Ganesan Vaidyanathan
Professor Emeritus in RadiologyOverview
Dr. Vaidyanathan is a professor in the Department of Radiology. He is a member of the Nuclear Medicine track of the Medical Physics Graduate Program. His research involves development of radiopharmaceuticals especially for oncologic applications. Some of the projects he is involved in are given below.
I. New methods of radiohalogenating antibodies and its variants
a) Development of newer residualizing agents for the radiohalogenation of internalizing monoclonal antibodies.
b) Development of fluorine-18 labeled residualizing agents for labeling nanobodies.
c) Pre-targeting approach via bioorthogonal chemistry for in vivo labeling of antibodies and nanobodies with 18F and 211At.
d) Methods to label antibodies pre-conjugated with a prosthetic group of the tin precursor of residualizing agents.
e) Multimodal prosthetic groups for labeling antibodies and peptides with multiple radioisotopes.
II. MIBG Analogs for PET imaging
Radioiodinated MIBG is used in the diagnosis of the pathophysiology of the heart as well as neuroendocrine tumors such as neuroblastoma (NB). Design and development of newer fluorine-18 labeled MIBG analogues useful in the PET imaging of NB as well as that of myocardial diseases.
III. Noninvasive Imaging of Alkylguanine-DNA alkyltransferase (AGT)
AGT is a DNA repair protein and is primarily responsible for drug resistance in alkylator chemotherapy. An inverse correlation has been established between the tumor AGT content and the therapeutic outcome. The amount of AGT varies from tumor to tumor and within a group of patients of similar cancer. Thus, it is important to quantify tumor AGT of individual patients before administering alkylator chemotherapy. Our goal is to develop radiolabeled agents with which AGT can be quantified in a noninvasive manner by PET or SPECT imaging.
IV. PSMA targeting for prostate cancer therapy
Development of At-211 labeled urea-based inhibitor of Prostate-specific membrane antigen.
Positions
Professor Emeritus in Radiology in the School of Medicine
2022 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1989 School of Medicine
Education
Ph.D. 1987
1987 University of Kentucky
Teaching Assistant, Chemistry Dept
1987 University of Kentucky
Postdoctoral, College Of Pharmacy
1989 University of Kentucky
Publications, Grants & Awards
- Grants (35)
- Academics Articles (183)
- Conference Pages (38)
- Book Sections (1)
National Institutes of Health
Zentera Alpha, Inc
National Institutes of Health
National Institutes of Health
Cereius Inc.
Department of Defense
Memorial Sloan-Kettering Cancer Center
National Institutes of Health
Children's Hospital of Philadelphia
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Department of Energy
National Institutes of Health
National Institutes of Health
Department of Energy
National Institutes of Health
Department of Energy
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Department of Energy
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
National Institutes of Health
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Medicinal Chemistry
Clinical Cancer Research
Scientific Reports
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Neuro Oncology Advances
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Nucl Med Biol
Int J Nanomedicine
Int J Nanomedicine
Cancer Biother Radiopharm
Molecules (Basel, Switzerland)
Nanotechnology
Molecules (Basel, Switzerland)
Nucl Med Biol
Molecular Imaging and Biology
Curr Radiopharm
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Current Radiopharmaceuticals
Nucl Med Biol
Theranostics
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Eur J Nucl Med Mol Imaging
Chemistry & Biology
Journal of Labelled Compounds & Radiopharmaceuticals
Journal of Labelled Compounds & Radiopharmaceuticals
Ieee Nuclear Science Symposium Conference Record
Ejnmmi Research
Curr Radiopharm
Journal of Labelled Compounds & Radiopharmaceuticals
Current Radiopharmaceuticals
Nucl Med Biol
Nucl Med Biol
Anticancer Res
Curr Radiopharm
Nuclear Medicine and Biology
Curr Radiopharm
Journal of Labelled Compounds & Radiopharmaceuticals
The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (Aimn) [And] the International Association of Radiopharmacology (Iar), [And] Section of the Society Of..
