer Immunol Res
Trends Endocrinol Metab
Clinical Cancer Research
Nature Communications
Cancers
Acs Medicinal Chemistry Letters
Essays Biochem
J Clin Invest
Journal of Medicinal Chemistry
Nature Communications
Journal of Clinical Oncology
Mol Cancer Ther
Breast Cancer Res Treat
Breast Cancer Res Treat
Scientific Data
Nature Communications
Prostate
J Bone Miner Res
Nature Communications
Journal of Medicinal Chemistry
Prostate
Cancer Cell
Communications Biology
Nature Communications
Endocrinology
Oncogene
Oncogene
Endocr Relat Cancer
J Clin Invest
Journal of Medicinal Chemistry
The Journal of Biological Chemistry
Sci Transl Med
Journal of Women'S Health (2002)
Cell Reports
British Journal of Pharmacology
Clinical Cancer Research
Endocr Relat Cancer
Mol Endocrinol
Angew Chem Int Ed Engl
The Journal of Biological Chemistry
Journal of Medicinal Chemistry
Sci Signal
Mol Cancer Res
Climacteric
Trends Endocrinol Metab
Horm Cancer
Mol Endocrinol
Endocrine Reviews
Proc Natl Acad Sci U S A
Bioorg Med Chem
Proc Natl Acad Sci U S A
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Cancer Research
J Clin Invest
Clinical Cancer Research
Bioorg Med Chem Lett
Advances in Experimental Medicine and Biology
Proc Natl Acad Sci U S A
Cancer Cell
The Journal of Biological Chemistry
Mol Endocrinol
Mol Endocrinol
Curr Opin Pharmacol
The Journal of Biological Chemistry
Endocrinology
Protein Expr Purif
Molecular and Cellular Biology
Stem Cells
Mol Endocrinol
Mol Endocrinol
Proc Natl Acad Sci U S A
Biology of Reproduction
Chemistry & Biology
Molecular and Cellular Endocrinology
J Steroid Biochem Mol Biol
Molecular Endocrinology (Baltimore, Md.)
Molecular Endocrinology (Baltimore, Md.)
Biology of Reproduction
Trends in Pharmacological Sciences
Molecular Cancer Therapeutics
Nature Medicine
Molecular Endocrinology (Baltimore, Md.)
Journal of Medicinal Chemistry
Cancer Research
Molecular Endocrinology (Baltimore, Md.)
Molecular Endocrinology (Baltimore, Md.)
Archives of Biochemistry and Biophysics
The Journal of Biological Chemistry
Molecular Endocrinology (Baltimore, Md.)
The Journal of Biological Chemistry
Molecular Cell
Pharmacological Reviews
Endocrine Related Cancer
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology
Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
Molecular Endocrinology (Baltimore, Md.)
Proceedings of the National Academy of Sciences of the United States of America
Molecular Endocrinology (Baltimore, Md.)
Drugs of the Future
Bioorganic & Medicinal Chemistry Letters
Journal of Molecular Biology
Molecular Interventions
Molecular Endocrinology (Baltimore, Md.)
Journal of Medicinal Chemistry
Trends in Pharmacological Sciences
Nature Structural & Molecular Biology
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Nuclear Receptor Signaling
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Biochemical and Biophysical Research Communications
Molecular Cell
European Journal of Cancer Supplements
Journal of Andrology
Cancer Research
Endocrinology
Journal of Cellular Biochemistry
Pure and Applied Chemistry
Journal of the British Menopause Society
Methods in Enzymology
Journal of Bone and Mineral Research
Environmental Health Perspectives
Endocrinology
Molecular Endocrinology (Baltimore, Md.)
Endocrinology
The American Journal of Cardiology
Molecular Endocrinology (Baltimore, Md.)
Molecular and Cellular Biology
Molecular Endocrinology (Baltimore, Md.)
Molecular Endocrinology (Baltimore, Md.)
Molecular Endocrinology (Baltimore, Md.)
Molecular Endocrinology (Baltimore, Md.)
Recent Progress in Hormone Research
Cancer Research
Annals of the New York Academy of Sciences
Endocrinology
The Journal of Biological Chemistry
Journal of Bone and Mineral Research
The Journal of Biological Chemistry
Cancer Research
Organ Selective Actions of Steroid Hormones
Reproduction, Fertility, and Development
Molecular Endocrinology (Baltimore, Md.)
Molecular Endocrinology (Baltimore, Md.)
The Journal of Steroid Biochemistry and Molecular Biology
Molecular Pharmacology
The Journal of Biological Chemistry
Molecular and Cellular Biology
Journal of the Society for Gynecologic Investigation
Molecular and Cellular Biology
Trends Endocrinol Metab
Molecular and Cellular Biology
Science (New York, N.Y.)
Molecular Endocrinology (Baltimore, Md.)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Recent Progress in Hormone Research
International Journal of Fertility and Menopausal Studies
Molecular and Cellular Endocrinology
Toxicology and Applied Pharmacology
The Journal of Biological Chemistry
Molecular and Cellular Biology
Biochemical Society Transactions
The Journal of Biological Chemistry
Toxicology and Applied Pharmacology
Environmental Health Perspectives
Molecular Endocrinology (Baltimore, Md.)
Toxicology and Applied Pharmacology
Science (New York, N.Y.)
Molecular Endocrinology (Baltimore, Md.)
Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa
Molecular Endocrinology (Baltimore, Md.)
Proceedings of the National Academy of Sciences of the United States of America
Molecular and Cellular Biology
Vitamins and Hormones
Electrical Contacts, Proceedings of the Annual Holm Conference on Electrical Contacts
The Journal of Biological Chemistry
Annals of the New York Academy of Sciences
Molecular Endocrinology (Baltimore, Md.)
The Journal of Steroid Biochemistry and Molecular Biology
Current Opinion in Biotechnology
Trends in Endocrinology and Metabolism: Tem
Electrical Contacts, Proceedings of the Annual Holm Conference on Electrical Contacts
The Journal of Clinical Investigation
Molecular and Cellular Biology
The Journal of Steroid Biochemistry and Molecular Biology
Seminars in Cancer Biology
Biochemistry
Molecular Endocrinology (Baltimore, Md.)
The Journal of Steroid Biochemistry and Molecular Biology
The Journal of Biological Chemistry
The Journal of Steroid Biochemistry and Molecular Biology
Molecular Endocrinology (Baltimore, Md.)
Electrical Contacts, Proceedings of the Annual Holm Conference on Electrical Contacts
Journal of Clinical Pharmacology
Bio/Technology
Molecular Endocrinology (Baltimore, Md.)
Biochemical Medicine and Metabolic Biology
Molecular Endocrinology (Baltimore, Md.)
Molecular Carcinogenesis
Proceedings of the National Academy of Sciences of the United States of America
The Journal of Biological Chemistry
Molecular Endocrinology (Baltimore, Md.)
Molecular Endocrinology (Baltimore, Md.)
Biochemistry
Cancer Research
Gene Expression
The Journal of Biological Chemistry
Molecular and Cellular Biology
The Journal of Steroid Biochemistry and Molecular Biology
Proceedings of the National Academy of Sciences of the United States of America
Cancer Research
The Journal of Biological Chemistry
Proceedings of the National Academy of Sciences of the United States of America
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Molecular and Cellular Biology
Molecular Endocrinology (Baltimore, Md.)
Advances in Experimental Medicine and Biology
Proceedings of the National Academy of Sciences of the United States of America
Recent Progress in Hormone Research
Journal of Steroid Biochemistry
Science (New York, N.Y.)
Molecular Endocrinology (Baltimore, Md.)
Nucleic Acids Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Immunology Research
Cancer Immunology Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Annals of Oncology
Cancer Research
European Journal of Cancer
Cancer Research
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cancer Research
Cancer Research
Abstracts of Papers of the American Chemical Society
Endocrine Reviews
Investigative Ophthalmology & Visual Science
Investigative Ophthalmology & Visual Science
Menopause (New York, N.Y.)
Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Breast Cancer Research and Treatment
Abstracts of Papers of the American Chemical Society
Biology of Reproduction
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment
Journal of the Society for Gynecologic Investigation
Organ Selective Actions of Steroid Hormones
NR Coregulators and Human Diseases
Treatment of the Postmenopausal Woman: Basic and Clinical Aspects, Third Edition
DCI Centers, Cancer Types & Labs
Offices & Contact
Durham, NC
27708 Duke Box 3813
Durham, NC
27710