Journal of Chemical Information and Modeling
International Journal of Radiation Oncology, Biology, Physics
Curr Radiopharm
Journal of Chemical Information and Modeling
Nuclear Medicine and Biology
Bioorganic & Medicinal Chemistry
Protein Journal
Journal of Labelled Compounds & Radiopharmaceuticals
Bioconjugate Chemistry
Nuclear Medicine and Biology
Nuclear Medicine and Biology
Bioconjugate Chemistry
Bioorganic & Medicinal Chemistry
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Transactions of the American Nuclear Society
European Journal of Nuclear Medicine and Molecular Imaging
Nuclear Medicine and Biology
Journal of Pharmaceutical and Biomedical Analysis
Nuclear Medicine Communications
The Journal of Gene Medicine
Annals of the New York Academy of Sciences
Bioorganic & Medicinal Chemistry
Bioconjugate Chemistry
Current Pharmaceutical Design
Journal of Pharmaceutical and Biomedical Analysis
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Nuclear Medicine and Biology
Bioconjugate Chemistry
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Nuclear Medicine and Biology
Methods in Enzymology
Bioconjugate Chemistry
Bioconjugate Chemistry
Bioconjugate Chemistry
Current Pharmaceutical Design
Current Pharmaceutical Design
Nuclear Medicine and Biology
Journal of Inorganic Biochemistry
Bioconjugate Chemistry
Abstracts of Papers of the American Chemical Society
Journal of Labelled Compounds & Radiopharmaceuticals
Radiation Research
Nuclear Medicine and Biology
British Journal of Cancer
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Abstracts of Papers of the American Chemical Society
Nuclear Medicine and Biology
Bioconjugate Chemistry
Bioconjugate Chemistry
The Journal of Organic Chemistry
International Journal of Radiation Biology
British Journal of Cancer
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Nuclear Medicine and Biology
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
British Journal of Cancer
Bioconjugate Chemistry
British Journal of Cancer
Physics in Medicine and Biology
Nuclear Medicine and Biology
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
British Journal of Cancer
Cancer Research
Bioconjugate Chemistry
Cancer Research
Nuclear Medicine and Biology
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Nuclear Medicine and Biology
Nuclear Medicine and Biology
Nuclear Medicine and Biology
European Journal of Cancer
Journal of Neuro Oncology
Cancer Research
Journal of Medicinal Chemistry
Nuclear Medicine and Biology
International Journal of Cancer
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Nuclear Medicine Communications
Proceedings of the National Academy of Sciences of the United States of America
Journal of Labelled Compounds & Radiopharmaceuticals
Nuclear Medicine and Biology
Bioconjugate Chemistry
Progress in Clinical and Biological Research
Journal of Labelled Compounds and Radiopharmaceuticals
Journal of Medicinal Chemistry
Circulation
Physics in Medicine and Biology
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Bioconjugate Chemistry
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
Bioconjugate Chemistry
Bioconjugate Chemistry
Journal of Labelled Compounds & Radiopharmaceuticals
Abstracts of Papers of the American Chemical Society
Bioconjugate Chemistry
Bioconjugate Chemistry
The Journal of Organic Chemistry
The Journal of Organic Chemistry
Nuclear Medicine and Biology
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Labelled Compounds & Radiopharmaceuticals
Journal of Labelled Compounds & Radiopharmaceuticals
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
European Journal of Nuclear Medicine and Molecular Imaging
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
European Journal of Nuclear Medicine and Molecular Imaging
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Febs Journal
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Radiotherapy and Oncology
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Neuro Oncology
European Journal of Nuclear Medicine and Molecular Imaging
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging
Cancer Research
Abstracts of Papers of the American Chemical Society
Neuro Oncology
Neuro Oncology
Abstracts of Papers of the American Chemical Society
PROCEEDINGS OF THE XVI INTERNATIONAL CANCER CONGRESS - FREE PAPERS AND POSTERS, TOMES 1-4
Journal of Labelled Compounds & Radiopharmaceuticals
Radiopharmaceutical Chemistry
Offices & Contact
Durham, NC
27710 Box 3808 Med Ctr, Radiology
Durham, NC
27710